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UniProtKB - B1AKN6 (B1AKN6_HUMAN)
Protein
Nuclear factor 1
Gene
NFIA
Organism
Homo sapiens (Human)
Status
Functioni
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
UniRule annotationGO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: InterPro
GO - Biological processi
- DNA replication Source: UniProtKB-KW
- positive regulation of transcription, DNA-templated Source: UniProt
Keywordsi
Molecular function | ActivatorUniRule annotationARBA annotation, DNA-bindingUniRule annotationARBA annotation |
Biological process | DNA replicationUniRule annotationARBA annotation, Transcription, Transcription regulationUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear factor 1UniRule annotation |
Gene namesi | Name:NFIA |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7784, NFIA |
VEuPathDBi | HostDB:ENSG00000162599 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotationARBA annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationPTM / Processingi
Proteomic databases
MaxQBi | B1AKN6 |
PeptideAtlasi | B1AKN6 |
PRIDEi | B1AKN6 |
ProteomicsDBi | 3084 |
Expressioni
Gene expression databases
Bgeei | ENSG00000162599, Expressed in oviduct epithelium and 225 other tissues |
ExpressionAtlasi | B1AKN6, baseline and differential |
Interactioni
Subunit structurei
Binds DNA as a homodimer.
UniRule annotationARBA annotationStructurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 194 | CTF/NF-IInterPro annotationAdd BLAST | 194 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 193 – 216 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 307 – 380 | DisorderedSequence analysisAdd BLAST | 74 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 307 – 328 | Pro residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 329 – 357 | Polar residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 366 – 380 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the CTF/NF-I family.UniRule annotation
Phylogenomic databases
GeneTreei | ENSGT00950000182916 |
HOGENOMi | CLU_012576_3_1_1 |
Family and domain databases
InterProi | View protein in InterPro IPR000647, CTF/NFI IPR020604, CTF/NFI_DNA-bd-dom IPR019739, CTF/NFI_DNA-bd_CS IPR019548, CTF/NFI_DNA-bd_N IPR003619, MAD_homology1_Dwarfin-type |
PANTHERi | PTHR11492, PTHR11492, 2 hits |
Pfami | View protein in Pfam PF00859, CTF_NFI, 1 hit PF03165, MH1, 1 hit PF10524, NfI_DNAbd_pre-N, 1 hit |
SMARTi | View protein in SMART SM00523, DWA, 1 hit |
PROSITEi | View protein in PROSITE PS00349, CTF_NFI_1, 1 hit PS51080, CTF_NFI_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 16 potential isoforms that are computationally mapped.Show allAlign All
B1AKN6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYSPLCLTQD EFHPFIEALL PHVRAFAYTW FNLQARKRKY FKKHEKRMSK
60 70 80 90 100
EEERAVKDEL LSEKPEVKQK WASRLLAKLR KDIRPEYRED FVLTVTGKKP
110 120 130 140 150
PCCVLSNPDQ KGKMRRIDCL RQADKVWRLD LVMVILFKGI PLESTDGERL
160 170 180 190 200
VKSPQCSNPG LCVQPHHIGV SVKELDLYLA YFVHAAGMPS PTTLKKSEKS
210 220 230 240 250
GFSSPSPSQT SSLGTAFTQH HRPVITGPRA SPHATPSTLH FPTSPIIQQP
260 270 280 290 300
GPYFSHPAIR YHPQETLKEF VQLVCPDAGQ QAGQVGFLNP NGSSQGKVHN
310 320 330 340 350
PFLPTPMLPP PPPPPMARPV PLPVPDTKPP TTSTEGGAAS PTSPTYSTPS
360 370 380
TSPANRFVSV GPRDPSFVNI PQQTQSWYLG
Computationally mapped potential isoform sequencesi
There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ12857 | NFIA_HUMAN | Nuclear factor 1 A-type | NFIA KIAA1439 | 509 | Annotation score: | ||
B1AKN8 | B1AKN8_HUMAN | Nuclear factor 1 | NFIA | 532 | Annotation score: | ||
B1AKN5 | B1AKN5_HUMAN | Nuclear factor 1 | NFIA | 487 | Annotation score: | ||
A0A590UK09 | A0A590UK09_HUMAN | Nuclear factor 1 | NFIA | 508 | Annotation score: | ||
B1AKN7 | B1AKN7_HUMAN | Nuclear factor 1 | NFIA | 466 | Annotation score: | ||
A0A590UK73 | A0A590UK73_HUMAN | Nuclear factor 1 | NFIA | 326 | Annotation score: | ||
S4R3K4 | S4R3K4_HUMAN | Nuclear factor 1 | NFIA | 186 | Annotation score: | ||
A0A590UJ82 | A0A590UJ82_HUMAN | CCAAT-box-binding transcription fac... | NFIA | 198 | Annotation score: | ||
S4R3W2 | S4R3W2_HUMAN | Nuclear factor 1 A-type | NFIA | 184 | Annotation score: | ||
A0A590UJU2 | A0A590UJU2_HUMAN | Nuclear factor 1 A-type | NFIA hCG_2032260 | 242 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC092784 Genomic DNA No translation available. AC096534 Genomic DNA No translation available. AC096947 Genomic DNA No translation available. AC099792 Genomic DNA No translation available. AL096888 Genomic DNA No translation available. AL355795 Genomic DNA No translation available. AL445198 Genomic DNA No translation available. AL445432 Genomic DNA No translation available. KF495972 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000371184.6; ENSP00000360226.1; ENSG00000162599.17 |
UCSCi | uc057hbo.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC092784 Genomic DNA No translation available. AC096534 Genomic DNA No translation available. AC096947 Genomic DNA No translation available. AC099792 Genomic DNA No translation available. AL096888 Genomic DNA No translation available. AL355795 Genomic DNA No translation available. AL445198 Genomic DNA No translation available. AL445432 Genomic DNA No translation available. KF495972 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | B1AKN6 |
PeptideAtlasi | B1AKN6 |
PRIDEi | B1AKN6 |
ProteomicsDBi | 3084 |
Protocols and materials databases
Antibodypediai | 1812, 277 antibodies from 31 providers |
Genome annotation databases
Ensembli | ENST00000371184.6; ENSP00000360226.1; ENSG00000162599.17 |
UCSCi | uc057hbo.1, human |
Organism-specific databases
HGNCi | HGNC:7784, NFIA |
OpenTargetsi | ENSG00000162599 |
VEuPathDBi | HostDB:ENSG00000162599 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00950000182916 |
HOGENOMi | CLU_012576_3_1_1 |
Miscellaneous databases
ChiTaRSi | NFIA, human |
Gene expression databases
Bgeei | ENSG00000162599, Expressed in oviduct epithelium and 225 other tissues |
ExpressionAtlasi | B1AKN6, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000647, CTF/NFI IPR020604, CTF/NFI_DNA-bd-dom IPR019739, CTF/NFI_DNA-bd_CS IPR019548, CTF/NFI_DNA-bd_N IPR003619, MAD_homology1_Dwarfin-type |
PANTHERi | PTHR11492, PTHR11492, 2 hits |
Pfami | View protein in Pfam PF00859, CTF_NFI, 1 hit PF03165, MH1, 1 hit PF10524, NfI_DNAbd_pre-N, 1 hit |
SMARTi | View protein in SMART SM00523, DWA, 1 hit |
PROSITEi | View protein in PROSITE PS00349, CTF_NFI_1, 1 hit PS51080, CTF_NFI_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B1AKN6_HUMAN | |
Accessioni | B1AKN6Primary (citable) accession number: B1AKN6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 8, 2008 |
Last sequence update: | April 8, 2008 | |
Last modified: | May 25, 2022 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |