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Protein
Submitted name:

Ski oncogene

Gene

Ski

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-201451 Signaling by BMP
R-MMU-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity

Names & Taxonomyi

Protein namesi
Submitted name:
Ski oncogeneImported
Submitted name:
Sloan-Kettering viral oncogene homologImported
Gene namesi
Name:SkiImported
ORF Names:mCG_3931Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:98310 Ski

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSMUSG00000029050 Expressed in 289 organ(s), highest expression level in primary oocyte

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini217 – 312c-SKI_SMAD_bindInterPro annotationAdd BLAST96

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili594 – 646Sequence analysisAdd BLAST53
Coiled coili659 – 707Sequence analysisAdd BLAST49

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410IFDK Eukaryota
ENOG410Y8AU LUCA
GeneTreeiENSGT00530000063040
HOGENOMiHOG000039989
HOVERGENiHBG006599
OMAiQEQLWPK
OrthoDBiEOG091G0O02
TreeFamiTF324133

Family and domain databases

Gene3Di3.10.260.20, 1 hit
3.10.390.10, 1 hit
InterProiView protein in InterPro
IPR014890 c-SKI_SMAD4-bd_dom
IPR009061 DNA-bd_dom_put_sf
IPR010919 SAND-like_dom_sf
IPR028760 Ski
IPR003380 SKI/SNO/DAC
IPR037000 Ski_DNA-bd_sf
IPR023216 Tscrpt_reg_SKI_SnoN
PANTHERiPTHR10005 PTHR10005, 1 hit
PTHR10005:SF15 PTHR10005:SF15, 1 hit
PfamiView protein in Pfam
PF08782 c-SKI_SMAD_bind, 1 hit
PF02437 Ski_Sno, 1 hit
SMARTiView protein in SMART
SM01046 c-SKI_SMAD_bind, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
SSF63763 SSF63763, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

B1AUF1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAAAAGRGG FQPHPGLQKT LEQFHLSSMS SLGGPAAFSA RWAQEAYKKE
60 70 80 90 100
SAKEAGAATV PAPVPTAAEP PPVLHLPAIQ PPPPVLPGPF FMPSDRSTER
110 120 130 140 150
CETVLEGETI SCFVVGGEKR LCLPQILNSV LRDFSLQQIN SVCDELHIYC
160 170 180 190 200
SRCTADQLEI LKVMGILPFS APSCGLITKT DAERLCNALL YGGAYPPPCK
210 220 230 240 250
KELAASLALG LELSERSVRV YHECFGKCKG LLVPELYSSP SAACIQCLDC
260 270 280 290 300
RLMYPPHKFV VHSHKALENR TCHWGFDSAN WRAYILLSQD YTGKEEQARL
310 320 330 340 350
GRCLDDVKEK FDYANKYKRR VPRVSEPPAS IRPKTDDTSS QSPASSEKDK
360 370 380 390 400
QSTWLRTLAG SSNKSLGCTH PRQRLSAFRP WSPAVSASEK ETSPHLPALI
410 420 430 440 450
RDSFYSYKSF ETAVAPNVAL APPTQQKVVN SPPCTTVVSR APEPLTTCIQ
460 470 480 490 500
PRKRKLTLDT AGAPDMLTPV AAAEEDKDSE AEVEVESREE FTSSLSSLSS
510 520 530 540 550
PSFTSSSSAK DLSSPGMHAP PVVAPDAAAH VDAPSGLEAE LEHLRQALEG
560 570 580 590 600
GLDTKEAKEK FLHEVVKMRV KQEEKLTAAL QAKRSLHQEL EFLRVAKKEK
610 620 630 640 650
LREATEAKRS LRKEIERLRA ENEKKMKEAN ESRVRLKREL EQARQVRVCD
660 670 680 690 700
KGCEAGRLRA KYSAQIEDLQ AKLQHAEADR EQLRADLLRE REAREHLEKV
710 720
VRELQEQLRP RPRPEHPGGE SNAELGP
Length:727
Mass (Da):80,361
Last modified:April 8, 2008 - v1
Checksum:i2D8B41CEA87BBBFE
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q60698SKI_MOUSE
Ski oncogene
Ski
725Annotation score:
B1AUF2B1AUF2_MOUSE
Ski oncogene
Ski
675Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL670413 Genomic DNA No translation available.
CH466594 Genomic DNA Translation: EDL14997.1
RefSeqiNP_035515.2, NM_011385.2
UniGeneiMm.28520

Genome annotation databases

EnsembliENSMUST00000030917; ENSMUSP00000030917; ENSMUSG00000029050
GeneIDi20481
UCSCiuc008wcz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL670413 Genomic DNA No translation available.
CH466594 Genomic DNA Translation: EDL14997.1
RefSeqiNP_035515.2, NM_011385.2
UniGeneiMm.28520

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030917; ENSMUSP00000030917; ENSMUSG00000029050
GeneIDi20481
UCSCiuc008wcz.1 mouse

Organism-specific databases

CTDi6497
MGIiMGI:98310 Ski

Phylogenomic databases

eggNOGiENOG410IFDK Eukaryota
ENOG410Y8AU LUCA
GeneTreeiENSGT00530000063040
HOGENOMiHOG000039989
HOVERGENiHBG006599
OMAiQEQLWPK
OrthoDBiEOG091G0O02
TreeFamiTF324133

Enzyme and pathway databases

ReactomeiR-MMU-201451 Signaling by BMP
R-MMU-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity

Miscellaneous databases

ChiTaRSiSki mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029050 Expressed in 289 organ(s), highest expression level in primary oocyte

Family and domain databases

Gene3Di3.10.260.20, 1 hit
3.10.390.10, 1 hit
InterProiView protein in InterPro
IPR014890 c-SKI_SMAD4-bd_dom
IPR009061 DNA-bd_dom_put_sf
IPR010919 SAND-like_dom_sf
IPR028760 Ski
IPR003380 SKI/SNO/DAC
IPR037000 Ski_DNA-bd_sf
IPR023216 Tscrpt_reg_SKI_SnoN
PANTHERiPTHR10005 PTHR10005, 1 hit
PTHR10005:SF15 PTHR10005:SF15, 1 hit
PfamiView protein in Pfam
PF08782 c-SKI_SMAD_bind, 1 hit
PF02437 Ski_Sno, 1 hit
SMARTiView protein in SMART
SM01046 c-SKI_SMAD_bind, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
SSF63763 SSF63763, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB1AUF1_MOUSE
AccessioniPrimary (citable) accession number: B1AUF1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: November 7, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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