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Protein

Tyrosine-protein kinase

Gene

Jak1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei907ATPUniRule annotation1
Active sitei1002Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi880 – 888ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1059683 Interleukin-6 signaling
R-MMU-110056 MAPK3 (ERK1) activation
R-MMU-112411 MAPK1 (ERK2) activation
R-MMU-1169408 ISG15 antiviral mechanism
R-MMU-1266695 Interleukin-7 signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6783783 Interleukin-10 signaling
R-MMU-6785807 Interleukin-4 and Interleukin-13 signaling
R-MMU-6788467 IL-6-type cytokine receptor ligand interactions
R-MMU-877300 Interferon gamma signaling
R-MMU-877312 Regulation of IFNG signaling
R-MMU-8854691 Interleukin-20 family signaling
R-MMU-8983432 Interleukin-15 signaling
R-MMU-8984722 Interleukin-35 Signalling
R-MMU-8985947 Interleukin-9 signaling
R-MMU-9020558 Interleukin-2 signaling
R-MMU-9020591 Interleukin-12 signaling
R-MMU-9020956 Interleukin-27 signaling
R-MMU-9020958 Interleukin-21 signaling
R-MMU-909733 Interferon alpha/beta signaling
R-MMU-912526 Interleukin receptor SHC signaling
R-MMU-912694 Regulation of IFNA signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:Jak1Imported
ORF Names:mCG_21706Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:96628 Jak1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSMUSG00000028530 Expressed in 307 organ(s), highest expression level in lymph node

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 420FERMInterPro annotationAdd BLAST387
Domaini439 – 528SH2InterPro annotationAdd BLAST90
Domaini582 – 854Protein kinaseInterPro annotationAdd BLAST273
Domaini874 – 1152Protein kinaseInterPro annotationAdd BLAST279

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili333 – 362Sequence analysisAdd BLAST30

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00900000140909
HOVERGENiHBG006195
KOiK11217
OMAiCFEKSEQ
OrthoDBiEOG091G01IS
TreeFamiTF327041

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016251 Tyr_kinase_non-rcpt_Jak/Tyk2
IPR020776 Tyr_kinase_non-rcpt_Jak1
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 2 hits
PIRSFiPIRSF000636 TyrPK_Jak, 1 hit
PRINTSiPR01823 JANUSKINASE
PR01824 JANUSKINASE1
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM00252 SH2, 1 hit
SM00219 TyrKc, 2 hits
SUPFAMiSSF47031 SSF47031, 1 hit
SSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50001 SH2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

B1ASP2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQYLNIKEDC NAMAFCAKMR SFKKTEVKQV VPEPGVEVTF YLLDREPLRL
60 70 80 90 100
GSGEYTAEEL CIRAAQECSI SPLCHNLFAL YDESTKLWYA PNRIITVDDK
110 120 130 140 150
TSLRLHYRMR FYFTNWHGTN DNEQSVWRHS PKKQKNGYEK KRVPEATPLL
160 170 180 190 200
DASSLEYLFA QGQYDLIKCL APIRDPKTEQ DGHDIENECL GMAVLAISHY
210 220 230 240 250
AMMKKMQLPE LPKDISYKRY IPETLNKSIR QRNLLTRMRI NNVFKDFLKE
260 270 280 290 300
FNNKTICDSS VSTHDLKVKY LATLETLTKH YGAEIFETSM LLISSENELS
310 320 330 340 350
RCHSNDSGNV LYEVMVTGNL GIQWRQKPNV VPVEKEKNKL KRKKLEYNKH
360 370 380 390 400
KKDDERNKLR EEWNNFSYFP EITHIVIKES VVSINKQDNK NMELKLSSRE
410 420 430 440 450
EALSFVSLVD GYFRLTADAH HYLCTDVAPP LIVHNIQNGC HGPICTEYAI
460 470 480 490 500
NKLRQEGSEE GMYVLRWSCT DFDNILMTVT CFEKSEVLGG QKQFKNFQIE
510 520 530 540 550
VQKGRYSLHG SMDHFPSLRD LMNHLKKQIL RTDNISFVLK RCCQPKPREI
560 570 580 590 600
SNLLVATKKA QEWQPVYSMS QLSFDRILKK DIIQGEHLGR GTRTHIYSGT
610 620 630 640 650
LLDYKDEEGI AEEKKIKVIL KVLDPSHRDI SLAFFEAASM MRQVSHKHIV
660 670 680 690 700
YLYGVCVRDV ENIMVEEFVE GGPLDLFMHR KSDALTTPWK FKVAKQLASA
710 720 730 740 750
LSYLEDKDLV HGNVCTKNLL LAREGIDSDI GPFIKLSDPG IPVSVLTRQE
760 770 780 790 800
CIERIPWIAP ECVEDSKNLS VAADKWSFGT TLWEICYNGE IPLKDKTLIE
810 820 830 840 850
KERFYESRCR PVTPSCKELA DLMTRCMNYD PNQRPFFRAI MRDINKLEEQ
860 870 880 890 900
NPDIVSEKQP TTEVDPTHFE KRFLKRIRDL GEGHFGKVEL CRYDPEGDNT
910 920 930 940 950
GEQVAVKSLK PESGGNHIAD LKKEIEILRN LYHENIVKYK GICMEDGGNG
960 970 980 990 1000
IKLIMEFLPS GSLKEYLPKN KNKINLKQQL KYAIQICKGM DYLGSRQYVH
1010 1020 1030 1040 1050
RDLAARNVLV ESEHQVKIGD FGLTKAIETD KEYYTVKDDR DSPVFWYAPE
1060 1070 1080 1090 1100
CLIQCKFYIA SDVWSFGVTL HELLTYCDSD FSPMALFLKM IGPTHGQMTV
1110 1120 1130 1140 1150
TRLVNTLKEG KRLPCPPNCP DEVYQLMRKC WEFQPSNRTT FQNLIEGFEA

LLK
Length:1,153
Mass (Da):133,353
Last modified:April 8, 2008 - v1
Checksum:i6E45E960303D66DC
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P52332JAK1_MOUSE
Tyrosine-protein kinase JAK1
Jak1
1,153Annotation score:
B1ASP3B1ASP3_MOUSE
Tyrosine-protein kinase JAK1
Jak1
18Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627251 Genomic DNA No translation available.
AL645668 Genomic DNA No translation available.
CH466527 Genomic DNA Translation: EDL30874.1
RefSeqiNP_666257.2, NM_146145.2
XP_006502875.1, XM_006502812.3
XP_011238753.1, XM_011240451.2
UniGeneiMm.289657

Genome annotation databases

EnsembliENSMUST00000102781; ENSMUSP00000099842; ENSMUSG00000028530
GeneIDi16451
KEGGimmu:16451
UCSCiuc008tvk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627251 Genomic DNA No translation available.
AL645668 Genomic DNA No translation available.
CH466527 Genomic DNA Translation: EDL30874.1
RefSeqiNP_666257.2, NM_146145.2
XP_006502875.1, XM_006502812.3
XP_011238753.1, XM_011240451.2
UniGeneiMm.289657

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102781; ENSMUSP00000099842; ENSMUSG00000028530
GeneIDi16451
KEGGimmu:16451
UCSCiuc008tvk.1 mouse

Organism-specific databases

CTDi3716
MGIiMGI:96628 Jak1

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00900000140909
HOVERGENiHBG006195
KOiK11217
OMAiCFEKSEQ
OrthoDBiEOG091G01IS
TreeFamiTF327041

Enzyme and pathway databases

ReactomeiR-MMU-1059683 Interleukin-6 signaling
R-MMU-110056 MAPK3 (ERK1) activation
R-MMU-112411 MAPK1 (ERK2) activation
R-MMU-1169408 ISG15 antiviral mechanism
R-MMU-1266695 Interleukin-7 signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6783783 Interleukin-10 signaling
R-MMU-6785807 Interleukin-4 and Interleukin-13 signaling
R-MMU-6788467 IL-6-type cytokine receptor ligand interactions
R-MMU-877300 Interferon gamma signaling
R-MMU-877312 Regulation of IFNG signaling
R-MMU-8854691 Interleukin-20 family signaling
R-MMU-8983432 Interleukin-15 signaling
R-MMU-8984722 Interleukin-35 Signalling
R-MMU-8985947 Interleukin-9 signaling
R-MMU-9020558 Interleukin-2 signaling
R-MMU-9020591 Interleukin-12 signaling
R-MMU-9020956 Interleukin-27 signaling
R-MMU-9020958 Interleukin-21 signaling
R-MMU-909733 Interferon alpha/beta signaling
R-MMU-912526 Interleukin receptor SHC signaling
R-MMU-912694 Regulation of IFNA signaling

Miscellaneous databases

ChiTaRSiJak1 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028530 Expressed in 307 organ(s), highest expression level in lymph node

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016251 Tyr_kinase_non-rcpt_Jak/Tyk2
IPR020776 Tyr_kinase_non-rcpt_Jak1
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 2 hits
PIRSFiPIRSF000636 TyrPK_Jak, 1 hit
PRINTSiPR01823 JANUSKINASE
PR01824 JANUSKINASE1
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM00252 SH2, 1 hit
SM00219 TyrKc, 2 hits
SUPFAMiSSF47031 SSF47031, 1 hit
SSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50001 SH2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB1ASP2_MOUSE
AccessioniPrimary (citable) accession number: B1ASP2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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