Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Keratin, type I cuticular Ha6

Gene

Krt36

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei342StutterSequence analysis1

GO - Molecular functioni

  • structural constituent of epidermis Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha6By similarity
Alternative name(s):
Keratin-36Imported
Short name:
K36
Keratin-5Imported
MHRa-1Imported
Type I keratin 48 kDa1 Publication
Gene namesi
Name:Krt36Imported
Synonyms:Hra-1Imported, Krt1-22Imported, Krt1-5Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:109364 Krt36

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003639891 – 473Keratin, type I cuticular Ha6Add BLAST473

Proteomic databases

MaxQBiB1AQ75
PaxDbiB1AQ75
PeptideAtlasiB1AQ75
PRIDEiB1AQ75

PTM databases

iPTMnetiB1AQ75
PhosphoSitePlusiB1AQ75

Expressioni

Tissue specificityi

In skin, only expressed in the suprabasal cells of tail scale epidermis. Suprabasally expressed in stratified squamous epithelia and also in the posterior unit of the complex filiform papillae of tongue. Expressed in rare anatomical sites in which an orthokeratinized stratum corneum would be too soft and a hard keratinized structure would be too rigid to meet the functional requirement of the respective epithelia.1 Publication

Inductioni

mRNA synthesis is suppressed during retinoic acid-mediated orthokeratotic conversion of tail scale epidermis.1 Publication

Gene expression databases

BgeeiENSMUSG00000020916 Expressed in 50 organ(s), highest expression level in tail skin
GenevisibleiB1AQ75 MM

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103039

Structurei

3D structure databases

ProteinModelPortaliB1AQ75
SMRiB1AQ75
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 404IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 93HeadSequence analysisAdd BLAST93
Regioni94 – 128Coil 1ASequence analysisAdd BLAST35
Regioni129 – 139Linker 1Sequence analysisAdd BLAST11
Regioni140 – 240Coil 1BSequence analysisAdd BLAST101
Regioni241 – 256Linker 12Sequence analysisAdd BLAST16
Regioni257 – 400Coil 2Sequence analysisAdd BLAST144
Regioni401 – 473TailSequence analysisAdd BLAST73

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFTF Eukaryota
ENOG410Y9IV LUCA
GeneTreeiENSGT00900000140814
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiB1AQ75
KOiK07604
OMAiECKPAVR
OrthoDBiEOG091G087I
PhylomeDBiB1AQ75
TreeFamiTF332742

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

B1AQ75-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATQICTPTF SAGSAKGLCG TSGSFSRISS IHSMGSCRAP SLVGTVGSVS
60 70 80 90 100
SFRTGFSGPG SCLPGSYLSS GCHSSGFAGS GGWFCEGAFN GNEKATMQIL
110 120 130 140 150
NDRLANYLEK VRQLEQENTQ LECRIREWYE CQIPYICPDY QSYFKTAEEL
160 170 180 190 200
QQKILLTKSE NARLILQIDN AKLAADDFRT KYETELSLRQ LVEADINGLR
210 220 230 240 250
RILDELTLCK ADLEAQVESL KEELLCLKRN HEEEVNALRS QLGDRLNVEV
260 270 280 290 300
DAAPPVDLNK ILDDMRCQYE TLVENNRRDV EAWFNTQTEE LNQQVVSSSE
310 320 330 340 350
QLQCCQTEII ELRRTVNSLE IELQAQQSMR NSLESTLAET EARYSSQLGQ
360 370 380 390 400
MQCLITNVES QLAEIRCDLE RQNHEYQVLL DVKARLESEI ATYRRLLDGE
410 420 430 440 450
DCKLPAHPCS TECKPAVRVP YIPSTTCTPA GPCTPAGPCT PAPQVSTQIR
460 470
TITEEIRDGR VISSREHVVP RAM
Length:473
Mass (Da):52,790
Last modified:April 8, 2008 - v1
Checksum:iA492B6686024FCA8
GO

Sequence cautioni

The sequence CAA46480 differs from that shown. Reason: Frameshift at position 418.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti285 – 286NT → IA in CAA46480 (PubMed:1385239).Curated2
Sequence conflicti316 – 318VNS → SQL in CAA46480 (PubMed:1385239).Curated3
Sequence conflicti326Q → R in CAA46480 (PubMed:1385239).Curated1
Sequence conflicti331N → H in CAA46480 (PubMed:1385239).Curated1
Sequence conflicti357N → K in CAA46480 (PubMed:1385239).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590873, AL662808 Genomic DNA Translation: CAM17771.1
AL662808, AL590873 Genomic DNA Translation: CAM15791.1
X65506 mRNA Translation: CAA46480.1 Frameshift.
CCDSiCCDS48929.1
PIRiI48660 S21388
RefSeqiNP_001167570.1, NM_001174099.1
XP_017169791.1, XM_017314302.1
UniGeneiMm.306829
Mm.401866

Genome annotation databases

EnsembliENSMUST00000107416; ENSMUSP00000103039; ENSMUSG00000020916
GeneIDi16673
KEGGimmu:16673
UCSCiuc011yey.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590873, AL662808 Genomic DNA Translation: CAM17771.1
AL662808, AL590873 Genomic DNA Translation: CAM15791.1
X65506 mRNA Translation: CAA46480.1 Frameshift.
CCDSiCCDS48929.1
PIRiI48660 S21388
RefSeqiNP_001167570.1, NM_001174099.1
XP_017169791.1, XM_017314302.1
UniGeneiMm.306829
Mm.401866

3D structure databases

ProteinModelPortaliB1AQ75
SMRiB1AQ75
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103039

PTM databases

iPTMnetiB1AQ75
PhosphoSitePlusiB1AQ75

Proteomic databases

MaxQBiB1AQ75
PaxDbiB1AQ75
PeptideAtlasiB1AQ75
PRIDEiB1AQ75

Protocols and materials databases

DNASUi16673
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107416; ENSMUSP00000103039; ENSMUSG00000020916
GeneIDi16673
KEGGimmu:16673
UCSCiuc011yey.1 mouse

Organism-specific databases

CTDi8689
MGIiMGI:109364 Krt36

Phylogenomic databases

eggNOGiENOG410IFTF Eukaryota
ENOG410Y9IV LUCA
GeneTreeiENSGT00900000140814
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiB1AQ75
KOiK07604
OMAiECKPAVR
OrthoDBiEOG091G087I
PhylomeDBiB1AQ75
TreeFamiTF332742

Enzyme and pathway databases

ReactomeiR-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Miscellaneous databases

PROiPR:B1AQ75
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020916 Expressed in 50 organ(s), highest expression level in tail skin
GenevisibleiB1AQ75 MM

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKRT36_MOUSE
AccessioniPrimary (citable) accession number: B1AQ75
Secondary accession number(s): Q61861
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: April 8, 2008
Last modified: November 7, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again