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Protein

Glutamate receptor ionotropic, kainate 3

Gene

Grik3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei520GlutamateBy similarity1
Binding sitei525GlutamateBy similarity1
Binding sitei739GlutamateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-451308 Activation of Ca-permeable Kainate Receptor
R-MMU-500657 Presynaptic function of Kainate receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, kainate 3
Short name:
GluK3
Alternative name(s):
Glutamate receptor 7
Short name:
GluR-7
Short name:
GluR7
Gene namesi
Name:Grik3
Synonyms:Glur7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:95816 Grik3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 563ExtracellularBy similarityAdd BLAST532
Transmembranei564 – 584HelicalSequence analysisAdd BLAST21
Topological domaini585 – 636CytoplasmicSequence analysisAdd BLAST52
Transmembranei637 – 657HelicalSequence analysisAdd BLAST21
Topological domaini658 – 820ExtracellularSequence analysisAdd BLAST163
Transmembranei821 – 841HelicalSequence analysisAdd BLAST21
Topological domaini842 – 919CytoplasmicSequence analysisAdd BLAST78

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31By similarityAdd BLAST31
ChainiPRO_000041679332 – 919Glutamate receptor ionotropic, kainate 3Add BLAST888

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi76N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi99 ↔ 350By similarity
Glycosylationi278N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi381N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi415N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi426N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi548N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei869PhosphoserineBy similarity1
Cross-linki887Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiB1AS29
PaxDbiB1AS29
PeptideAtlasiB1AS29
PRIDEiB1AS29

PTM databases

iPTMnetiB1AS29
PhosphoSitePlusiB1AS29
SwissPalmiB1AS29

Expressioni

Tissue specificityi

Detected in whole brain, cerebellum, brain cortex and hippocampus.1 Publication

Gene expression databases

BgeeiENSMUSG00000001985 Expressed in 164 organ(s), highest expression level in median eminence of neurohypophysis
GenevisibleiB1AS29 MM

Interactioni

Subunit structurei

Homotetramer, and heterotetramer with either GRIK4 or GRIK5. Interacts with PRKCABP (By similarity). Interacts with NETO2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi200065, 3 interactors
IntActiB1AS29, 1 interactor
STRINGi10090.ENSMUSP00000030676

Structurei

3D structure databases

ProteinModelPortaliB1AS29
SMRiB1AS29
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni690 – 692Glutamate bindingBy similarity3

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1054 Eukaryota
ENOG410XPSH LUCA
GeneTreeiENSGT00910000143978
HOGENOMiHOG000234371
HOVERGENiHBG051839
InParanoidiB1AS29
KOiK05203
OMAiQVRWKHH
OrthoDBiEOG091G02LN
PhylomeDBiB1AS29
TreeFamiTF334668

Family and domain databases

InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR019594 Glu/Gly-bd
IPR001508 Iono_rcpt_met
IPR001320 Iontro_rcpt
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF01094 ANF_receptor, 1 hit
PF00060 Lig_chan, 1 hit
PF10613 Lig_chan-Glu_bd, 1 hit
PRINTSiPR00177 NMDARECEPTOR
SMARTiView protein in SMART
SM00918 Lig_chan-Glu_bd, 1 hit
SM00079 PBPe, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B1AS29-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAPWRRLRS LVWEYWAGFL VCAFWIPDSR GMPHVIRIGG IFEYADGPNA
60 70 80 90 100
QVMNAEEHAF RFSANIINRN RTLLPNTTLT YDIQRIHFHD SFEATKKACD
110 120 130 140 150
QLALGVVAIF GPSQGSCTNA VQSICNALEV PHIQLRWKHH PLDNKDTFYV
160 170 180 190 200
NLYPDYASLS HAILDLVQSL KWRSATVVYD DSTGLIRLQE LIMAPSRYNI
210 220 230 240 250
RLKIRQLPID SDDSRPLLKE MKRGREFRII FDCSHTMAAQ ILKQAMAMGM
260 270 280 290 300
MTEYYHFIFT TLDLYALDLE PYRYSGVNLT GFRILNVDNP HVSAIVEKWA
310 320 330 340 350
MERLQAAPRA ESGLLDGVMM TDAALLYDAV HIVSVCYQRA PQMTVNSLQC
360 370 380 390 400
HRHKAWRFGG RFMNFIKEAQ WEGLTGRIVF NKTSGLRTDF DLDIISLKED
410 420 430 440 450
GLEKVGVWSP ADGLNITEVA KGRGPNVTDS LTNRSLIVTT VLEEPFVMFR
460 470 480 490 500
KSDRTLYGND RFEGYCIDLL KELAHILGFS YEIRLVEDGK YGAQDDKGQW
510 520 530 540 550
NGMVKELIDH KADLAVAPLT ITHVREKAID FSKPFMTLGV SILYRKPNGT
560 570 580 590 600
NPSVFSFLNP LSPDIWMYVL LAYLGVSCVL FVIARFSPYE WYDAHPCNPG
610 620 630 640 650
SEVVENNFTL LNSFWFGMGS LMQQGSELMP KALSTRIIGG IWWFFTLIII
660 670 680 690 700
SSYTANLAAF LTVERMESPI DSADDLAKQT KIEYGAVKDG ATMTFFKKSK
710 720 730 740 750
ISTFEKMWAF MSSKPSALVK NNEEGIQRTL TADYALLMES TTIEYITQRN
760 770 780 790 800
CNLTQIGGLI DSKGYGIGTP MGSPYRDKIT IAILQLQEED KLHIMKEKWW
810 820 830 840 850
RGSGCPEEEN KEASALGIQK IGGIFIVLAA GLVLSVLVAV GEFIYKLRKT
860 870 880 890 900
AEREQRSFCS TVADEIRFSL TCQRRLKHKP QPPMMVKTDA VINMHTFNDR
910
RLPGKDSMSC STSLAPVFP
Length:919
Mass (Da):104,051
Last modified:April 8, 2008 - v1
Checksum:iDD543E45951ACB87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL607090, AL627328 Genomic DNA Translation: CAM19291.1
AL627328, AL607090 Genomic DNA Translation: CAM20078.1
BC118004 mRNA Translation: AAI18005.1
AF245444 mRNA Translation: AAF90049.1
CCDSiCCDS38878.1
RefSeqiNP_001074566.1, NM_001081097.2
UniGeneiMm.40896

Genome annotation databases

EnsembliENSMUST00000030676; ENSMUSP00000030676; ENSMUSG00000001985
GeneIDi14807
KEGGimmu:14807
UCSCiuc008usa.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL607090, AL627328 Genomic DNA Translation: CAM19291.1
AL627328, AL607090 Genomic DNA Translation: CAM20078.1
BC118004 mRNA Translation: AAI18005.1
AF245444 mRNA Translation: AAF90049.1
CCDSiCCDS38878.1
RefSeqiNP_001074566.1, NM_001081097.2
UniGeneiMm.40896

3D structure databases

ProteinModelPortaliB1AS29
SMRiB1AS29
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200065, 3 interactors
IntActiB1AS29, 1 interactor
STRINGi10090.ENSMUSP00000030676

PTM databases

iPTMnetiB1AS29
PhosphoSitePlusiB1AS29
SwissPalmiB1AS29

Proteomic databases

MaxQBiB1AS29
PaxDbiB1AS29
PeptideAtlasiB1AS29
PRIDEiB1AS29

Protocols and materials databases

DNASUi14807
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030676; ENSMUSP00000030676; ENSMUSG00000001985
GeneIDi14807
KEGGimmu:14807
UCSCiuc008usa.2 mouse

Organism-specific databases

CTDi2899
MGIiMGI:95816 Grik3

Phylogenomic databases

eggNOGiKOG1054 Eukaryota
ENOG410XPSH LUCA
GeneTreeiENSGT00910000143978
HOGENOMiHOG000234371
HOVERGENiHBG051839
InParanoidiB1AS29
KOiK05203
OMAiQVRWKHH
OrthoDBiEOG091G02LN
PhylomeDBiB1AS29
TreeFamiTF334668

Enzyme and pathway databases

ReactomeiR-MMU-451308 Activation of Ca-permeable Kainate Receptor
R-MMU-500657 Presynaptic function of Kainate receptors

Miscellaneous databases

ChiTaRSiGrik3 mouse
PROiPR:B1AS29
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001985 Expressed in 164 organ(s), highest expression level in median eminence of neurohypophysis
GenevisibleiB1AS29 MM

Family and domain databases

InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR019594 Glu/Gly-bd
IPR001508 Iono_rcpt_met
IPR001320 Iontro_rcpt
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF01094 ANF_receptor, 1 hit
PF00060 Lig_chan, 1 hit
PF10613 Lig_chan-Glu_bd, 1 hit
PRINTSiPR00177 NMDARECEPTOR
SMARTiView protein in SMART
SM00918 Lig_chan-Glu_bd, 1 hit
SM00079 PBPe, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGRIK3_MOUSE
AccessioniPrimary (citable) accession number: B1AS29
Secondary accession number(s): Q17R20, Q9JIA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: April 8, 2008
Last modified: November 7, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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