UniProtKB - B1AT66 (MOT7_MOUSE)
Protein
Monocarboxylate transporter 7
Gene
Slc16a6
Organism
Mus musculus (Mouse)
Status
Functioni
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).By similarity
GO - Molecular functioni
- monocarboxylic acid transmembrane transporter activity Source: GO_Central
- symporter activity Source: UniProtKB-KW
GO - Biological processi
- monocarboxylic acid transport Source: GO_Central
Keywordsi
Biological process | Symport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Monocarboxylate transporter 7Short name: MCT 7 Alternative name(s): Monocarboxylate transporter 6 Short name: MCT 6 Solute carrier family 16 member 6 |
Gene namesi | Name:Slc16a6 Synonyms:Mct7 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2144585, Slc16a6 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 105 | CytoplasmicSequence analysisAdd BLAST | 105 | |
Transmembranei | 106 – 126 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 127 – 146 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 147 – 167 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 168 – 175 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 176 – 196 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 197 – 202 | ExtracellularSequence analysis | 6 | |
Transmembranei | 203 – 223 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 224 – 233 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 234 – 254 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 255 – 268 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 269 – 289 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 290 – 383 | CytoplasmicSequence analysisAdd BLAST | 94 | |
Transmembranei | 384 – 404 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 405 – 414 | ExtracellularSequence analysis | 10 | |
Transmembranei | 415 – 435 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 436 – 442 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 443 – 463 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 464 – 465 | ExtracellularSequence analysis | 2 | |
Transmembranei | 466 – 486 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 487 – 507 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 508 – 528 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 529 – 536 | ExtracellularSequence analysis | 8 | |
Transmembranei | 537 – 557 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 558 – 607 | CytoplasmicSequence analysisAdd BLAST | 50 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000416126 | 1 – 607 | Monocarboxylate transporter 7Add BLAST | 607 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 319 | PhosphoserineCombined sources | 1 | |
Modified residuei | 322 | PhosphoserineCombined sources | 1 | |
Modified residuei | 325 | PhosphoserineCombined sources | 1 | |
Modified residuei | 332 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | B1AT66 |
PaxDbi | B1AT66 |
PeptideAtlasi | B1AT66 |
PRIDEi | B1AT66 |
PTM databases
iPTMneti | B1AT66 |
PhosphoSitePlusi | B1AT66 |
SwissPalmi | B1AT66 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000041920, Expressed in lobe of liver and 271 other tissues |
ExpressionAtlasi | B1AT66, baseline and differential |
Genevisiblei | B1AT66, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000065628 |
Miscellaneous databases
RNActi | B1AT66, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2504, Eukaryota |
GeneTreei | ENSGT00940000155575 |
HOGENOMi | CLU_001265_59_1_1 |
InParanoidi | B1AT66 |
OrthoDBi | 916876at2759 |
PhylomeDBi | B1AT66 |
TreeFami | TF313792 |
Family and domain databases
InterProi | View protein in InterPro IPR030766, MCT7 IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
PANTHERi | PTHR11360:SF20, PTHR11360:SF20, 1 hit |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: B1AT66-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRASGQGPQR RRRGWATRDD SAVTFRDPQP RQPAGGARAL RGPDPRGPAR
60 70 80 90 100
AHQAGPLLAG ARRSQHMVGG APPRPAETGC SRSRMTQKNS KLCARANVYT
110 120 130 140 150
QVPDGGWGWA VAVSFFFVEV FTYGIIKSFG VFFNDLMDSF DESNSKISWI
160 170 180 190 200
ISICVFVLTF TAPLSTVLSN RFGHRLVVMA GGLLISLGMI TASFSQRVYH
210 220 230 240 250
MYISIGVISG LGYCFSFLPT VTILSQYFDK RRSVVTAVAS TGECFAVFAF
260 270 280 290 300
APAITALKEH IGWRYSLLFV GLLQLNIMVC GALLRPIIIQ GPGQSPKAVT
310 320 330 340 350
LEPRREVQYM LENEKTRTSI DSIDSGVELT TSPKNVPSEA KMEQETRAEQ
360 370 380 390 400
QQTLVTAPKH SQMKAPLLDF SVLKEKSFIC YALFGLFATL GFFAPSLYII
410 420 430 440 450
PLGISLGIDP DRAAFLLSTM AIAEVFGRIG AGFVLNREPI RKIYIELICV
460 470 480 490 500
ILLTASLFAF TFATEFWGLM LCSVFFGSMV GTIGGTHIPM LAEDDVVGIE
510 520 530 540 550
KMSSAAGVYV FIQSISGLAG PPLAGLLVDQ SKIYSRAFYS CAAGMCLAAV
560 570 580 590 600
CLALVRPCKK GLCQNSHSGE NQTDRQRGKA LQDIPEDFLE MDLGKCEHRA
HMKMDPV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH9KV19 | H9KV19_MOUSE | Monocarboxylate transporter 7 | Slc16a6 | 141 | Annotation score: | ||
H9KUY0 | H9KUY0_MOUSE | Monocarboxylate transporter 7 | Slc16a6 | 113 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 37 | A → T in BAC27657 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 243 | E → D in BAC27657 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 302 | E → K in BAE41817 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042512 | 1 – 84 | Missing in isoform 2. 2 PublicationsAdd BLAST | 84 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK032026 mRNA Translation: BAC27657.1 AK170472 mRNA Translation: BAE41817.1 AL645791 Genomic DNA No translation available. CH466558 Genomic DNA Translation: EDL34359.1 CH466558 Genomic DNA Translation: EDL34361.1 BC017129 mRNA Translation: AAH17129.1 |
CCDSi | CCDS25580.1 [B1AT66-1] CCDS36360.1 [B1AT66-2] |
RefSeqi | NP_001025013.1, NM_001029842.1 [B1AT66-1] NP_598799.1, NM_134038.2 [B1AT66-2] XP_006532010.1, XM_006531947.2 |
Genome annotation databases
Ensembli | ENSMUST00000070152; ENSMUSP00000065628; ENSMUSG00000041920 [B1AT66-1] ENSMUST00000070872; ENSMUSP00000067423; ENSMUSG00000041920 [B1AT66-2] |
GeneIDi | 104681 |
KEGGi | mmu:104681 |
UCSCi | uc007mcl.1, mouse [B1AT66-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK032026 mRNA Translation: BAC27657.1 AK170472 mRNA Translation: BAE41817.1 AL645791 Genomic DNA No translation available. CH466558 Genomic DNA Translation: EDL34359.1 CH466558 Genomic DNA Translation: EDL34361.1 BC017129 mRNA Translation: AAH17129.1 |
CCDSi | CCDS25580.1 [B1AT66-1] CCDS36360.1 [B1AT66-2] |
RefSeqi | NP_001025013.1, NM_001029842.1 [B1AT66-1] NP_598799.1, NM_134038.2 [B1AT66-2] XP_006532010.1, XM_006531947.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000065628 |
PTM databases
iPTMneti | B1AT66 |
PhosphoSitePlusi | B1AT66 |
SwissPalmi | B1AT66 |
Proteomic databases
MaxQBi | B1AT66 |
PaxDbi | B1AT66 |
PeptideAtlasi | B1AT66 |
PRIDEi | B1AT66 |
Protocols and materials databases
Antibodypediai | 31766, 39 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000070152; ENSMUSP00000065628; ENSMUSG00000041920 [B1AT66-1] ENSMUST00000070872; ENSMUSP00000067423; ENSMUSG00000041920 [B1AT66-2] |
GeneIDi | 104681 |
KEGGi | mmu:104681 |
UCSCi | uc007mcl.1, mouse [B1AT66-1] |
Organism-specific databases
CTDi | 9120 |
MGIi | MGI:2144585, Slc16a6 |
Phylogenomic databases
eggNOGi | KOG2504, Eukaryota |
GeneTreei | ENSGT00940000155575 |
HOGENOMi | CLU_001265_59_1_1 |
InParanoidi | B1AT66 |
OrthoDBi | 916876at2759 |
PhylomeDBi | B1AT66 |
TreeFami | TF313792 |
Miscellaneous databases
BioGRID-ORCSi | 104681, 0 hits in 17 CRISPR screens |
ChiTaRSi | Slc16a6, mouse |
PROi | PR:B1AT66 |
RNActi | B1AT66, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000041920, Expressed in lobe of liver and 271 other tissues |
ExpressionAtlasi | B1AT66, baseline and differential |
Genevisiblei | B1AT66, MM |
Family and domain databases
InterProi | View protein in InterPro IPR030766, MCT7 IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
PANTHERi | PTHR11360:SF20, PTHR11360:SF20, 1 hit |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MOT7_MOUSE | |
Accessioni | B1AT66Primary (citable) accession number: B1AT66 Secondary accession number(s): D3Z3P6 Q91W47 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 21, 2012 |
Last sequence update: | April 8, 2008 | |
Last modified: | December 2, 2020 | |
This is version 94 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families