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Protein
Submitted name:

Serine/threonine-protein kinase mTOR

Gene

MTOR

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Serine/threonine-protein kinase mTORImported
Gene namesi
Name:MTORImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000198793.12
HGNCiHGNC:3942 MTOR

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198793

PTM / Processingi

Proteomic databases

EPDiB1AKP8
MaxQBiB1AKP8
PeptideAtlasiB1AKP8
PRIDEiB1AKP8

Expressioni

Gene expression databases

BgeeiENSG00000198793
ExpressionAtlasiB1AKP8 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliB1AKP8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 187FATInterPro annotationAdd BLAST187
Domaini387 – 754PI3K/PI4KInterPro annotationAdd BLAST368
Domaini722 – 754FATCInterPro annotationAdd BLAST33

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.SAAS annotation

Phylogenomic databases

eggNOGiKOG0891 Eukaryota
COG5032 LUCA
GeneTreeiENSGT00920000149065
HOGENOMiHOG000049044
HOVERGENiHBG102007

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
1.20.120.150, 1 hit
InterProiView protein in InterPro
IPR003152 FATC_dom
IPR009076 FRB_dom
IPR036738 FRB_sf
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR003151 PIK-rel_kinase_FAT
IPR014009 PIK_FAT
IPR026683 TOR
PANTHERiPTHR11139:SF9 PTHR11139:SF9, 1 hit
PfamiView protein in Pfam
PF02259 FAT, 1 hit
PF02260 FATC, 1 hit
PF08771 FRB_dom, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
SMARTiView protein in SMART
SM01343 FATC, 1 hit
SM00146 PI3Kc, 1 hit
SUPFAMiSSF47212 SSF47212, 1 hit
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS51189 FAT, 1 hit
PS51190 FATC, 1 hit
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

B1AKP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFEAVLHYK HQNQARDEKK KLRHASGANI TNATTAATTA ATATTTASTE
60 70 80 90 100
GSNSESEAES TENSPTPSPL QKKVTEDLSK TLLMYTVPAV QGFFRSISLS
110 120 130 140 150
RGNNLQDTLR VLTLWFDYGH WPDVNEALVE GVKAIQIDTW LQVIPQLIAR
160 170 180 190 200
IDTPRPLVGR LIHQLLTDIG RYHPQALIYP LTVASKSTTT ARHNAANKIL
210 220 230 240 250
KNMCEHSNTL VQQAMMVSEE LIRVAILWHE MWHEGLEEAS RLYFGERNVK
260 270 280 290 300
GMFEVLEPLH AMMERGPQTL KETSFNQAYG RDLMEAQEWC RKYMKSGNVK
310 320 330 340 350
DLTQAWDLYY HVFRRISKQL PQLTSLELQY VSPKLLMCRD LELAVPGTYD
360 370 380 390 400
PNQPIIRIQS IAPSLQVITS KQRPRKLTLM GSNGHEFVFL LKGHEDLRQD
410 420 430 440 450
ERVMQLFGLV NTLLANDPTS LRKNLSIQRY AVIPLSTNSG LIGWVPHCDT
460 470 480 490 500
LHALIRDYRE KKKILLNIEH RIMLRMAPDY DHLTLMQKVE VFEHAVNNTA
510 520 530 540 550
GDDLAKLLWL KSPSSEVWFD RRTNYTRSLA VMSMVGYILG LGDRHPSNLM
560 570 580 590 600
LDRLSGKILH IDFGDCFEVA MTREKFPEKI PFRLTRMLTN AMEVTGLDGN
610 620 630 640 650
YRITCHTVME VLREHKDSVM AVLEAFVYDP LLNWRLMDTN TKGNKRSRTR
660 670 680 690 700
TDSYSAGQSV EILDGVELGE PAHKKTGTTV PESIHSFIGD GLVKPEALNK
710 720 730 740 750
KAIQIINRVR DKLTGRDFSH DDTLDVPTQV ELLIKQATSH ENLCQCYIGW

CPFW
Length:754
Mass (Da):85,901
Last modified:April 8, 2008 - v1
Checksum:i0AC837B2544A1CEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049653 Genomic DNA No translation available.
AL109811 Genomic DNA No translation available.
AL391561 Genomic DNA No translation available.
KF495866 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000376838; ENSP00000366034; ENSG00000198793
UCSCiuc001asc.4 human

Similar proteinsi

Entry informationi

Entry nameiB1AKP8_HUMAN
AccessioniPrimary (citable) accession number: B1AKP8
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: June 20, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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