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Protein

Metalloprotease TIKI2

Gene

Trabd2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation (By similarity).By similarity

Cofactori

Mn2+By similarity, Co2+By similarityNote: Divalent metal cations. Mn2+ or Co2+.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
Biological processWnt signaling pathway
LigandMetal-binding

Protein family/group databases

MEROPSiM96.002

Names & Taxonomyi

Protein namesi
Recommended name:
Metalloprotease TIKI2 (EC:3.4.-.-)
Alternative name(s):
Heart, kidney and adipose-enriched transmembrane protein
TRAB domain-containing protein 2B
Gene namesi
Name:Trabd2b
Synonyms:Gm12824, Hkat, Tiki2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:3650152 Trabd2b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 494ExtracellularSequence analysisAdd BLAST475
Transmembranei495 – 515HelicalSequence analysisAdd BLAST21
Topological domaini516 – 517CytoplasmicSequence analysis2

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000034643720 – 517Metalloprotease TIKI2Add BLAST498

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi227N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi334N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiB1ATG9
PRIDEiB1ATG9

PTM databases

iPTMnetiB1ATG9
PhosphoSitePlusiB1ATG9

Expressioni

Tissue specificityi

Highly expressed in heart and kidney. Also found in white and brown adipose tissue.1 Publication

Inductioni

Transiently induced during 3T3-L1 cell differentiation into adipocytes. In vivo, down-regulated by fasting in both white and brown adipose tissues. High-fat diet down-regulates expression in white adipose tissue and up-regulates it in brown adipose tissue.1 Publication

Gene expression databases

BgeeiENSMUSG00000070867 Expressed in 174 organ(s), highest expression level in adult mammalian kidney
GenevisibleiB1ATG9 MM

Interactioni

GO - Molecular functioni

Family & Domainsi

Sequence similaritiesi

Belongs to the TIKI family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF3M Eukaryota
ENOG410ZH8D LUCA
GeneTreeiENSGT00390000017525
HOGENOMiHOG000154747
HOVERGENiHBG108634
InParanoidiB1ATG9
OMAiLWTIRRH
OrthoDBiEOG091G0AY8
PhylomeDBiB1ATG9
TreeFamiTF313392

Family and domain databases

InterProiView protein in InterPro
IPR002816 Pheromone_shutdown_TraB
PfamiView protein in Pfam
PF01963 TraB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B1ATG9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHAALAGPLL AALLATARAR PQPPDGGQCR PPGSQRDLNS FLWTIRRHPP
60 70 80 90 100
AYLFGTIHVP YTRVWDFIPD NSKAAFQAST HVYFELDLTD PYTISALASC
110 120 130 140 150
QLLPHGENLQ DVLPRELYWR LKRHLDYVKL MIPSWMTPAQ RGKGLYADYL
160 170 180 190 200
FNAIAGNWER KRPVWVMLMV NSLTETDVRS RGVPVLDLYL AQQAEKMKKS
210 220 230 240 250
TGAVERVEEQ CHPLNGLNFS QVLFALNQTL LQHESVRAGS LQAPYTTEDL
260 270 280 290 300
IKHYNCGDLN AVIFNHDTSQ LPNFINTTLP PHEQVTAQEI DSYFRQELIY
310 320 330 340 350
KRNERMGKRV MALLQENQDK ICFFAFGAGH FLGNNTVIDV LRQAGLEVDH
360 370 380 390 400
TPAGQAIHGP AAVGSPAPPP EITSPASPAP ATPAAAVPEA TSATPTTPPE
410 420 430 440 450
EEDPVLSPHL LLPDSLSQLE EFGRQKWRKR LNKHQRPRQF NDLWVRIEDS
460 470 480 490 500
TTISPPPLPL QPTPSSETTK PFVKSSHQLQ QQDAVGPTSS SAPTLGLLHA
510
ITASIVAPFL LHSLGPS
Length:517
Mass (Da):57,368
Last modified:April 8, 2008 - v1
Checksum:i5F1284F6B398D9DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL646006, AL670175 Genomic DNA Translation: CAM16094.1
AL670175, AL646006 Genomic DNA Translation: CAM20425.1
CCDSiCCDS38843.1
RefSeqiNP_001079018.1, NM_001085549.1
UniGeneiMm.331779

Genome annotation databases

EnsembliENSMUST00000094894; ENSMUSP00000092494; ENSMUSG00000070867
GeneIDi666048
KEGGimmu:666048
UCSCiuc008ueb.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL646006, AL670175 Genomic DNA Translation: CAM16094.1
AL670175, AL646006 Genomic DNA Translation: CAM20425.1
CCDSiCCDS38843.1
RefSeqiNP_001079018.1, NM_001085549.1
UniGeneiMm.331779

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM96.002

PTM databases

iPTMnetiB1ATG9
PhosphoSitePlusiB1ATG9

Proteomic databases

PaxDbiB1ATG9
PRIDEiB1ATG9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094894; ENSMUSP00000092494; ENSMUSG00000070867
GeneIDi666048
KEGGimmu:666048
UCSCiuc008ueb.1 mouse

Organism-specific databases

CTDi388630
MGIiMGI:3650152 Trabd2b

Phylogenomic databases

eggNOGiENOG410IF3M Eukaryota
ENOG410ZH8D LUCA
GeneTreeiENSGT00390000017525
HOGENOMiHOG000154747
HOVERGENiHBG108634
InParanoidiB1ATG9
OMAiLWTIRRH
OrthoDBiEOG091G0AY8
PhylomeDBiB1ATG9
TreeFamiTF313392

Miscellaneous databases

PROiPR:B1ATG9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000070867 Expressed in 174 organ(s), highest expression level in adult mammalian kidney
GenevisibleiB1ATG9 MM

Family and domain databases

InterProiView protein in InterPro
IPR002816 Pheromone_shutdown_TraB
PfamiView protein in Pfam
PF01963 TraB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTIKI2_MOUSE
AccessioniPrimary (citable) accession number: B1ATG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: April 8, 2008
Last modified: November 7, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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