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Protein

Protein MMS22-like

Gene

Mms22l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MMS22-like
Alternative name(s):
Methyl methanesulfonate-sensitivity protein 22-like
Gene namesi
Name:Mms22l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2684980 Mms22l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004037721 – 1238Protein MMS22-likeAdd BLAST1238

Proteomic databases

EPDiB1AUR6
MaxQBiB1AUR6
PaxDbiB1AUR6
PeptideAtlasiB1AUR6
PRIDEiB1AUR6

PTM databases

iPTMnetiB1AUR6
PhosphoSitePlusiB1AUR6

Expressioni

Gene expression databases

BgeeiENSMUSG00000045751 Expressed in 167 organ(s), highest expression level in embryonic stem cell
ExpressionAtlasiB1AUR6 baseline and differential
GenevisibleiB1AUR6 MM

Interactioni

Subunit structurei

Component of the MMS22L-TONSL complex, a complex at least composed of MMS22L and TONSL/NFKBIL2.By similarity

Protein-protein interaction databases

BioGridi229314, 1 interactor
STRINGi10090.ENSMUSP00000103857

Family & Domainsi

Sequence similaritiesi

Belongs to the MMS22 family. MMS22L subfamily.Curated

Phylogenomic databases

eggNOGiENOG410IEVD Eukaryota
ENOG410ZSY3 LUCA
GeneTreeiENSGT00390000011769
HOGENOMiHOG000049190
HOVERGENiHBG058755
InParanoidiB1AUR6
OMAiYQFDRHG
OrthoDBiEOG091G04DE
PhylomeDBiB1AUR6
TreeFamiTF353832

Family and domain databases

InterProiView protein in InterPro
IPR029424 MMS22L_C
IPR029425 MMS22L_N
PfamiView protein in Pfam
PF14911 MMS22L_C, 1 hit
PF14910 MMS22L_N, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: B1AUR6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDGCSAASTF LTDSLELELG TEWCKPPCFS CAFDNREGKF SGESYLASGA
60 70 80 90 100
LKRLILNLDP LPTNFEEDTV ELFGFQWVTE TALVYSCREL FHLFRQQIFN
110 120 130 140 150
LESLVQVSCD FGKIATLHAK ADSIRQQCVV FLHYIKVFIF RCLKVQEAES
160 170 180 190 200
HSRPAHPYEA LEAQLPSMLV DELRGLLLYI GHLAALPSVT VGAFVNQNQM
210 220 230 240 250
KLFPPSWHLL HLYLDTHWLV LEILHILGEK LKQVVYGRQF IGQAGDNLTN
260 270 280 290 300
VSLFEEHCEH LFCDLICLSL NRFDKVMPSE ALLISHCPCS CVKELWVLLI
310 320 330 340 350
HLLDHRRKWS VADSFWNWLN KLLRTLFEKS SDQRRSSVSL TQAKDPLGFS
360 370 380 390 400
WWISVHVASL YQIDRHGVSD KMKQMESNWS FIEELLKRSV TVQDSILEEQ
410 420 430 440 450
LRMHLHCCLT LCDFWEPNIS VVTILWEYYS KNLNSSFSIS WLPLKGLTNI
460 470 480 490 500
IKSPLSMLTL VRNCCSDKQD PDLYKSSSSY IIFLCILAKV VKKAMRTSGP
510 520 530 540 550
HPWKQVKGRI YSKFHQKRME ELTEVGLQNF FSLFLLLAAV AEIEDVASHV
560 570 580 590 600
LDLLRFLRPA SMSSHGALVW KGQMAFLLMY AQKNLDIGVW AEKLSCEFQE
610 620 630 640 650
KAKEFLVSKN DEMVQRHALW TLLCIYIDGV QEVFETSSCL YPSHEHLLND
660 670 680 690 700
GFSMLLPACR ESELRTVLNF LQAVLARIRS VHQQLCQELQ RENVDLTVQS
710 720 730 740 750
SLSAKERPLA AVAGALWRHF FSFLKSQRMT QVVPLSQLAD AAADFTLLAV
760 770 780 790 800
DMPNTAPPDL QPQPVISIIQ LFGWDDIIWP QVVARYLSHL LQNSTVYEAL
810 820 830 840 850
SQSSCVSSQS LTIRSWVRCV LQMHIKHLSD PDLLIDVNPE QAVEKEYMEQ
860 870 880 890 900
LAEMTRLLFT LSEVKSVFSK AQIEQLPSPD DPKQALIQFL EAVGVTYRTL
910 920 930 940 950
QTFSDKSAMV TKSLEYLGEV LKYIKPYLGK KVSSAGLQLT YGIMGILVKS
960 970 980 990 1000
WAHIFATSKA QKLLFRIIDC LLLPHTVLQQ DKELPGPMLT AIQKTLPLYL
1010 1020 1030 1040 1050
QGICIVCCQS QNPNAYLNQL LRNVIEQYIG RFLPTSPCVS DLGQHPVLLA
1060 1070 1080 1090 1100
LRNPASVPSM TPLRKHTVHA IRKSYLEFKG SSPPPRLASV LAFVLQLFKD
1110 1120 1130 1140 1150
TEMGACDLEL LLPGILKCLV LVNEPQVKKL ATENLQCMVQ TCQVGSEGGP
1160 1170 1180 1190 1200
ATQLTSLFRQ FIQDYGMQYS YQVYSILETV ATLNQHVVIQ LIPTLTQSLK
1210 1220 1230
DSELKWGLGR NIAQREAYSR LLSGLGQVGQ GEKQRLEK
Length:1,238
Mass (Da):140,582
Last modified:April 8, 2008 - v1
Checksum:i9C2733D598CF2F2D
GO
Isoform 2 (identifier: B1AUR6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-276: Missing.
     793-793: N → NS

Note: No experimental confirmation available.
Show »
Length:963
Mass (Da):109,242
Checksum:i91CE2C35CABA608A
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G8JL47G8JL47_MOUSE
Protein MMS22-like
Mms22l
1,198Annotation score:
G3UXR9G3UXR9_MOUSE
Protein MMS22-like
Mms22l
734Annotation score:
G3UYM2G3UYM2_MOUSE
Protein MMS22-like
Mms22l
101Annotation score:
G5E925G5E925_MOUSE
MCG113554
Mms22l mCG_113554
202Annotation score:
G3UXE4G3UXE4_MOUSE
Protein MMS22-like
Mms22l
323Annotation score:

Sequence cautioni

The sequence AAI37911 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI45029 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0404451 – 276Missing in isoform 2. 1 PublicationAdd BLAST276
Alternative sequenceiVSP_040446793N → NS in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY512923 mRNA Translation: AAR87794.1
BX296536, AL671913 Genomic DNA Translation: CAM23327.1
BC051674 mRNA Translation: AAH51674.1
BC137910 mRNA Translation: AAI37911.1 Different initiation.
BC145028 mRNA Translation: AAI45029.1 Different initiation.
CCDSiCCDS18006.2 [B1AUR6-1]
RefSeqiNP_955761.2, NM_199467.2 [B1AUR6-1]
UniGeneiMm.120919

Genome annotation databases

EnsembliENSMUST00000108222; ENSMUSP00000103857; ENSMUSG00000045751 [B1AUR6-1]
GeneIDi212377
KEGGimmu:212377
UCSCiuc008sdv.2 mouse [B1AUR6-1]
uc008sdy.1 mouse [B1AUR6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY512923 mRNA Translation: AAR87794.1
BX296536, AL671913 Genomic DNA Translation: CAM23327.1
BC051674 mRNA Translation: AAH51674.1
BC137910 mRNA Translation: AAI37911.1 Different initiation.
BC145028 mRNA Translation: AAI45029.1 Different initiation.
CCDSiCCDS18006.2 [B1AUR6-1]
RefSeqiNP_955761.2, NM_199467.2 [B1AUR6-1]
UniGeneiMm.120919

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229314, 1 interactor
STRINGi10090.ENSMUSP00000103857

PTM databases

iPTMnetiB1AUR6
PhosphoSitePlusiB1AUR6

Proteomic databases

EPDiB1AUR6
MaxQBiB1AUR6
PaxDbiB1AUR6
PeptideAtlasiB1AUR6
PRIDEiB1AUR6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000108222; ENSMUSP00000103857; ENSMUSG00000045751 [B1AUR6-1]
GeneIDi212377
KEGGimmu:212377
UCSCiuc008sdv.2 mouse [B1AUR6-1]
uc008sdy.1 mouse [B1AUR6-2]

Organism-specific databases

CTDi253714
MGIiMGI:2684980 Mms22l

Phylogenomic databases

eggNOGiENOG410IEVD Eukaryota
ENOG410ZSY3 LUCA
GeneTreeiENSGT00390000011769
HOGENOMiHOG000049190
HOVERGENiHBG058755
InParanoidiB1AUR6
OMAiYQFDRHG
OrthoDBiEOG091G04DE
PhylomeDBiB1AUR6
TreeFamiTF353832

Miscellaneous databases

ChiTaRSiMms22l mouse
PROiPR:B1AUR6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045751 Expressed in 167 organ(s), highest expression level in embryonic stem cell
ExpressionAtlasiB1AUR6 baseline and differential
GenevisibleiB1AUR6 MM

Family and domain databases

InterProiView protein in InterPro
IPR029424 MMS22L_C
IPR029425 MMS22L_N
PfamiView protein in Pfam
PF14911 MMS22L_C, 1 hit
PF14910 MMS22L_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMMS22_MOUSE
AccessioniPrimary (citable) accession number: B1AUR6
Secondary accession number(s): B7ZN61
, D3YXA0, Q6R5F9, Q80UT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: April 8, 2008
Last modified: November 7, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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