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Protein
Submitted name:

Probable global transcription activator SNF2L2

Gene

SMARCA2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Probable global transcription activator SNF2L2Imported
Gene namesi
Name:SMARCA2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000080503.20
HGNCiHGNC:11098 SMARCA2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000080503

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_500276180027 – 278Sequence analysisAdd BLAST252

Proteomic databases

MaxQBiB1ALF6
PeptideAtlasiB1ALF6
PRIDEiB1ALF6

Expressioni

Gene expression databases

BgeeiENSG00000080503 Expressed in 237 organ(s), highest expression level in testis
ExpressionAtlasiB1ALF6 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliB1ALF6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini107 – 177BromoInterPro annotationAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili40 – 60Sequence analysisAdd BLAST21
Coiled coili187 – 217Sequence analysisAdd BLAST31

Keywords - Domaini

BromodomainPROSITE-ProRule annotationSAAS annotation, Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00550000074659
HOGENOMiHOG000049057
HOVERGENiHBG062263

Family and domain databases

Gene3Di1.20.920.10, 1 hit
InterProiView protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR030088 SMARCA2
PANTHERiPTHR10799:SF541 PTHR10799:SF541, 1 hit
PfamiView protein in Pfam
PF00439 Bromodomain, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 34 potential isoforms that are computationally mapped.iShow all

B1ALF6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLMKRLAARC FAGLLILSPL TVISDSRPAD SGKAIEDGNL EEMEEEVRLK
60 70 80 90 100
KRKRRRNVDK DPAKEDVEKA KKRRGRPPAE KLSPNPPKLT KQMNAIIDTV
110 120 130 140 150
INYKDSSGRQ LSEVFIQLPS RKELPEYYEL IRKPVDFKKI KERIRNHKYR
160 170 180 190 200
SLGDLEKDVM LLCHNAQTFN LEGSQIYEDS IVLQSVFKSA RQKIAKEEES
210 220 230 240 250
EDESNEEEEE EDEEESESEA KSVKVKIKLN KKDDKGRDKG KGKKRPNRGK
260 270
AKPVVSDFDS DEEQDEREQS EGSGTDDE
Length:278
Mass (Da):31,979
Last modified:April 8, 2008 - v1
Checksum:i5766E7798DBF003B
GO

Computationally mapped potential isoform sequencesi

There are 34 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P51531SMCA2_HUMAN
Probable global transcription activ...
SMARCA2 BAF190B, BRM, SNF2A, SNF2L2
1,590Annotation score:
F6VDE0F6VDE0_HUMAN
Probable global transcription activ...
SMARCA2
1,514Annotation score:
A0A1B0GWA8A0A1B0GWA8_HUMAN
Probable global transcription activ...
SMARCA2
279Annotation score:
A0A1B0GU54A0A1B0GU54_HUMAN
Probable global transcription activ...
SMARCA2
288Annotation score:
A0A0U1RQZ9A0A0U1RQZ9_HUMAN
Probable global transcription activ...
SMARCA2
1,428Annotation score:
B4DNT1B4DNT1_HUMAN
Probable global transcription activ...
SMARCA2
276Annotation score:
F6XE55F6XE55_HUMAN
Probable global transcription activ...
SMARCA2
228Annotation score:
A0A0U1RQU0A0A0U1RQU0_HUMAN
Probable global transcription activ...
SMARCA2
200Annotation score:
A0A0U1RQX3A0A0U1RQX3_HUMAN
Probable global transcription activ...
SMARCA2
245Annotation score:
A0A0U1RQW7A0A0U1RQW7_HUMAN
Probable global transcription activ...
SMARCA2
229Annotation score:
There are more potential isoformsShow all

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138755 Genomic DNA No translation available.
AL359076 Genomic DNA No translation available.
AL591644 Genomic DNA No translation available.
RefSeqiNP_001276329.1, NM_001289400.1
UniGeneiHs.298990
Hs.644901

Genome annotation databases

EnsembliENST00000302401; ENSP00000305411; ENSG00000080503
GeneIDi6595
UCSCiuc003zhe.4 human

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138755 Genomic DNA No translation available.
AL359076 Genomic DNA No translation available.
AL591644 Genomic DNA No translation available.
RefSeqiNP_001276329.1, NM_001289400.1
UniGeneiHs.298990
Hs.644901

3D structure databases

ProteinModelPortaliB1ALF6
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiB1ALF6
PeptideAtlasiB1ALF6
PRIDEiB1ALF6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302401; ENSP00000305411; ENSG00000080503
GeneIDi6595
UCSCiuc003zhe.4 human

Organism-specific databases

CTDi6595
EuPathDBiHostDB:ENSG00000080503.20
HGNCiHGNC:11098 SMARCA2
OpenTargetsiENSG00000080503
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00550000074659
HOGENOMiHOG000049057
HOVERGENiHBG062263

Miscellaneous databases

ChiTaRSiSMARCA2 human
GenomeRNAii6595

Gene expression databases

BgeeiENSG00000080503 Expressed in 237 organ(s), highest expression level in testis
ExpressionAtlasiB1ALF6 baseline and differential

Family and domain databases

Gene3Di1.20.920.10, 1 hit
InterProiView protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR030088 SMARCA2
PANTHERiPTHR10799:SF541 PTHR10799:SF541, 1 hit
PfamiView protein in Pfam
PF00439 Bromodomain, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB1ALF6_HUMAN
AccessioniPrimary (citable) accession number: B1ALF6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: September 12, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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