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Protein
Submitted name:

Short transient receptor potential channel 3

Gene

Trpc3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channelSAAS annotation, ReceptorImported
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-114508 Effects of PIP2 hydrolysis
R-MMU-139853 Elevation of cytosolic Ca2+ levels
R-MMU-3295583 TRP channels

Names & Taxonomyi

Protein namesi
Submitted name:
Short transient receptor potential channel 3Imported
Submitted name:
Transient receptor potential cation channel, subfamily C, member 3Imported
Gene namesi
Name:Trpc3Imported
ORF Names:CT7-314H19.1-001Imported, mCG_14063Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:109526 Trpc3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei408 – 432HelicalSequence analysisAdd BLAST25
Transmembranei444 – 464HelicalSequence analysisAdd BLAST21
Transmembranei495 – 512HelicalSequence analysisAdd BLAST18
Transmembranei533 – 554HelicalSequence analysisAdd BLAST22
Transmembranei642 – 662HelicalSequence analysisAdd BLAST21
Transmembranei710 – 732HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000027716 Expressed in 136 organ(s), highest expression level in cerebellum lobe

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 158ANK_REP_REGIONInterPro annotationAdd BLAST51

Sequence similaritiesi

Belongs to the transient receptor (TC 1.A.4) family. [View classification]SAAS annotation

Keywords - Domaini

ANK repeatSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3609 Eukaryota
ENOG410XQ0Y LUCA
GeneTreeiENSGT00760000119180
HOGENOMiHOG000020590
HOVERGENiHBG068337
KOiK04966
OMAiTVTDYPK
OrthoDBiEOG091G01FB
TreeFamiTF313147

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR013555 TRP_dom
IPR005459 TRPC3_channel
IPR002153 TRPC_channel
PANTHERiPTHR10117 PTHR10117, 1 hit
PTHR10117:SF8 PTHR10117:SF8, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00520 Ion_trans, 1 hit
PF08344 TRP_2, 1 hit
PRINTSiPR01097 TRNSRECEPTRP
PR01644 TRPCHANNEL3
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

B1ATV3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTKVKKCRE PARVTLPAPE EEEDGEAEGG ESQRRRRGWR GVNGGLEPPC
60 70 80 90 100
PRAPPSPGPD ASSEGSPSRW RTAGMRDKGR RQAVRGPAFM FGARGPSLTA
110 120 130 140 150
EEERFLDAAE YGNIPVVRKM LEESRTLNVN CVDYMGQNAL QLAVGNEHLE
160 170 180 190 200
VTELLLKKEN LARIGDALLL AISKGYVRIV EAILGHPGFA ASRRLTLSPC
210 220 230 240 250
EQELRDDDFY AYDEDGTRFS PDITPIILAA HCHKYEVVHL LLLKGARIER
260 270 280 290 300
PHDYFCRCSD CAEKQRLDAF SHSRSRINAY KGLASPAYLS LSSEDPVLTA
310 320 330 340 350
LELSNELAKL ANIEKEFKND YRKLSMQCKD FVVGVLDLCR DSEEVEAILN
360 370 380 390 400
GDLESAEPLE RHGHKASLSR VKLAIKYEVK KFVAHPNCQQ QLLTIWYENL
410 420 430 440 450
SGLREQTIAI KCLVVLVVAL GLPFLAIGYW IAPCSRLGKI LRSPFMKFVA
460 470 480 490 500
HAASFIIFLG LLVFNASDRF EGITTLPNIT VIDYPKQIFR VKTTQFTWTE
510 520 530 540 550
MLIMVWVLGM MWSECKELWL EGPREYIVQL WNVLDFGMLS IFIAAFTARF
560 570 580 590 600
LAFLQATKAQ QYVDSHVQES DLSEVTLPPE VQYFTYARDK WLPSDPQIIS
610 620 630 640 650
EGLYAIAVVL SFSRIAYILP ANESFGPLQI SLGRTVKDIF KFMVLFIMVF
660 670 680 690 700
LAFMIGMFIL YSYYLGAKVN PAFTTVEESF KTLFWSIFGL SEVTSVVLKY
710 720 730 740 750
DHKFIENIGY VLYGIYNVTM VVVLLNMLIA MINSSYQEIE DDSDVEWKFA
760 770 780 790 800
RSKLWLSYFD DGKTLPPPFS LVPSPKSFVY FIMRITNFSK CRRRRLQKDL
810 820 830 840 850
ELGMGNSKSR LNLFTQSNSR VFESHSFNSI LNQPTRYQQI MKRLIKRYVL
860 870 880 890 900
KAQVDKENDE VNEGELKEIK QDISSLRYEL LEDKSQATEE LAILIHKLSE
910
KLNPSVLRCE
Length:910
Mass (Da):103,620
Last modified:April 8, 2008 - v1
Checksum:i3773375324F0E67C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9QZC1TRPC3_MOUSE
Short transient receptor potential ...
Trpc3 Trp3, Trrp3
836Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117584 Genomic DNA No translation available.
AL663106 Genomic DNA Translation: CAM28054.1
CH466530 Genomic DNA Translation: EDL35089.1
RefSeqiNP_062383.2, NM_019510.2
UniGeneiMm.74363

Genome annotation databases

EnsembliENSMUST00000029271; ENSMUSP00000029271; ENSMUSG00000027716
GeneIDi22065
KEGGimmu:22065
UCSCiuc008ozt.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117584 Genomic DNA No translation available.
AL663106 Genomic DNA Translation: CAM28054.1
CH466530 Genomic DNA Translation: EDL35089.1
RefSeqiNP_062383.2, NM_019510.2
UniGeneiMm.74363

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029271; ENSMUSP00000029271; ENSMUSG00000027716
GeneIDi22065
KEGGimmu:22065
UCSCiuc008ozt.2 mouse

Organism-specific databases

CTDi7222
MGIiMGI:109526 Trpc3

Phylogenomic databases

eggNOGiKOG3609 Eukaryota
ENOG410XQ0Y LUCA
GeneTreeiENSGT00760000119180
HOGENOMiHOG000020590
HOVERGENiHBG068337
KOiK04966
OMAiTVTDYPK
OrthoDBiEOG091G01FB
TreeFamiTF313147

Enzyme and pathway databases

ReactomeiR-MMU-114508 Effects of PIP2 hydrolysis
R-MMU-139853 Elevation of cytosolic Ca2+ levels
R-MMU-3295583 TRP channels

Miscellaneous databases

ChiTaRSiTrpc3 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027716 Expressed in 136 organ(s), highest expression level in cerebellum lobe

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR013555 TRP_dom
IPR005459 TRPC3_channel
IPR002153 TRPC_channel
PANTHERiPTHR10117 PTHR10117, 1 hit
PTHR10117:SF8 PTHR10117:SF8, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00520 Ion_trans, 1 hit
PF08344 TRP_2, 1 hit
PRINTSiPR01097 TRNSRECEPTRP
PR01644 TRPCHANNEL3
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB1ATV3_MOUSE
AccessioniPrimary (citable) accession number: B1ATV3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: November 7, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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