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Protein
Submitted name:

Interleukin-1 receptor accessory protein-like 1

Gene

Il1rapl1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-388844 Receptor-type tyrosine-protein phosphatases
R-MMU-9007892 Interleukin-38 signaling

Names & Taxonomyi

Protein namesi
Submitted name:
Interleukin-1 receptor accessory protein-like 1Imported
Gene namesi
Name:Il1rapl1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2687319 Il1rapl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei360 – 381HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_501508703319 – 696Sequence analysisAdd BLAST678

Expressioni

Gene expression databases

BgeeiENSMUSG00000052372 Expressed in 87 organ(s), highest expression level in midbrain mantle layer

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 134Ig-likeInterPro annotationAdd BLAST129
Domaini162 – 232Ig-likeInterPro annotationAdd BLAST71
Domaini242 – 350Ig-likeInterPro annotationAdd BLAST109
Domaini403 – 562TIRInterPro annotationAdd BLAST160

Keywords - Domaini

Immunoglobulin domainSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IF3G Eukaryota
ENOG4110Z8K LUCA
GeneTreeiENSGT00760000119071
HOGENOMiHOG000092977
HOVERGENiHBG052148
KOiK05170
OMAiITHEQVL
OrthoDBiEOG091G0GXW
TreeFamiTF333913

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR015621 IL-1_rcpt_fam
IPR013151 Immunoglobulin
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR11890 PTHR11890, 1 hit
PfamiView protein in Pfam
PF00047 ig, 1 hit
PF01582 TIR, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits
SM00255 TIR, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS50104 TIR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

B1ASU0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKAPIPHLIL LYATFTQSLK VVTKRGSADG CTDWSVDIKK YQVLVGEPVR
60 70 80 90 100
IKCALFYGYI RTNYSLAQSA GLSLMWYKSS GPGDFEEPIA FDGSRMSKEE
110 120 130 140 150
DSIWFRPTLL QDSGLYACVI RNSTYCMKVS ISLTVGENDT GLCYNSKMKY
160 170 180 190 200
FEKAELSKSK EISCRDIEDF LLPTREPEIL WYKECRTKAW RPSIVFKRDT
210 220 230 240 250
LLIKEVKEDD IGNYTCELKY GGFVVRRTTE LTVTAPLTDK PPKLLYPMES
260 270 280 290 300
KLTVQETQLG GSANLTCRAF FGYSGDVSPL IYWMKGEKFI EDLDENRVWE
310 320 330 340 350
SDIRILKEHL GEQEVSISLI VDSVEEGDLG NYSCYVENGN GRRHASVLLH
360 370 380 390 400
KRELMYTVEL AGGLGAILLL LICSVTIYKC YKIEIMLFYR NHFGAEELDG
410 420 430 440 450
DNKDYDAYLS YTKVDPDQWN QETGEEERFA LEILPDMLEK HYGYKLFIPD
460 470 480 490 500
RDLIPTGTYI EDVARCVDQS KRLIIVMTPN YVVRRGWSIF ELETRLRNML
510 520 530 540 550
VTGEIKVILI ECSELRGIMN YQEVEALKHT IKLLTVIKWH GPKCNKLNSK
560 570 580 590 600
FWKRLQYEMP FKRIEPITHE QALDVSEQGP FGELQTVSAI SMAAATSTAL
610 620 630 640 650
ATAHPDLRST FHNTYHSQMR QKHYYRSYEY DVPPTGTLPL TSIGNQHTYC
660 670 680 690
NIPMTLINGQ RPQTKSNREP NPDEAHTNSA ILPLLPRETS ISSVIW
Length:696
Mass (Da):79,780
Last modified:April 8, 2008 - v1
Checksum:iA2CA8D897C5569C1
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P59823IRPL1_MOUSE
Interleukin-1 receptor accessory pr...
Il1rapl1
695Annotation score:
Q0VDP7Q0VDP7_MOUSE
Il1rapl1 protein
Il1rapl1
383Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627409 Genomic DNA No translation available.
AL672059 Genomic DNA No translation available.
AL731705 Genomic DNA No translation available.
AL844869 Genomic DNA No translation available.
AL844900 Genomic DNA No translation available.
BX005231 Genomic DNA No translation available.
BX088567 Genomic DNA No translation available.
BX649618 Genomic DNA No translation available.
BX890584 Genomic DNA No translation available.
CR538724 Genomic DNA No translation available.
RefSeqiNP_001153875.1, NM_001160403.1
UniGeneiMm.121680
Mm.400887
Mm.426143

Genome annotation databases

EnsembliENSMUST00000078875; ENSMUSP00000077915; ENSMUSG00000052372
ENSMUST00000113966; ENSMUSP00000109599; ENSMUSG00000052372
GeneIDi331461
KEGGimmu:331461
UCSCiuc012hln.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627409 Genomic DNA No translation available.
AL672059 Genomic DNA No translation available.
AL731705 Genomic DNA No translation available.
AL844869 Genomic DNA No translation available.
AL844900 Genomic DNA No translation available.
BX005231 Genomic DNA No translation available.
BX088567 Genomic DNA No translation available.
BX649618 Genomic DNA No translation available.
BX890584 Genomic DNA No translation available.
CR538724 Genomic DNA No translation available.
RefSeqiNP_001153875.1, NM_001160403.1
UniGeneiMm.121680
Mm.400887
Mm.426143

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078875; ENSMUSP00000077915; ENSMUSG00000052372
ENSMUST00000113966; ENSMUSP00000109599; ENSMUSG00000052372
GeneIDi331461
KEGGimmu:331461
UCSCiuc012hln.1 mouse

Organism-specific databases

CTDi11141
MGIiMGI:2687319 Il1rapl1

Phylogenomic databases

eggNOGiENOG410IF3G Eukaryota
ENOG4110Z8K LUCA
GeneTreeiENSGT00760000119071
HOGENOMiHOG000092977
HOVERGENiHBG052148
KOiK05170
OMAiITHEQVL
OrthoDBiEOG091G0GXW
TreeFamiTF333913

Enzyme and pathway databases

ReactomeiR-MMU-388844 Receptor-type tyrosine-protein phosphatases
R-MMU-9007892 Interleukin-38 signaling

Miscellaneous databases

ChiTaRSiIl1rapl1 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052372 Expressed in 87 organ(s), highest expression level in midbrain mantle layer

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR015621 IL-1_rcpt_fam
IPR013151 Immunoglobulin
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR11890 PTHR11890, 1 hit
PfamiView protein in Pfam
PF00047 ig, 1 hit
PF01582 TIR, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits
SM00255 TIR, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS50104 TIR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB1ASU0_MOUSE
AccessioniPrimary (citable) accession number: B1ASU0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: October 10, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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