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Protein
Submitted name:

Purinergic receptor P2X, ligand-gated ion channel, 5

Gene

P2rx5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

  • ATP binding Source: MGI
  • ATP-gated ion channel activity Source: GO_Central
  • drug binding Source: MGI
  • extracellularly ATP-gated cation channel activity Source: MGI
  • GTP binding Source: MGI
  • purinergic nucleotide receptor activity Source: GO_Central
  • zinc ion binding Source: MGI

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-139853 Elevation of cytosolic Ca2+ levels
R-MMU-418346 Platelet homeostasis

Names & Taxonomyi

Protein namesi
Submitted name:
Purinergic receptor P2X, ligand-gated ion channel, 5Imported
Gene namesi
Name:P2rx5Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2137026 P2rx5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei31 – 51HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiB1AUD6

Expressioni

Gene expression databases

BgeeiENSMUSG00000005950 Expressed in 119 organ(s), highest expression level in brown adipose tissue
ExpressionAtlasiB1AUD6 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliB1AUD6
SMRiB1AUD6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

GeneTreeiENSGT00390000016028
HOGENOMiHOG000232042
HOVERGENiHBG053086

Family and domain databases

Gene3Di2.60.490.10, 2 hits
InterProiView protein in InterPro
IPR003048 P2X5_purnocptor
IPR027309 P2X_extracellular_dom_sf
IPR001429 P2X_purnocptor
PANTHERiPTHR10125 PTHR10125, 2 hits
PTHR10125:SF12 PTHR10125:SF12, 2 hits
PfamiView protein in Pfam
PF00864 P2X_receptor, 2 hits
PIRSFiPIRSF005713 P2X_purinoceptor, 3 hits
PRINTSiPR01312 P2X5RECEPTOR
PR01307 P2XRECEPTOR
TIGRFAMsiTIGR00863 P2X, 1 hit
PROSITEiView protein in PROSITE
PS01212 P2X_RECEPTOR, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

B1AUD6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQAAWKGFV LSLFDYKTAK FVVAKSKKVG LLYRVLQLTI LLYLLIWVFL
60 70 80 90 100
IKKSYQDIDT SLQSAVVTKV KGVAYTNTTM LGERLWDVAD FVIPSQREGI
110 120 130 140 150
PDGECSEDTD CHAGESVVAG HGLKTGRCLR VGNSTRGTCE IFAWCPVETK
160 170 180 190 200
SMPTDPLLKD AEGFTIFIKN FIRFPKFNFS KANVLETGNK HFLKTCHFSS
210 220 230 240 250
TNLYCPIFRL GSIVRWAGAD FQDIALKGGV IGIHIEWDCD LDKAASHCNP
260 270 280 290 300
HYYFNRLDNK HTQSISSGYN FRFARYYRDP HGVEFRDLMK AYGIRFDVIV
310 320 330
NGKGAFFCDL VLIYLIRKSE FYRDKKFEKV
Length:330
Mass (Da):37,600
Last modified:April 8, 2008 - v1
Checksum:i390213DAE054EFEC
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3UYI1Q3UYI1_MOUSE
P2X purinoceptor
P2rx5 mCG_125429
455Annotation score:
B1AUD7B1AUD7_MOUSE
p2X purinoceptor
P2rx5
354Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei330Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL670399 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000135202; ENSMUSP00000118448; ENSMUSG00000005950

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL670399 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliB1AUD6
SMRiB1AUD6
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiB1AUD6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000135202; ENSMUSP00000118448; ENSMUSG00000005950

Organism-specific databases

MGIiMGI:2137026 P2rx5

Phylogenomic databases

GeneTreeiENSGT00390000016028
HOGENOMiHOG000232042
HOVERGENiHBG053086

Enzyme and pathway databases

ReactomeiR-MMU-139853 Elevation of cytosolic Ca2+ levels
R-MMU-418346 Platelet homeostasis

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005950 Expressed in 119 organ(s), highest expression level in brown adipose tissue
ExpressionAtlasiB1AUD6 baseline and differential

Family and domain databases

Gene3Di2.60.490.10, 2 hits
InterProiView protein in InterPro
IPR003048 P2X5_purnocptor
IPR027309 P2X_extracellular_dom_sf
IPR001429 P2X_purnocptor
PANTHERiPTHR10125 PTHR10125, 2 hits
PTHR10125:SF12 PTHR10125:SF12, 2 hits
PfamiView protein in Pfam
PF00864 P2X_receptor, 2 hits
PIRSFiPIRSF005713 P2X_purinoceptor, 3 hits
PRINTSiPR01312 P2X5RECEPTOR
PR01307 P2XRECEPTOR
TIGRFAMsiTIGR00863 P2X, 1 hit
PROSITEiView protein in PROSITE
PS01212 P2X_RECEPTOR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB1AUD6_MOUSE
AccessioniPrimary (citable) accession number: B1AUD6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: November 7, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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