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Protein
Submitted name:

Potassium voltage-gated channel, subfamily H (eag-related), member 6

Gene

Kcnh6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channelSAAS annotation, Voltage-gated channelSAAS annotation
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-MMU-1296072 Voltage gated Potassium channels

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium voltage-gated channel, subfamily H (eag-related), member 6Imported
Gene namesi
Name:Kcnh6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2684139 Kcnh6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei261 – 282HelicalSequence analysisAdd BLAST22
Transmembranei398 – 426HelicalSequence analysisAdd BLAST29
Transmembranei438 – 462HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiB1AR82

Expressioni

Gene expression databases

BgeeiENSMUSG00000001901 Expressed in 38 organ(s), highest expression level in pons
ExpressionAtlasiB1AR82 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliB1AR82
SMRiB1AR82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini541 – 641Cyclic nucleotide-bindingInterPro annotationAdd BLAST101

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili735 – 755Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00900000140833
HOGENOMiHOG000230793
HOVERGENiHBG052232

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
cd00130 PAS, 1 hit
Gene3Di1.20.120.350, 1 hit
2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR005821 Ion_trans_dom
IPR003938 K_chnl_volt-dep_EAG/ELK/ERG
IPR030172 KCNH6
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR014710 RmlC-like_jellyroll
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10217:SF468 PTHR10217:SF468, 3 hits
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF00520 Ion_trans, 1 hit
PF13426 PAS_9, 1 hit
PRINTSiPR01463 EAGCHANLFMLY
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit
SSF55785 SSF55785, 1 hit
TIGRFAMsiTIGR00229 sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

B1AR82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVRRGHVAP QNTYLDTIIR KFEGQSRKFL IANAQMENCA IIYCNDGFCE
60 70 80 90 100
LFGYSRVEVM QRPCTCDFLT GPNTPSSAVS RLAQALLGAE ECKVDILYYR
110 120 130 140 150
KDASSFRCLV DVVPVKNEDG AVIMFILNFE DLAQLLAKSS SRSLTQRLLS
160 170 180 190 200
HSFLGSEGSH SRPSGQGPGP GRGKYGTVSQ IPQFTLSFVE FNLEKHRSGS
210 220 230 240 250
TTEIEIIAPH KVVERTQNVT EKVTQVLSLG ADVLPEYKLQ APRIHRGTIL
260 270 280 290 300
HYSPFKAVWD WLILLLVIYT AVFTPYSAAF LLSDQDDSQR GTCGYTCSPL
310 320 330 340 350
TVVDLIVDIM FVVDIVINFR TTYVNTNDEV VSHPRRIAVH YFKGWFLIDM
360 370 380 390 400
VAAIPFDLLI FRTGSDETTT LIGLLKTARL LRLVRVARKL DRYSEYGAAV
410 420 430 440 450
LFLLMCTFAL IAHWLACICS LTSVGFGNVS PNTNSEKVFS ICVMLIGSLM
460 470 480 490 500
YASIFGNVSA IIQRLYSGTA RYHTQMLRVK EFIRFHQIPN PLRQRLEEYF
510 520 530 540 550
QHAWSYTNGI DMNAVLKGFP ECLQADICLH LHRALLQHCP AFRGASKGCL
560 570 580 590 600
RALAVKFKTT HAPPGDTLVH LGDVLSTLYF ISRGSIEILR DDVVVAILGK
610 620 630 640 650
NDIFGEPASL HARPGKSSAD VRALTYCDLH KIHRADLLEV LDMYPAFADT
660 670 680 690 700
FWNKLEVTFN LRDADGGLHS TPRQAPGNQD PQGFFLNDSQ SGAAPSLSIS
710 720 730 740 750
DTSGLWPELL QQMPPSPPNP REKLDCWPRE LGFKLEQLQA QMNRLESRVS
760 770 780 790 800
SDLSRILQLL QHPQGHPGYI LGAPASSDLA LFPETSVTQS SESMLLVGHL
810 820 830 840 850
PSAQTLSYGD LDKHIRMPRN FSPRIPHVAA AMDKSLVPSS EQEQPKGLLS
860 870 880 890
PLASPLCPLE VQGLGGPHFS SLPEHLSSVP KQLEFQRHGS DPGFTRS
Length:897
Mass (Da):99,676
Last modified:April 8, 2008 - v1
Checksum:iB2E9348B771FC0F6
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q32ME0Q32ME0_MOUSE
potassium Voltage-gated channel, su...
Kcnh6 mCG_141098
950Annotation score:
M0QW64M0QW64_MOUSE
Potassium voltage-gated channel, su...
Kcnh6
775Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596331 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000106903; ENSMUSP00000102516; ENSMUSG00000001901

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596331 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliB1AR82
SMRiB1AR82
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiB1AR82

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106903; ENSMUSP00000102516; ENSMUSG00000001901

Organism-specific databases

MGIiMGI:2684139 Kcnh6

Phylogenomic databases

GeneTreeiENSGT00900000140833
HOGENOMiHOG000230793
HOVERGENiHBG052232

Enzyme and pathway databases

ReactomeiR-MMU-1296072 Voltage gated Potassium channels

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001901 Expressed in 38 organ(s), highest expression level in pons
ExpressionAtlasiB1AR82 baseline and differential

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
cd00130 PAS, 1 hit
Gene3Di1.20.120.350, 1 hit
2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR005821 Ion_trans_dom
IPR003938 K_chnl_volt-dep_EAG/ELK/ERG
IPR030172 KCNH6
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR014710 RmlC-like_jellyroll
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10217:SF468 PTHR10217:SF468, 3 hits
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF00520 Ion_trans, 1 hit
PF13426 PAS_9, 1 hit
PRINTSiPR01463 EAGCHANLFMLY
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit
SSF55785 SSF55785, 1 hit
TIGRFAMsiTIGR00229 sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB1AR82_MOUSE
AccessioniPrimary (citable) accession number: B1AR82
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: November 7, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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