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UniProtKB - B1AM99 (B1AM99_HUMAN)

Entry version 113 (10 Feb 2021)
Sequence version 1 (08 Apr 2008)
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Protein
Submitted name:

Contactin-associated protein-like 3

Gene

CNTNAP3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesionARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Contactin-associated protein-like 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CNTNAP3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:13834, CNTNAP3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000106714.17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000106714

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500276180826 – 745Sequence analysisAdd BLAST720

Keywords - PTMi

Disulfide bondARBA annotation, GlycoproteinARBA annotation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		B1AM99

PeptideAtlas

More...PeptideAtlasi		B1AM99

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		3189

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000106714, Expressed in lower esophagus and 111 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		B1AM99, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 177F5/8 type CInterPro annotationAdd BLAST147
Domaini183 – 364LAM_G_DOMAINInterPro annotationAdd BLAST182
Domaini370 – 545LAM_G_DOMAINInterPro annotationAdd BLAST176
Domaini547 – 584EGF-likeInterPro annotationAdd BLAST38
Domaini583 – 634Fibrinogen C-terminalInterPro annotationAdd BLAST52

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the neurexin family.ARBA annotation

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, RepeatARBA annotation, SignalSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160228

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_025845_1_0_1

Family and domain databases

Conserved Domains Database

More...CDDi		cd00057, FA58C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.260, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028873, CASPR3
IPR013320, ConA-like_dom_sf
IPR000742, EGF-like_dom
IPR000421, FA58C
IPR036056, Fibrinogen-like_C
IPR002181, Fibrinogen_a/b/g_C_dom
IPR008979, Galactose-bd-like_sf
IPR001791, Laminin_G

The PANTHER Classification System

More...PANTHERi		PTHR15036:SF36, PTHR15036:SF36, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00008, EGF, 1 hit
PF00754, F5_F8_type_C, 1 hit
PF02210, Laminin_G_2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00231, FA58C, 1 hit
SM00282, LamG, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49785, SSF49785, 1 hit
SSF49899, SSF49899, 2 hits
SSF56496, SSF56496, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50026, EGF_3, 1 hit
PS01285, FA58C_1, 1 hit
PS01286, FA58C_2, 1 hit
PS50022, FA58C_3, 1 hit
PS51406, FIBRINOGEN_C_2, 1 hit
PS50025, LAM_G_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

B1AM99-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASVAWAVLK VLLLLPTQTW SPVGAGNPPD CDAPLASALP RSSFSSSSEL 
        60         70         80         90        100
SSSHGPGFSR LNRRDGAGGW TPLVSNKYQW LQIDLGERME VTAVATQGGY 
       110        120        130        140        150
GSSDWVTSYL LMFSDGGRNW KQYRREESIW GFPGNTNADS VVHYRLQPPF 
       160        170        180        190        200
EARFLRFLPL AWNPRGRIGM RIEVYGCAYK SEVVYFDGQS ALLYRLDKKP 
       210        220        230        240        250
LKPIRDVISL KFKAMQSNGI LLHREGQHGN HITLELIKGK LVFFLNSGNA 
       260        270        280        290        300
KLPSTIAPVT LTLGSLLDDQ HWHSVLIELL DTQVNFTVDK HTHHFQAKGD 
       310        320        330        340        350
SSYLDLNFEI SFGGIPTPGR SRAFRRKSFH GCLENLYYNG VDVTELAKKH 
       360        370        380        390        400
KPQILMMGNV SFSCPQPQTV PVTFLSSRSY LALPGNSGED KVSVTFQFRT 
       410        420        430        440        450
WNRAGHLLFG ELRRGSGSFV LFLKDGKLKL SLFQPGQSPR NVTAGAGLND 
       460        470        480        490        500
GQWHSVSFSA KWSHMNVVVD DDTAVQPLVA VLIDSGDTYY FGGCLDNSSG 
       510        520        530        540        550
SGCKSPLGGF QGCLRLITIG DKAVDPILVQ QGALGSFRDL QIDSCGITDR 
       560        570        580        590        600
CLPSYCEHGG ECSQSWDTFS CDCLGTGYTG ETCHSSLYEQ SCEAHKHRGN 
       610        620        630        640        650
PSGLYYIDAD GSGPLGPFLV YCNMTDAAWT VVQHGGPDAV TLRGAPSGHP 
       660        670        680        690        700
RSAVSFAYAA GAGQLRSAVN LAERCEQRLA LRCGTARRPD SRDGTPLSWW 
       710        720        730        740 
VGRTNETHTS WGGSLPDAQK CTCGLEGNCI DSQYYCNCDA GRNEW
Length:745
Mass (Da):81,570
Last modified:April 8, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3F24E5FFE89718DA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9BZ76CNTP3_HUMAN
Contactin-associated protein-like 3
CNTNAP3 CASPR3, KIAA1714
1,288Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6NC89A6NC89_HUMAN
Contactin-associated protein-like 3
CNTNAP3
1,207Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AMA2B1AMA2_HUMAN
Contactin-associated protein-like 3
CNTNAP3
1,039Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2X6F2Z2X6_HUMAN
Contactin-associated protein-like 3
CNTNAP3
604Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL162501 Genomic DNA No translation available.
AL353729 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000377659; ENSP00000366887; ENSG00000106714

UCSC genome browser

More...UCSCi		uc064teo.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162501 Genomic DNA No translation available.
AL353729 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

MaxQBiB1AM99
PeptideAtlasiB1AM99
ProteomicsDBi3189

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		12082, 57 antibodies

Genome annotation databases

EnsembliENST00000377659; ENSP00000366887; ENSG00000106714
UCSCiuc064teo.1, human

Organism-specific databases

HGNCiHGNC:13834, CNTNAP3
OpenTargetsiENSG00000106714
VEuPathDBiHostDB:ENSG00000106714.17

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00940000160228
HOGENOMiCLU_025845_1_0_1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CNTNAP3, human

Gene expression databases

BgeeiENSG00000106714, Expressed in lower esophagus and 111 other tissues
ExpressionAtlasiB1AM99, baseline and differential

Family and domain databases

CDDicd00057, FA58C, 1 hit
Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR028873, CASPR3
IPR013320, ConA-like_dom_sf
IPR000742, EGF-like_dom
IPR000421, FA58C
IPR036056, Fibrinogen-like_C
IPR002181, Fibrinogen_a/b/g_C_dom
IPR008979, Galactose-bd-like_sf
IPR001791, Laminin_G
PANTHERiPTHR15036:SF36, PTHR15036:SF36, 1 hit
PfamiView protein in Pfam
PF00008, EGF, 1 hit
PF00754, F5_F8_type_C, 1 hit
PF02210, Laminin_G_2, 2 hits
SMARTiView protein in SMART
SM00231, FA58C, 1 hit
SM00282, LamG, 2 hits
SUPFAMiSSF49785, SSF49785, 1 hit
SSF49899, SSF49899, 2 hits
SSF56496, SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS50026, EGF_3, 1 hit
PS01285, FA58C_1, 1 hit
PS01286, FA58C_2, 1 hit
PS50022, FA58C_3, 1 hit
PS51406, FIBRINOGEN_C_2, 1 hit
PS50025, LAM_G_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB1AM99_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B1AM99
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: February 10, 2021
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health

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