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Entry version 93 (26 Feb 2020)
Sequence version 1 (08 Apr 2008)
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Protein
Submitted name:

Microtubule-actin cross-linking factor 1

Gene

Macf1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi5555 – 5566PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi5591 – 5602PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalciumPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Microtubule-actin cross-linking factor 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Macf1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:108559 Macf1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonPROSITE-ProRule annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
B1ARU1

PeptideAtlas

More...
PeptideAtlasi
B1ARU1

PRoteomics IDEntifications database

More...
PRIDEi
B1ARU1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000028649 Expressed in lung and 317 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
B1ARU1 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B1ARU1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5542 – 5577EF-handInterPro annotationAdd BLAST36
Domaini5578 – 5613EF-handInterPro annotationAdd BLAST36
Domaini5618 – 5696GARInterPro annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni555 – 591DisorderedSequence analysisAdd BLAST37
Regioni1241 – 1276DisorderedSequence analysisAdd BLAST36
Regioni1386 – 1409DisorderedSequence analysisAdd BLAST24
Regioni1493 – 1530DisorderedSequence analysisAdd BLAST38
Regioni5449 – 5480DisorderedSequence analysisAdd BLAST32
Regioni5712 – 5895DisorderedSequence analysisAdd BLAST184

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1790 – 1817Sequence analysisAdd BLAST28
Coiled coili1841 – 1861Sequence analysisAdd BLAST21
Coiled coili2091 – 2118Sequence analysisAdd BLAST28
Coiled coili2244 – 2282Sequence analysisAdd BLAST39
Coiled coili2509 – 2536Sequence analysisAdd BLAST28
Coiled coili2543 – 2563Sequence analysisAdd BLAST21
Coiled coili2583 – 2610Sequence analysisAdd BLAST28
Coiled coili2621 – 2641Sequence analysisAdd BLAST21
Coiled coili2649 – 2676Sequence analysisAdd BLAST28
Coiled coili2689 – 2716Sequence analysisAdd BLAST28
Coiled coili2754 – 2774Sequence analysisAdd BLAST21
Coiled coili3019 – 3039Sequence analysisAdd BLAST21
Coiled coili3133 – 3153Sequence analysisAdd BLAST21
Coiled coili3226 – 3246Sequence analysisAdd BLAST21
Coiled coili3270 – 3290Sequence analysisAdd BLAST21
Coiled coili3377 – 3432Sequence analysisAdd BLAST56
Coiled coili3569 – 3589Sequence analysisAdd BLAST21
Coiled coili3595 – 3615Sequence analysisAdd BLAST21
Coiled coili4359 – 4379Sequence analysisAdd BLAST21
Coiled coili4592 – 4619Sequence analysisAdd BLAST28
Coiled coili5371 – 5391Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi576 – 590PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1245 – 1272PolyampholyteSequence analysisAdd BLAST28
Compositional biasi1514 – 1529PolyampholyteSequence analysisAdd BLAST16
Compositional biasi5731 – 5805PolarSequence analysisAdd BLAST75
Compositional biasi5842 – 5895PolarSequence analysisAdd BLAST54

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155824

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00051 EFh, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.920.20, 1 hit
3.90.1290.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029926 Dystonin-like
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR003108 GAR_dom
IPR036534 GAR_dom_sf
IPR035915 Plakin_repeat_sf
IPR001101 Plectin_repeat
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR23169:SF24 PTHR23169:SF24, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13499 EF-hand_7, 1 hit
PF02187 GAS2, 1 hit
PF00681 Plectin, 8 hits
PF00435 Spectrin, 18 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054 EFh, 2 hits
SM00243 GAS2, 1 hit
SM00250 PLEC, 18 hits
SM00150 SPEC, 30 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF143575 SSF143575, 1 hit
SSF47473 SSF47473, 1 hit
SSF75399 SSF75399, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
PS51460 GAR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 18 potential isoforms that are computationally mapped.Show allAlign All

B1ARU1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQKGLIDQDT GLVLLESQII MSGLIDPENS EKLSLEEGLT RNFINLPIYQ
60 70 80 90 100
QLLGLRDSLS LVSRLTGTLG SLSVVEAIEK KIISERLGLK VLEVHLATGG
110 120 130 140 150
FSLPPSENCI NLEEAFHQGF IASSLHSELQ SHLRSSKNLI DPNTAEKVGL
160 170 180 190 200
LDLMQRCIIH QESGLKLLPV KQLAGGMVSL KSGRKVSIFR AVQEGLIDRQ
210 220 230 240 250
VTVRLLEAQL FAGGIVDPRT GHRLTVEEAV RHNLIDQDMA CAILIRQLQT
260 270 280 290 300
GGIIDTVTGD RMTIDEAVTN NLVAAKIALV ILESLWSFMG LLLPESGEIL
310 320 330 340 350
PITDALEQGI VSTELAHKIL HNRQQIEALF LPTLTEIWSW EKATESGILD
360 370 380 390 400
KDLVNNLRSV CIPDMMPHIQ LADSAEQSKV GFAAGKPPVS GPREEGSSHG
410 420 430 440 450
EKLLFQLMTH SYIHAHTGQR LLLLDQELVE MLTSRDDCQV ILPEVFEIQH
460 470 480 490 500
QRLNTSEALQ ELYTGTISQI SSAKHPRKPC ESQFLSQNKD YPSQENCTEA
510 520 530 540 550
KGERSVVGIE CSPAESPERE LFLKEQEAII ENVGSLKVIN KVKLKLQRPL
560 570 580 590 600
LGSRKEEQAE TLREENISGD PLLVECPEES EGKDLSTEKS KCQTPTKCSF
610 620 630 640 650
TCHKEQVKTI KDIPSETGTS LIKSQNQMSQ FQVDTSVGLR SEFKSEHDMN
660 670 680 690 700
VNSLEKELKE ELLVKDGHKQ SQEGQSVADG QTVALEKTDT EDNADEPALL
710 720 730 740 750
HSSPFEDATL STLSAQLQDG GIFNEETGQK LLLNEAIAQG LVSSHTAVKL
760 770 780 790 800
MGKLNMFRGF FDSQTCESLT TEEVIDEGLM DEKLLYNVLM SDKAISGILD
810 820 830 840 850
PRTHSLCSVK EAVAAGLLDK ETATRILEGQ VITGGIVDLK RGKKLSVTLA
860 870 880 890 900
SNLGLVDTAD QTELINLEKA TKGRGAEKAV KERLIELQME TAGLMDPESK
910 920 930 940 950
APLTVLQSID RGILEREAAV YLLTKQVLDG GIIHHISGLR LSVDNAFKHG
960 970 980 990 1000
LIGEDMARQL RKVENFIHYQ FFHPQTKEAL SFSEAIKLDL VSPDLKREIQ
1010 1020 1030 1040 1050
EIQDFSGNLG DFIYGQKLTL AKTNKEESLA NKTELPSGVM HGVIDPENCT
1060 1070 1080 1090 1100
IIPYSELVKK CRIDTESGWR YLEVIPFSDI KDEAGNNVLT PPEAIQLGKV
1110 1120 1130 1140 1150
DFASALKVLE AQANTGGIID MATGKRVTLA SALEKKLLDE NMARIIASHQ
1160 1170 1180 1190 1200
MLSGGIIDIY SDQRVTLNDA VEKRLISPEL AAMIQVDPLA EQGGTGVCEL
1210 1220 1230 1240 1250
KGDFLRKELL SESSKTPRES YSKEKHEAVL QAGSLCAPEK AGIRGSNGEK
1260 1270 1280 1290 1300
AEKGRKISVE MEGQRQDEKA SSDNKVSASI LSPFGFEGES SYQVSVTHPC
1310 1320 1330 1340 1350
SESCDLKPRE ETRSCMKKCA VVERDKVVTQ IKMVSHVKQS TSGLDAEEAR
1360 1370 1380 1390 1400
ERQGRMVSKE QGSHYETAGN LLSERSVRVD RRVRREMGGE QSVQMSREAA
1410 1420 1430 1440 1450
VLSEEELDQE VTIGDEPDSF VKSQSMKMIG NDKGKEAGIE KDISVVCKIE
1460 1470 1480 1490 1500
GFPSQMTSKD ASLTNQDALP FYTEGETKTV NLCSILKPGE KLSQETASTV
1510 1520 1530 1540 1550
QKEPLSSEIP RPERLNSQES DEEPQISDVP HISKGDMAAQ ITTRQETTDV
1560 1570 1580 1590 1600
QDLYITSKSS ETKDKIFPSK NYIEKLHQEI PMDPTRSHKL KEATISTLET
1610 1620 1630 1640 1650
EGISYLDSSD IKSLCEDSKA DHKSCGHQKS KVTTTQAKKS LEVVDLLVRD
1660 1670 1680 1690 1700
TEEGSSEDRV GQRGPRVLAS LLPEKLPTRT VQSENIRQHD AVIPAISEIR
1710 1720 1730 1740 1750
EEMALSLPCS VVKVDGKIPK EKHKEILGDE QGPFMAIPSG KGIEGVNPEP
1760 1770 1780 1790 1800
CRATQNVFTR RLCLEHDEKL VSYLSLLRDI EMRTKQIQPL ELNVAELQDL
1810 1820 1830 1840 1850
LGQAKELDRE LKDLSTVVSQ ELECVDRIVI SQPQEVPAQL LKALEKDAKN
1860 1870 1880 1890 1900
LQKSLDSVSD SWSSRFLHLQ SAVEVKKATV LNRHKELQGK LQDLRAWVGR
1910 1920 1930 1940 1950
ASLTLNSKGC DTETDADSLS HTLQPYKDMK QSMAERKSQL DALALDIQLF
1960 1970 1980 1990 2000
ISEHPQDLSL QQNQEMLQFL SELQRSFQGL VEHTAAQKDV VQGHLQQVQQ
2010 2020 2030 2040 2050
EVQVKTLQKQ QDTCHKKLED LCNWVGQAER ALERHQGGAS RQELPALQQN
2060 2070 2080 2090 2100
QSDLKDLQGD IQSHSTSFAT AVKDIEGFLE ENQTKLSPQE LTALREKLHQ
2110 2120 2130 2140 2150
AKEQYEVLQE RTRVAQKELE EAVTSALQQE TEKSKAATEL AENKRKIDAL
2160 2170 2180 2190 2200
LDWVASVGSS ERKPQASLPG MEQFSGACLE KQTLAATDGH VDVNQVPETL
2210 2220 2230 2240 2250
DRQYELMKAR HQELLSQQQN FIVATQSVQS FLDQHSHNLT PEERQKLQEK
2260 2270 2280 2290 2300
LGELKEQYAA SLARSEAELK QTQALRDELQ KFLQDHKEFE NWLQQSENEL
2310 2320 2330 2340 2350
DSMHKGGSSP EALNSLLKRQ GSFSEDVISH KGDLRFVTIS GQKVLETENN
2360 2370 2380 2390 2400
FEEGQEPSAT RNLVNEKLKD ATERYTTLHS KCIRLGSHLS MLLGQYQQFQ
2410 2420 2430 2440 2450
SSADSLQAWV LTCEASVGKL LSDTVASDPG VLQQQLATTK QLQEELAEHQ
2460 2470 2480 2490 2500
VPVEKLQKAA HDLLDIEGEP ALDCRPIQET TDSISSRFQN LSCSLDERSA
2510 2520 2530 2540 2550
LLQKAIAQSQ SVQESMESLL QSIREVEQNL ERDQVASLSS GVIQEALANN
2560 2570 2580 2590 2600
MKLKQDIARQ KSSLEATHDM VTRFMETADS NSASVLQGKL AELSQRFQQL
2610 2620 2630 2640 2650
QLQQQEKESN LKKLLPQAEM FEQLSNKLQQ FMENKSRLLA SGNQPDQDIA
2660 2670 2680 2690 2700
HFSQQIQELT LAMEDQKENL DTLEHLVTTL GSCGFALDLS QHQDKIQNLK
2710 2720 2730 2740 2750
KDFTELQKTV QEREKDASTC QEQLDEFRKL IRTFQKWLKE TEGNVPPAKT
2760 2770 2780 2790 2800
FVSAKELEKQ IEHLKDLISD WESKGALLGE INAKGTALES LIMDITAPDS
2810 2820 2830 2840 2850
QAKTGSILPP VGSSVGSVNG YHTCKDLTEI QCDMFDVNSK YEKLWEVLRE
2860 2870 2880 2890 2900
RQESLQTVFS RMEEVQKEAS SVLQWLESKE EVLKAMDATL SPTKTETVKA
2910 2920 2930 2940 2950
QAESNKAFLA ELEQNSPKIQ KVKEALAGLL KTYPNSQEAE NWKKMQEDLN
2960 2970 2980 2990 3000
SRWEKATEVT VARQKQLEES ASHLACFQAA ESQLRPWLME KELMMGVLGP
3010 3020 3030 3040 3050
LSIDPNMLNA QKQQVQFMLK EFEARRQQHE QLNEAAQGIL TGPGDMSPSA
3060 3070 3080 3090 3100
SQVHKDLQSI SQKWVELTDK LNSRSSQIDQ AIVKSTQYQD LLQDLSEKVK
3110 3120 3130 3140 3150
AIGQRLSGQS AISTQPEAVK QQLEETSEIR SDLGQLDNEI KEAQTLCQEL
3160 3170 3180 3190 3200
SLLIGEQYLK DELKKRLETV ALPLQGLEDL AADRMNRLQA ALASTQQFQQ
3210 3220 3230 3240 3250
MFDELRTWLD EKQSQQAKNC PISAKLERLQ CQLQENEEFQ KNLNQHSGSY
3260 3270 3280 3290 3300
EVIVAEGEAL LLSVPPGEEK KTLQNQLVEL RSHWEDLSKK TANRQSRLKD
3310 3320 3330 3340 3350
CMQKAQKYQG HVEDLVPWID ECKSKMSELQ VTLDPVQLES SLLRSKAMLN
3360 3370 3380 3390 3400
EAEKRRSLLE ILNSAADILI NSSEIDEDEI RDEKAGLNQN MDAITEELQA
3410 3420 3430 3440 3450
KTSSLEEMTQ RLKEFQESFK NIEKKVEGAK HQLEIFDALG SQACSNKNLE
3460 3470 3480 3490 3500
KLKAQQEVLQ ALEPQVDYLR NFTQGLVEDA PDGSDASPLV HQAEVAQQEF
3510 3520 3530 3540 3550
LEVKQRVSSS CLTMENKLEG IGQFHCRVRE MFSQLADLDD ELDGMGAIGR
3560 3570 3580 3590 3600
DTDSLQSQIE DVRLFLNKIQ ALRFDIEDSE AECRKMLEEE GTLDLLGLKR
3610 3620 3630 3640 3650
ELEALNKQCG KLTERGKVRQ EQLELTLGRV EDFYRKLKAL NDAATAAEEG
3660 3670 3680 3690 3700
EALQWIVGTE VDVINQQLAD FKLFQKDQVD PLQVKLQQVN GLGQGLIQSA
3710 3720 3730 3740 3750
GKNCDVQGLE HDMDEINTRW NTLNKKVAQR IAQLQEALLH CGKFQDALEP
3760 3770 3780 3790 3800
LLSWLTDTEE LIANQKPPSA EYKVVKAQIQ EQKLLQRLLD DRKATVDMLQ
3810 3820 3830 3840 3850
AEGGRIAQSA ELADREKITG QLESLERRWT DLLSKAAARQ KQLEDILVLA
3860 3870 3880 3890 3900
KQFHETAEPI SDFLSVTEKK LANSEPVGTQ TAKIHQQIIR HKALEEEIEN
3910 3920 3930 3940 3950
HATDVHQAVK IGQSLSSLTC PAEQGIMSEK LDSLQARYSE IQDRCCRKAS
3960 3970 3980 3990 4000
LLEQALFNAR LFGEDEVEVL NWLAEVEDKL STVFVKDYRQ DVLQKQHADH
4010 4020 4030 4040 4050
LALNEEIINR KKNVDQAIKN GQALLKQTTG EEVLLIQEKL DGIKTRYADI
4060 4070 4080 4090 4100
TLTSSKALRT LEQARQLATK FHSTYEELTG WLREAEEELA ASGGQSPTGE
4110 4120 4130 4140 4150
QIPQFQQRQK ELKKEVMEHR LVLDTVNEVS HALLELVPWR AREGLDKLVS
4160 4170 4180 4190 4200
DANEQYKLIS DTVGQRVDEI DAAIQRSQQY EQAADAELAW VAETKRKLMA
4210 4220 4230 4240 4250
LGPIRLEQDQ TTAQLQVQKA FSIDIIRHKD SMDELFSHRG EIFSTCGEEQ
4260 4270 4280 4290 4300
KAVLQEKTEC LIQQYEAVSL LNSERYARLE RAQVLVNQFW ETYEELSPWA
4310 4320 4330 4340 4350
EETLALIAQL PPPAVDHEQL RQQQEEMRQL RESIAEHKPH IDKILKIGPQ
4360 4370 4380 4390 4400
LKELNPEEGK MVEEKYQKAE NMYAQIKDEV RQRALALDEA VSQSAQFHDK
4410 4420 4430 4440 4450
IEPMLETLEN LSSRLRMPPL IPAEVDKIRE CISDNKSATV ELEKLQPSFE
4460 4470 4480 4490 4500
ALKRRGEELI GRSQGADKDL AAKEIQDKLD QMVFFWEDIK ARSEEREIKF
4510 4520 4530 4540 4550
LDVLELAEKF WYDMAALLTT IKDTQDIVHD LESPGIDPSI IKQQVEAAET
4560 4570 4580 4590 4600
IKEETDGLHE ELEFIRILGA DLIFACGETE KPEVKKSIDE MNNAWENLNK
4610 4620 4630 4640 4650
TWKERLEKLE DAMQAAVQYQ DTLQAMFDWL DNTVIKLCTM PPVGTDLNTV
4660 4670 4680 4690 4700
KDQLNEMKEF KVEVYQQQIE MEKLNHQGEL MLKKATDETD RDIIREPLTE
4710 4720 4730 4740 4750
LKHLWENLGE KIAHRQHKLE GALLALGQFQ HALEELMSWL THTEELLDAQ
4760 4770 4780 4790 4800
RPISGDPKVI EVELAKHHVL KNDVLAHQAT VATVNKAGSE LLESSAGDDA
4810 4820 4830 4840 4850
SSLRSRLETM NQCWESVLQK TEEREQQLQS TLQQAQGFHS EIEDFLLELN
4860 4870 4880 4890 4900
RMENQLSASK PTGGLPETAR EQLDTHMELH SQLRAKEEIY NQLLDKGRLM
4910 4920 4930 4940 4950
LLSRGDSGSG SKTEQSVALL EQKWHAVSSK VEERKSKLEE ALSLATEFQN
4960 4970 4980 4990 5000
SLQEFINWLT LAEQSLNIAS PPSLILNTVL SQIEEHKVFA NEVNDHRDQI
5010 5020 5030 5040 5050
IELDQTGNQL KFLSQKQDVV LIKNLLVSVQ SRWEKVVQRS IERGRSLDDA
5060 5070 5080 5090 5100
RKRAKQFHEA WKKLIDWLED AESHLDSELE ISNDPDKIKL QLSKHKEFQK
5110 5120 5130 5140 5150
TLGGKQPVYD TTIRTGRALK EKTLLAGDTQ KLDNLLGEVR DKWDTVCGKS
5160 5170 5180 5190 5200
VERQHKLEEA LLFSGQFMDA LQALVDWLYK VEPQLAEDQP VHGDLDLVMN
5210 5220 5230 5240 5250
LMDAHKVFQK ELGKRTGTVQ VLKRSGRELI EGSRDDTTWV KGQLQELSTR
5260 5270 5280 5290 5300
WDTVCKLSVS KQSRLEQALK QAEEFRDTVH MLLEWLSEAE QTLRFRGALP
5310 5320 5330 5340 5350
DDTEALQSLI DTHKEFMKKV EEKRVDVNTA VAMGEAILAV CHPDCITTIK
5360 5370 5380 5390 5400
HWITIIRARF EEVLTWAKQH QQRLETALSE LVANAELLEE LLAWIQWAET
5410 5420 5430 5440 5450
TLIQRDQEPI PQNIDRVKAL ITEHQSFMEE MTRKQPDVDR VTKTYKRKSV
5460 5470 5480 5490 5500
EPTHAPFMEK SRSGSRKSLN QPTPPPMPIL SQSEAKNPRI NQLSARWQQV
5510 5520 5530 5540 5550
WLLALERQRK LNDALDRLEE LKEFANFDFD VWRKKYMRWM NHKKSRVMDF
5560 5570 5580 5590 5600
FRRIDKDQDG KITRQEFIDG ILASKFPTTK LEMTAVADIF DRDGDGYIDY
5610 5620 5630 5640 5650
YEFVAALHPN KDAYRPTTDA DKIEDEVTRQ VAQCKCAKRF QVEQIGENKY
5660 5670 5680 5690 5700
RFFLGNQFGD SQQLRLVRIL RSTVMVRVGG GWMALDEFLV KNDPCRARGR
5710 5720 5730 5740 5750
TNIELREKFI LPEGASQGMT PFRSRGRRSK PSSRAASPTR SSSSASQSNH
5760 5770 5780 5790 5800
SCTSMPSSPA TPASGTKVIS SSGSKLKRPT PAFHSSRTSL AGDTSNSSSP
5810 5820 5830 5840 5850
ASTGAKANRA DPKKSASRPG SRAGSRAGSR ASSRRGSDAS DFDLLETQSA
5860 5870 5880 5890
CSDTSESSAA GGQGSSRRGL TKPSKIPTMS KKTTTASPRT PGPKR
Length:5,895
Mass (Da):663,284
Last modified:April 8, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD274C06A367F9678
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 18 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9QXZ0MACF1_MOUSE
Microtubule-actin cross-linking fac...
Macf1 Acf7, Aclp7, Macf
7,354Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PVY8E9PVY8_MOUSE
Microtubule-actin cross-linking fac...
Macf1
7,355Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MQA6A0A0A0MQA6_MOUSE
Microtubule-actin cross-linking fac...
Macf1
5,328Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1ARU4B1ARU4_MOUSE
Microtubule-actin cross-linking fac...
Macf1
7,353Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7ACR9F7ACR9_MOUSE
Microtubule-actin cross-linking fac...
Macf1
5,333Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QA63E9QA63_MOUSE
Microtubule-actin cross-linking fac...
Macf1
7,351Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QNP1E9QNP1_MOUSE
Microtubule-actin cross-linking fac...
Macf1
5,478Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6Q750F6Q750_MOUSE
Microtubule-actin cross-linking fac...
Macf1
4,429Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6YKN8F6YKN8_MOUSE
Microtubule-actin cross-linking fac...
Macf1
544Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6RCJ3F6RCJ3_MOUSE
Microtubule-actin cross-linking fac...
Macf1
452Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL606918 Genomic DNA No translation available.
AL606932 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000106213; ENSMUSP00000101819; ENSMUSG00000028649

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606918 Genomic DNA No translation available.
AL606932 Genomic DNA No translation available.

3D structure databases

SMRiB1ARU1
ModBaseiSearch...

Proteomic databases

MaxQBiB1ARU1
PeptideAtlasiB1ARU1
PRIDEiB1ARU1

Genome annotation databases

EnsembliENSMUST00000106213; ENSMUSP00000101819; ENSMUSG00000028649

Organism-specific databases

MGIiMGI:108559 Macf1

Phylogenomic databases

GeneTreeiENSGT00940000155824

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Macf1 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000028649 Expressed in lung and 317 other tissues
ExpressionAtlasiB1ARU1 baseline and differential

Family and domain databases

CDDicd00051 EFh, 1 hit
Gene3Di3.30.920.20, 1 hit
3.90.1290.10, 6 hits
InterProiView protein in InterPro
IPR029926 Dystonin-like
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR003108 GAR_dom
IPR036534 GAR_dom_sf
IPR035915 Plakin_repeat_sf
IPR001101 Plectin_repeat
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
PANTHERiPTHR23169:SF24 PTHR23169:SF24, 2 hits
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF02187 GAS2, 1 hit
PF00681 Plectin, 8 hits
PF00435 Spectrin, 18 hits
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SM00243 GAS2, 1 hit
SM00250 PLEC, 18 hits
SM00150 SPEC, 30 hits
SUPFAMiSSF143575 SSF143575, 1 hit
SSF47473 SSF47473, 1 hit
SSF75399 SSF75399, 6 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
PS51460 GAR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB1ARU1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B1ARU1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: February 26, 2020
This is version 93 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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