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UniProtKB - B1AR69 (B1AR69_MOUSE)
Protein
Submitted name:
Myosin, heavy polypeptide 13, skeletal muscle
Gene
Myh13
Organism
Mus musculus (Mouse)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 179 – 186 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- actin filament binding Source: InterPro
- ATP binding Source: UniProtKB-UniRule
- cytoskeletal motor activity Source: UniProtKB-UniRule
GO - Biological processi
- cellular response to starvation Source: MGI
Keywordsi
Molecular function | Actin-bindingPROSITE-ProRule annotationARBA annotation, Motor protein, Muscle protein, MyosinPROSITE-ProRule annotationARBA annotation |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: Myosin, heavy polypeptide 13, skeletal muscleImported |
Gene namesi | Name:Myh13Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1339967, Myh13 |
VEuPathDBi | HostDB:ENSMUSG00000060180 |
Subcellular locationi
Cytoskeleton
- myosin complex Source: UniProtKB-KW
Other locations
- myofibril Source: MGI
- myosin filament Source: UniProtKB-KW
Keywords - Cellular componenti
Thick filamentARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000060180, Expressed in skeletal muscle tissue and 51 other tissues |
Interactioni
GO - Molecular functioni
- actin filament binding Source: InterPro
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000104324 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 82 | Myosin N-terminal SH3-likeInterPro annotationAdd BLAST | 50 | |
Domaini | 86 – 782 | Myosin motorInterPro annotationAdd BLAST | 697 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 659 – 681 | Actin-bindingPROSITE-ProRule annotationAdd BLAST | 23 | |
Regioni | 1397 – 1419 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 1909 – 1938 | DisorderedSequence analysisAdd BLAST | 30 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 846 – 1160 | Sequence analysisAdd BLAST | 315 | |
Coiled coili | 1168 – 1188 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 1197 – 1238 | Sequence analysisAdd BLAST | 42 | |
Coiled coili | 1246 – 1266 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 1274 – 1336 | Sequence analysisAdd BLAST | 63 | |
Coiled coili | 1344 – 1378 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 1457 – 1600 | Sequence analysisAdd BLAST | 144 | |
Coiled coili | 1612 – 1646 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 1654 – 1709 | Sequence analysisAdd BLAST | 56 | |
Coiled coili | 1724 – 1807 | Sequence analysisAdd BLAST | 84 | |
Coiled coili | 1809 – 1836 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1404 – 1419 | Polar residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.PROSITE-ProRule annotationARBA annotation
Keywords - Domaini
Coiled coilSequence analysisARBA annotationPhylogenomic databases
eggNOGi | KOG0161, Eukaryota |
GeneTreei | ENSGT00940000162543 |
HOGENOMi | CLU_000192_8_1_1 |
OMAi | MDYENDP |
OrthoDBi | 47111at2759 |
TreeFami | TF314375 |
Family and domain databases
CDDi | cd14923, MYSc_Myh13, 1 hit |
Gene3Di | 1.20.5.370, 4 hits 2.30.30.360, 1 hit 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR042702, Myh13_MYSc IPR001609, Myosin_head_motor_dom IPR004009, Myosin_N IPR008989, Myosin_S1_N IPR002928, Myosin_tail IPR027417, P-loop_NTPase IPR014751, XRCC4-like_C |
Pfami | View protein in Pfam PF00063, Myosin_head, 1 hit PF02736, Myosin_N, 1 hit PF01576, Myosin_tail_1, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM00242, MYSc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit PS51456, MYOSIN_MOTOR, 1 hit PS51844, SH3_LIKE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
B1AR69-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSDAEMAIF GEAAPYLRKP EKERIEAQNR PFDSKKACFA VDDKEMYVKG
60 70 80 90 100
MIQSRENDKV IVKTLDDREL TLNSDQVFPM NPPKFDKIED MAMMTHLHEP
110 120 130 140 150
AVLYNLKERY AAWMIYTYSG LFCVTVNPYK WLPVYNPEVV AAYRGKKRQE
160 170 180 190 200
APPHIFSISD NAYQFMLTDR DNQSILITGE SGAGKTVNTK RVIQYFATIA
210 220 230 240 250
VTGDKKKEQQ PGKMQGTLED QIIQANPLLE AFGNAKTVRN DNSSRFGKFI
260 270 280 290 300
RIHFGATGKL ASADIETYLL EKSRVTFQLS SERSYHIFYQ IMSNKKPELI
310 320 330 340 350
DLLLISTNPF DFPFVSQGEV TVASIDDSEE LLATDNAIDI LGFSPEEKVG
360 370 380 390 400
IYKLTGAVMH YGNMKFKQKQ REEQAEPDGT EVADKAGYLM GLNSAEMLKG
410 420 430 440 450
LCCPRVKVGN EYVTKGQNVQ QVTNSVGALA KAVYEKMFLW MVTRINQQLD
460 470 480 490 500
TKQPRQYFIG VLDIAGFEIF DFNSLEQLCI NFTNEKLQQF FNHHMFVLEQ
510 520 530 540 550
EEYKKEGIEW EFIDFGMDLA ACIELIEKPM GIFSILEEEC MFPKATDTSF
560 570 580 590 600
KNKLYDQHLG KSNNFQKPKP TKGKAEAHFS LVHYAGTVDY NIAGWLDKNK
610 620 630 640 650
DPLNETVVGL YQKSSLKLLS FLFSNYAGAE AGDSAGGKKG GKKKGSSFQT
660 670 680 690 700
VSAVFRENLN KLMTNLRSTH PHFVRCLIPN ETKTPGVMDH YLVMHQLRCN
710 720 730 740 750
GVLEGIRICR KGFPSRILYA DFKQRYRILN ASAIPEGQFI DSKNASEKLL
760 770 780 790 800
NSIDVDREQF RFGHTKVFFK AGLLGLLEEM RDEKLVTLMT RTQAVCRGYL
810 820 830 840 850
MRVEFKKMME RRESIFCIQY NVRSFMNVKH WPWMNLFFKI KPLLKSAEAE
860 870 880 890 900
KEMATMKEDF ERAKEDLARS EARRKELEEK MVSLLQEKND LQLQVQSETE
910 920 930 940 950
NLMDAEERCE GLIKSKIQLE AKVKELNERL EEEEEMNSEL VAKKRNLEDK
960 970 980 990 1000
CSSLKRDIDD LELTLTKVEK EKHATENKVK NLSEEMTALE ETISKLTKEK
1010 1020 1030 1040 1050
KSLQEAHQQT LDDLQVEEDK VNGLIKINVK LEQQTDDLEG SLEQEKKLRA
1060 1070 1080 1090 1100
DLERVKRKLE GDLKMSQESI MDLENDTQQL EEKLKKKEFE MSQLQTRIDD
1110 1120 1130 1140 1150
EQVLSLQLQK KIKELQARTE ELEEEIEAEH TVRAKIEKQR SDLARELEEI
1160 1170 1180 1190 1200
SERLEEASGA TSAQIEMNKK RESEFQKLRR DLEEATLQHE ATAATLRKKH
1210 1220 1230 1240 1250
ADTVAELGEQ IDNLQRVKQK LEKEKSELKM EIDDMASNIE TVSKSKSNME
1260 1270 1280 1290 1300
RMCRSVEDQF NEIKAKDDQQ TQLIHDLNMQ KARLQTQNGE LSHQVEEKES
1310 1320 1330 1340 1350
LVSQLTKSKQ ALTQQLEELK RQLEEETKAK NALAHALQSS RHDCDLLREQ
1360 1370 1380 1390 1400
YEEEQEGKAE LQRALSKANS EVAQWRTKYE TDAIQRTEEL EEAKKKLAQR
1410 1420 1430 1440 1450
LQEAEENTEA SNSKCASLEK TKQRLQGEVD DLMLDLERAN TACATLDKKQ
1460 1470 1480 1490 1500
RNFDKVLAEW KQKLDESQAE LEAAQKESRS LSTEIFKMRN AYEEVVDQLE
1510 1520 1530 1540 1550
TLRRENKNLQ EEISDLTEQI AETGKNLQEV EKTKKQVEQE KSDLQAALEE
1560 1570 1580 1590 1600
VEGSLEHEES KILRVQLELS QVKSELDRKV TEKDEEIEQI KRNSQRAVEA
1610 1620 1630 1640 1650
MQSVLDAEIR SRNDALRLKK KMEGDLNEME IQLSHANRQV AETQKHLRTV
1660 1670 1680 1690 1700
QGQLKDSQLH LDDAQRSNED LKEQLAIVER RNGLLQEELE EMKVALEQTE
1710 1720 1730 1740 1750
RTRRLSEQEL LDSSDRVQLL HSQNTSLINT KKKLEADLAQ CQAEVENSIQ
1760 1770 1780 1790 1800
ESRNAEEKAK KAITDAAMMA EELKKEQDTS AHLERMKKNL EQTVKDLQHR
1810 1820 1830 1840 1850
LDEAEQLALK GGKKQIQKLE ARVRELESEL DAEQKRGAEA LKGAHKYERK
1860 1870 1880 1890 1900
VKEMTYQAEE DRKNILRLQD LVDKLQAKVK SYKRQAEEAE EQANTQLSRC
1910 1920 1930
RRVQHELEEA EERADIAESQ VNKLRAKSRD VGGQKMEE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM0QWL0 | M0QWL0_MOUSE | Myosin, heavy polypeptide 13, skele... | Myh13 | 223 | Annotation score: |
Sequence databases
RefSeqi | NP_001074719.1, NM_001081250.1 |
Genome annotation databases
Ensembli | ENSMUST00000081911; ENSMUSP00000080584; ENSMUSG00000060180 ENSMUST00000108684; ENSMUSP00000104324; ENSMUSG00000060180 ENSMUST00000180845; ENSMUSP00000137731; ENSMUSG00000060180 |
GeneIDi | 544791 |
KEGGi | mmu:544791 |
UCSCi | uc007jmt.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | NP_001074719.1, NM_001081250.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000104324 |
Proteomic databases
ProteomicsDBi | 341089 |
Protocols and materials databases
Antibodypediai | 3434, 21 antibodies from 12 providers |
Genome annotation databases
Ensembli | ENSMUST00000081911; ENSMUSP00000080584; ENSMUSG00000060180 ENSMUST00000108684; ENSMUSP00000104324; ENSMUSG00000060180 ENSMUST00000180845; ENSMUSP00000137731; ENSMUSG00000060180 |
GeneIDi | 544791 |
KEGGi | mmu:544791 |
UCSCi | uc007jmt.1, mouse |
Organism-specific databases
CTDi | 8735 |
MGIi | MGI:1339967, Myh13 |
VEuPathDBi | HostDB:ENSMUSG00000060180 |
Phylogenomic databases
eggNOGi | KOG0161, Eukaryota |
GeneTreei | ENSGT00940000162543 |
HOGENOMi | CLU_000192_8_1_1 |
OMAi | MDYENDP |
OrthoDBi | 47111at2759 |
TreeFami | TF314375 |
Miscellaneous databases
BioGRID-ORCSi | 544791, 2 hits in 63 CRISPR screens |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000060180, Expressed in skeletal muscle tissue and 51 other tissues |
Family and domain databases
CDDi | cd14923, MYSc_Myh13, 1 hit |
Gene3Di | 1.20.5.370, 4 hits 2.30.30.360, 1 hit 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR042702, Myh13_MYSc IPR001609, Myosin_head_motor_dom IPR004009, Myosin_N IPR008989, Myosin_S1_N IPR002928, Myosin_tail IPR027417, P-loop_NTPase IPR014751, XRCC4-like_C |
Pfami | View protein in Pfam PF00063, Myosin_head, 1 hit PF02736, Myosin_N, 1 hit PF01576, Myosin_tail_1, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM00242, MYSc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit PS51456, MYOSIN_MOTOR, 1 hit PS51844, SH3_LIKE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B1AR69_MOUSE | |
Accessioni | B1AR69Primary (citable) accession number: B1AR69 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 8, 2008 |
Last sequence update: | April 8, 2008 | |
Last modified: | January 19, 2022 | |
This is version 118 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |