UniProtKB - B1AKP8 (B1AKP8_HUMAN)
Protein
Non-specific serine/threonine protein kinase
Gene
MTOR
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein-containing complex binding Source: InterPro
- protein serine kinase activity Source: UniProtKB-EC
- protein threonine kinase activity Source: UniProtKB-EC
Keywordsi
Molecular function | KinasePROSITE-ProRule annotationARBA annotation, Transferase |
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation) |
Gene namesi | Name:MTORImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3942, MTOR |
VEuPathDBi | HostDB:ENSG00000198793.12 |
PTM / Processingi
Proteomic databases
MaxQBi | B1AKP8 |
PeptideAtlasi | B1AKP8 |
PRIDEi | B1AKP8 |
ProteomicsDBi | 3090 |
Expressioni
Gene expression databases
Bgeei | ENSG00000198793, Expressed in testis and 180 other tissues |
ExpressionAtlasi | B1AKP8, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 187 | FATInterPro annotationAdd BLAST | 187 | |
Domaini | 387 – 754 | PI3K/PI4KInterPro annotationAdd BLAST | 368 | |
Domaini | 722 – 754 | FATCInterPro annotationAdd BLAST | 33 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 72 | DisorderedSequence analysisAdd BLAST | 72 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 10 – 25 | PolyampholyteSequence analysisAdd BLAST | 16 | |
Compositional biasi | 27 – 72 | PolarSequence analysisAdd BLAST | 46 |
Sequence similaritiesi
Belongs to the PI3/PI4-kinase family.ARBA annotation
Keywords - Domaini
RepeatARBA annotationPhylogenomic databases
GeneTreei | ENSGT00930000151037 |
HOGENOMi | CLU_000178_6_2_1 |
Family and domain databases
Gene3Di | 1.10.1070.11, 1 hit 1.20.120.150, 1 hit |
InterProi | View protein in InterPro IPR003152, FATC_dom IPR009076, FRB_dom IPR036738, FRB_sf IPR011009, Kinase-like_dom_sf IPR000403, PI3/4_kinase_cat_dom IPR036940, PI3/4_kinase_cat_sf IPR018936, PI3/4_kinase_CS IPR003151, PIK-rel_kinase_FAT IPR014009, PIK_FAT IPR026683, TOR |
PANTHERi | PTHR11139:SF9, PTHR11139:SF9, 1 hit |
Pfami | View protein in Pfam PF02259, FAT, 1 hit PF02260, FATC, 1 hit PF08771, FRB_dom, 1 hit PF00454, PI3_PI4_kinase, 1 hit |
SMARTi | View protein in SMART SM01343, FATC, 1 hit SM00146, PI3Kc, 1 hit |
SUPFAMi | SSF47212, SSF47212, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51189, FAT, 1 hit PS51190, FATC, 1 hit PS00915, PI3_4_KINASE_1, 1 hit PS00916, PI3_4_KINASE_2, 1 hit PS50290, PI3_4_KINASE_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
B1AKP8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNFEAVLHYK HQNQARDEKK KLRHASGANI TNATTAATTA ATATTTASTE
60 70 80 90 100
GSNSESEAES TENSPTPSPL QKKVTEDLSK TLLMYTVPAV QGFFRSISLS
110 120 130 140 150
RGNNLQDTLR VLTLWFDYGH WPDVNEALVE GVKAIQIDTW LQVIPQLIAR
160 170 180 190 200
IDTPRPLVGR LIHQLLTDIG RYHPQALIYP LTVASKSTTT ARHNAANKIL
210 220 230 240 250
KNMCEHSNTL VQQAMMVSEE LIRVAILWHE MWHEGLEEAS RLYFGERNVK
260 270 280 290 300
GMFEVLEPLH AMMERGPQTL KETSFNQAYG RDLMEAQEWC RKYMKSGNVK
310 320 330 340 350
DLTQAWDLYY HVFRRISKQL PQLTSLELQY VSPKLLMCRD LELAVPGTYD
360 370 380 390 400
PNQPIIRIQS IAPSLQVITS KQRPRKLTLM GSNGHEFVFL LKGHEDLRQD
410 420 430 440 450
ERVMQLFGLV NTLLANDPTS LRKNLSIQRY AVIPLSTNSG LIGWVPHCDT
460 470 480 490 500
LHALIRDYRE KKKILLNIEH RIMLRMAPDY DHLTLMQKVE VFEHAVNNTA
510 520 530 540 550
GDDLAKLLWL KSPSSEVWFD RRTNYTRSLA VMSMVGYILG LGDRHPSNLM
560 570 580 590 600
LDRLSGKILH IDFGDCFEVA MTREKFPEKI PFRLTRMLTN AMEVTGLDGN
610 620 630 640 650
YRITCHTVME VLREHKDSVM AVLEAFVYDP LLNWRLMDTN TKGNKRSRTR
660 670 680 690 700
TDSYSAGQSV EILDGVELGE PAHKKTGTTV PESIHSFIGD GLVKPEALNK
710 720 730 740 750
KAIQIINRVR DKLTGRDFSH DDTLDVPTQV ELLIKQATSH ENLCQCYIGW
CPFW
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP42345 | MTOR_HUMAN | Serine/threonine-protein kinase mTO... | MTOR FRAP, FRAP1, FRAP2, RAFT1, RAPT1 | 2,549 | Annotation score: | ||
B1AKQ2 | B1AKQ2_HUMAN | Serine/threonine-protein kinase mTO... | MTOR | 161 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL049653 Genomic DNA No translation available. AL109811 Genomic DNA No translation available. AL391561 Genomic DNA No translation available. KF495866 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000376838; ENSP00000366034; ENSG00000198793 |
UCSCi | uc001asc.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL049653 Genomic DNA No translation available. AL109811 Genomic DNA No translation available. AL391561 Genomic DNA No translation available. KF495866 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | B1AKP8 |
PeptideAtlasi | B1AKP8 |
PRIDEi | B1AKP8 |
ProteomicsDBi | 3090 |
Protocols and materials databases
Antibodypediai | 3566, 1762 antibodies |
Genome annotation databases
Ensembli | ENST00000376838; ENSP00000366034; ENSG00000198793 |
UCSCi | uc001asc.4, human |
Organism-specific databases
HGNCi | HGNC:3942, MTOR |
OpenTargetsi | ENSG00000198793 |
VEuPathDBi | HostDB:ENSG00000198793.12 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00930000151037 |
HOGENOMi | CLU_000178_6_2_1 |
Miscellaneous databases
ChiTaRSi | MTOR, human |
Gene expression databases
Bgeei | ENSG00000198793, Expressed in testis and 180 other tissues |
ExpressionAtlasi | B1AKP8, baseline and differential |
Family and domain databases
Gene3Di | 1.10.1070.11, 1 hit 1.20.120.150, 1 hit |
InterProi | View protein in InterPro IPR003152, FATC_dom IPR009076, FRB_dom IPR036738, FRB_sf IPR011009, Kinase-like_dom_sf IPR000403, PI3/4_kinase_cat_dom IPR036940, PI3/4_kinase_cat_sf IPR018936, PI3/4_kinase_CS IPR003151, PIK-rel_kinase_FAT IPR014009, PIK_FAT IPR026683, TOR |
PANTHERi | PTHR11139:SF9, PTHR11139:SF9, 1 hit |
Pfami | View protein in Pfam PF02259, FAT, 1 hit PF02260, FATC, 1 hit PF08771, FRB_dom, 1 hit PF00454, PI3_PI4_kinase, 1 hit |
SMARTi | View protein in SMART SM01343, FATC, 1 hit SM00146, PI3Kc, 1 hit |
SUPFAMi | SSF47212, SSF47212, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51189, FAT, 1 hit PS51190, FATC, 1 hit PS00915, PI3_4_KINASE_1, 1 hit PS00916, PI3_4_KINASE_2, 1 hit PS50290, PI3_4_KINASE_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B1AKP8_HUMAN | |
Accessioni | B1AKP8Primary (citable) accession number: B1AKP8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 8, 2008 |
Last sequence update: | April 8, 2008 | |
Last modified: | April 7, 2021 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |