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Entry version 78 (07 Apr 2021)
Sequence version 1 (08 Apr 2008)
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Protein

Proline-rich protein 32

Gene

PRR32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
B1ATL7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proline-rich protein 32
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRR32
Synonyms:CXorf64
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:34498, PRR32

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_B1ATL7

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000183631.4

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
100130613

Open Targets

More...
OpenTargetsi
ENSG00000183631

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162383082

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
B1ATL7, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PRR32

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003361021 – 298Proline-rich protein 32Add BLAST298

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
B1ATL7

PRoteomics IDEntifications database

More...
PRIDEi
B1ATL7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
3352

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
B1ATL7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
B1ATL7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000183631, Expressed in colon and 55 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
B1ATL7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000183631, Group enriched (heart muscle, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
934805, 5 interactors

Protein interaction database and analysis system

More...
IntActi
B1ATL7, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000360166

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
B1ATL7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B1ATL7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi214 – 293Pro-richAdd BLAST80

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502T9EE, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012726

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_933713_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B1ATL7

Identification of Orthologs from Complete Genome Data

More...
OMAi
CFIPPRP

Database of Orthologous Groups

More...
OrthoDBi
1300193at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B1ATL7

TreeFam database of animal gene trees

More...
TreeFami
TF338131

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027891, DUF4645

The PANTHER Classification System

More...
PANTHERi
PTHR37343, PTHR37343, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15488, DUF4645, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B1ATL7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MACIENVLGG HAPSPLVVSV DKNGNQELHH DMPLQCLSSK PEDDAEPWGQ
60 70 80 90 100
PQVPLRPSVN VLTDLDSKQL EWPSERTGSC IPLHSLRAHR HPYGPPPAVA
110 120 130 140 150
EESLATAEVN SSDALAGWRQ EGQDAINVSW EVSGGPPALI VGGTKVNNGG
160 170 180 190 200
TERGSNNARL HVALPQGKGF FPPRGPQVRG PSHIPTLRSG IVMEVPPGNT
210 220 230 240 250
RIACRGKLAH VSFPLRGPCH PMHNWPRPIP LSSSTPGLPS CSTVHCFIPP
260 270 280 290
RPPIFNPFLT MPLPFAPPPI FGPPLPSYFA HFHSGGMPAP ASPNREHS
Length:298
Mass (Da):31,890
Last modified:April 8, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4CE1F2CB6F195D28
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061638115L → V. Corresponds to variant dbSNP:rs12835991Ensembl.1
Natural variantiVAR_059650193M → T. Corresponds to variant dbSNP:rs4289953Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL662896 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS48163.1

NCBI Reference Sequences

More...
RefSeqi
NP_001116188.1, NM_001122716.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000371125; ENSP00000360166; ENSG00000183631

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100130613

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:100130613

UCSC genome browser

More...
UCSCi
uc010nra.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662896 Genomic DNA No translation available.
CCDSiCCDS48163.1
RefSeqiNP_001116188.1, NM_001122716.1

3D structure databases

SMRiB1ATL7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi934805, 5 interactors
IntActiB1ATL7, 4 interactors
STRINGi9606.ENSP00000360166

PTM databases

iPTMnetiB1ATL7
PhosphoSitePlusiB1ATL7

Genetic variation databases

BioMutaiPRR32

Proteomic databases

PaxDbiB1ATL7
PRIDEiB1ATL7
ProteomicsDBi3352

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
57821, 4 antibodies

Genome annotation databases

EnsembliENST00000371125; ENSP00000360166; ENSG00000183631
GeneIDi100130613
KEGGihsa:100130613
UCSCiuc010nra.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100130613
DisGeNETi100130613

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PRR32
HGNCiHGNC:34498, PRR32
HPAiENSG00000183631, Group enriched (heart muscle, tongue)
neXtProtiNX_B1ATL7
OpenTargetsiENSG00000183631
PharmGKBiPA162383082
VEuPathDBiHostDB:ENSG00000183631.4

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502T9EE, Eukaryota
GeneTreeiENSGT00390000012726
HOGENOMiCLU_933713_0_0_1
InParanoidiB1ATL7
OMAiCFIPPRP
OrthoDBi1300193at2759
PhylomeDBiB1ATL7
TreeFamiTF338131

Enzyme and pathway databases

PathwayCommonsiB1ATL7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
100130613, 6 hits in 605 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
100130613
PharosiB1ATL7, Tdark

Protein Ontology

More...
PROi
PR:B1ATL7
RNActiB1ATL7, protein

Gene expression databases

BgeeiENSG00000183631, Expressed in colon and 55 other tissues
GenevisibleiB1ATL7, HS

Family and domain databases

InterProiView protein in InterPro
IPR027891, DUF4645
PANTHERiPTHR37343, PTHR37343, 1 hit
PfamiView protein in Pfam
PF15488, DUF4645, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRR32_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B1ATL7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: April 7, 2021
This is version 78 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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