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Entry version 90 (02 Jun 2021)
Sequence version 3 (10 Feb 2021)
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Protein

SPOC domain-containing protein 1

Gene

Spocd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential excecutor of PIWIL4-piRNA pathway directed transposon DNA methylation and silencing in the male embryonic germ cells (PubMed:32674113).

Associates with the de novo DNA methylation machinery and repressive chromatin remodeling complexes (PubMed:32674113).

Tethering of PIWIL4 to a nascent transposable element transcript recruits repressive chromatin remodeling activities and the de novo methylation apparatus through SPOCD1 (PubMed:32674113).

Not required for piRNA biosynthesis (PubMed:32674113).

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, RNA-mediated gene silencing, Spermatogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SPOC domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Spocd1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3652045, Spocd1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Male mice are infertile with spermatozoa completely absent in the epididymis (PubMed:32674113). Male germ cells show derepression of transposable elements (TEs) and DNA hypomethylation of TEs (PubMed:32674113).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004519711 – 1015SPOC domain-containing protein 1Add BLAST1015

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B1ASB6

PRoteomics IDEntifications database

More...
PRIDEi
B1ASB6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
373430

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected in embryonic testis at embryonic days 14.5 (E14.5) and decreases by postnatal day 5.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000028784, Expressed in secondary oocyte and 46 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
B1ASB6, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DNMT3A, DNMT3C and DNMT3L.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000081284

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
B1ASB6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini410 – 530TFIIS centralPROSITE-ProRule annotationAdd BLAST121
Domaini688 – 791SPOCAdd BLAST104

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni73 – 97DisorderedSequence analysisAdd BLAST25
Regioni118 – 159DisorderedSequence analysisAdd BLAST42
Regioni213 – 320DisorderedSequence analysisAdd BLAST108
Regioni344 – 406DisorderedSequence analysisAdd BLAST63
Regioni643 – 685DisorderedSequence analysisAdd BLAST43
Regioni858 – 906DisorderedSequence analysisAdd BLAST49
Regioni967 – 1015DisorderedSequence analysisAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi286 – 320Basic and acidic residuesSequence analysisAdd BLAST35

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1634, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_029996_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B1ASB6

Identification of Orthologs from Complete Genome Data

More...
OMAi
ESLGGPC

TreeFam database of animal gene trees

More...
TreeFami
TF343963

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.472.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012921, SPOC_C
IPR003618, TFIIS_cen_dom
IPR036575, TFIIS_cen_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07744, SPOC, 1 hit
PF07500, TFIIS_M, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00510, TFS2M, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46942, SSF46942, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51321, TFIIS_CENTRAL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

B1ASB6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVDKFLARA GGQRTLSRFQ DSLCDFLATG SSRSLCGTSL DFPDRVLVCT
60 70 80 90 100
EGPAGMEEAS SPSFRQATTV EGMVSPEDPT LSKEGLSAKG PPPSPVLPPF
110 120 130 140 150
RRKCRKCGIC PQEEEKSGFS LRFGQRPDGD PPECASPEAF AGPPRLLSSK
160 170 180 190 200
DTEPGEPGGS WVECAVETEV ENMLFSKDGV APDSLDHLFE FPGLFGGEPL
210 220 230 240 250
SLVTQEPLQS PALYPEVLTE DSTDQQEVQP AFVVGSPGTP PDPVGPEDKA
260 270 280 290 300
QSGSRMELEQ GLSAPANSCA SSPEPLGGLD GAPLEQRRPT HVKKRPWTSP
310 320 330 340 350
DDSSQDHAEG ASKKDFPRLE ARVPRGVKTV YYVYTGSGIR LVGAASSSQP
360 370 380 390 400
GQIEPLEELD TNSARRKRRP TTAHPTPCQS DPSETENAEP HQQRAEDPGE
410 420 430 440 450
QGMTPLDAGV RSTVVRAMQE VLWTRAQELP DLALREDEVE AIAEGIEEAL
460 470 480 490 500
FHLTQDTNLR YKNKYRSLLF NLRDPRNVDL FLKVAHCDVT PNNLVQMSSI
510 520 530 540 550
QLAPKELSRW RDQEERKGLD IIEQQQKELY RLPASKLTHK GEVEIPRDLD
560 570 580 590 600
QMLTLEDLME PIVPRECSLQ PLSTPLEDTT NWHQHHQCDS NCQICTGGEE
610 620 630 640 650
GRKADDGSQP ELQVDISYNV DRKSSTKLPA FSGVIMNREE NAIQKAPGPA
660 670 680 690 700
PASSPEVLKV GETPPKEPQD RLQMPAGLKN APPSPPPWEG SLDMFSIKHF
710 720 730 740 750
RAKAQLISGH SCQLVQALPD VIRSAGRLPP SHVWDLLDSM GPSKAKDICV
760 770 780 790 800
IRLCPHGSRD IQNYRLLYSY LNNKQCHCLA TVQQVKMVLL PLPAFEPLPA
810 820 830 840 850
RLRPLGGPGL EITHTSLLLA VLFPKDALPD TATSIPVSNK VPKTVSFSKR
860 870 880 890 900
VERILYSPED RRSEATSSPL EEDPKQSLAR GSLAPRSVCA PQSFPRGRGR
910 920 930 940 950
QGPGWGQWSP EAAWCYSQHP SSAGPVFPGI GQGQHLHRAS CFHHDLLQHL
960 970 980 990 1000
KVLVTMSHQF QASLWPQSQD SLPPSTVVSA VPDPPGPSLG PMDGGGSNCP
1010
PPEGSDPLEP PEHEC
Length:1,015
Mass (Da):110,815
Last modified:February 10, 2021 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i12986EDA44CA9A89
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1ASB5B1ASB5_MOUSE
SPOC domain-containing protein 1
Spocd1
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7N9T6T7A0A7N9T6T7_MOUSE
SPOC domain-containing protein 1
Spocd1
936Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GL456106 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_017175994.1, XM_017320505.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
622480

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL456106 Genomic DNA No translation available.
RefSeqiXP_017175994.1, XM_017320505.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081284

Proteomic databases

PaxDbiB1ASB6
PRIDEiB1ASB6
ProteomicsDBi373430

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
31194, 25 antibodies

Genome annotation databases

GeneIDi622480

Organism-specific databases

MGIiMGI:3652045, Spocd1

Phylogenomic databases

eggNOGiKOG1634, Eukaryota
HOGENOMiCLU_029996_0_0_1
InParanoidiB1ASB6
OMAiESLGGPC
TreeFamiTF343963

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Spocd1, mouse
RNActiB1ASB6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000028784, Expressed in secondary oocyte and 46 other tissues
ExpressionAtlasiB1ASB6, baseline and differential

Family and domain databases

Gene3Di1.10.472.30, 1 hit
InterProiView protein in InterPro
IPR012921, SPOC_C
IPR003618, TFIIS_cen_dom
IPR036575, TFIIS_cen_dom_sf
PfamiView protein in Pfam
PF07744, SPOC, 1 hit
PF07500, TFIIS_M, 1 hit
SMARTiView protein in SMART
SM00510, TFS2M, 1 hit
SUPFAMiSSF46942, SSF46942, 1 hit
PROSITEiView protein in PROSITE
PS51321, TFIIS_CENTRAL, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPOC1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B1ASB6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2021
Last sequence update: February 10, 2021
Last modified: June 2, 2021
This is version 90 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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