UniProtKB - B1AKI9 (ISM1_HUMAN)
Protein
Isthmin-1
Gene
ISM1
Organism
Homo sapiens (Human)
Status
Functioni
Acts as an angiogenesis inhibitor.By similarity
GO - Biological processi
- negative regulation of angiogenesis Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | B1AKI9 |
Names & Taxonomyi
Protein namesi | Recommended name: Isthmin-1 |
Gene namesi | Name:ISM1 Synonyms:C20orf82, ISM |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000101230.5 |
HGNCi | HGNC:16213, ISM1 |
MIMi | 615793, gene |
neXtProti | NX_B1AKI9 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 140862 |
OpenTargetsi | ENSG00000101230 |
PharmGKBi | PA164721080 |
Miscellaneous databases
Pharosi | B1AKI9, Tbio |
Polymorphism and mutation databases
BioMutai | ISM1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | Sequence analysisAdd BLAST | 29 | |
ChainiPRO_0000348256 | 30 – 464 | Isthmin-1Add BLAST | 435 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 39 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 229 ↔ 256 | PROSITE-ProRule annotation | ||
Disulfide bondi | 233 ↔ 261 | PROSITE-ProRule annotation | ||
Disulfide bondi | 244 ↔ 248 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | B1AKI9 |
PeptideAtlasi | B1AKI9 |
PRIDEi | B1AKI9 |
ProteomicsDBi | 3068 |
PTM databases
GlyGeni | B1AKI9, 1 site |
iPTMneti | B1AKI9 |
PhosphoSitePlusi | B1AKI9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000101230, Expressed in right lobe of thyroid gland and 156 other tissues |
Genevisiblei | B1AKI9, HS |
Organism-specific databases
HPAi | ENSG00000101230, Tissue enhanced (thyroid) |
Interactioni
Subunit structurei
Interacts with integrin ITGAV/ITGB5.
By similarityProtein-protein interaction databases
STRINGi | 9606.ENSP00000262487 |
Miscellaneous databases
RNActi | B1AKI9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 218 – 262 | TSP type-1PROSITE-ProRule annotationAdd BLAST | 45 | |
Domaini | 289 – 452 | AMOPPROSITE-ProRule annotationAdd BLAST | 164 |
Domaini
The C-terminal AMOP domain plays an important role in the anti-angiogenic function of ISM1.By similarity
Sequence similaritiesi
Belongs to the isthmin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QR6G, Eukaryota |
GeneTreei | ENSGT00940000159062 |
HOGENOMi | CLU_030263_0_0_1 |
InParanoidi | B1AKI9 |
OMAi | EGDWSNW |
OrthoDBi | 876510at2759 |
PhylomeDBi | B1AKI9 |
TreeFami | TF331333 |
Family and domain databases
Gene3Di | 2.20.100.10, 1 hit |
InterProi | View protein in InterPro IPR005533, AMOP_dom IPR042413, ISM IPR000884, TSP1_rpt IPR036383, TSP1_rpt_sf |
PANTHERi | PTHR10239, PTHR10239, 1 hit |
Pfami | View protein in Pfam PF03782, AMOP, 1 hit PF00090, TSP_1, 1 hit |
SMARTi | View protein in SMART SM00723, AMOP, 1 hit SM00209, TSP1, 1 hit |
SUPFAMi | SSF82895, SSF82895, 1 hit |
PROSITEi | View protein in PROSITE PS50856, AMOP, 1 hit PS50092, TSP1, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
B1AKI9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVRLAAELLL LLGLLLLTLH ITVLRGSGAA DGPDAAAGNA SQAQLQNNLN
60 70 80 90 100
VGSDTTSETS FSLSKEAPRE HLDHQAAHQP FPRPRFRQET GHPSLQRDFP
110 120 130 140 150
RSFLLDLPNF PDLSKADING QNPNIQVTIE VVDGPDSEAD KDQHPENKPS
160 170 180 190 200
WSVPSPDWRA WWQRSLSLAR ANSGDQDYKY DSTSDDSNFL NPPRGWDHTA
210 220 230 240 250
PGHRTFETKD QPEYDSTDGE GDWSLWSVCS VTCGNGNQKR TRSCGYACTA
260 270 280 290 300
TESRTCDRPN CPGIEDTFRT AATEVSLLAG SEEFNATKLF EVDTDSCERW
310 320 330 340 350
MSCKSEFLKK YMHKVMNDLP SCPCSYPTEV AYSTADIFDR IKRKDFRWKD
360 370 380 390 400
ASGPKEKLEI YKPTARYCIR SMLSLESTTL AAQHCCYGDN MQLITRGKGA
410 420 430 440 450
GTPNLISTEF SAELHYKVDV LPWIICKGDW SRYNEARPPN NGQKCTESPS
460
DEDYIKQFQE AREY
Sequence cautioni
The sequence EAX10318 differs from that shown. Reason: Erroneous gene model prediction.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052664 | 193 | P → R. Corresponds to variant dbSNP:rs3747933Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL050320 Genomic DNA No translation available. AL133463 Genomic DNA No translation available. CH471133 Genomic DNA Translation: EAX10318.1 Sequence problems. BC017997 mRNA Translation: AAH17997.1 |
CCDSi | CCDS46579.1 |
RefSeqi | NP_543016.1, NM_080826.1 |
Genome annotation databases
Ensembli | ENST00000262487; ENSP00000262487; ENSG00000101230 |
GeneIDi | 140862 |
KEGGi | hsa:140862 |
UCSCi | uc010gce.2, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL050320 Genomic DNA No translation available. AL133463 Genomic DNA No translation available. CH471133 Genomic DNA Translation: EAX10318.1 Sequence problems. BC017997 mRNA Translation: AAH17997.1 |
CCDSi | CCDS46579.1 |
RefSeqi | NP_543016.1, NM_080826.1 |
3D structure databases
SMRi | B1AKI9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000262487 |
PTM databases
GlyGeni | B1AKI9, 1 site |
iPTMneti | B1AKI9 |
PhosphoSitePlusi | B1AKI9 |
Polymorphism and mutation databases
BioMutai | ISM1 |
Proteomic databases
PaxDbi | B1AKI9 |
PeptideAtlasi | B1AKI9 |
PRIDEi | B1AKI9 |
ProteomicsDBi | 3068 |
Protocols and materials databases
Antibodypediai | 52888, 64 antibodies |
Genome annotation databases
Ensembli | ENST00000262487; ENSP00000262487; ENSG00000101230 |
GeneIDi | 140862 |
KEGGi | hsa:140862 |
UCSCi | uc010gce.2, human |
Organism-specific databases
CTDi | 140862 |
DisGeNETi | 140862 |
EuPathDBi | HostDB:ENSG00000101230.5 |
GeneCardsi | ISM1 |
HGNCi | HGNC:16213, ISM1 |
HPAi | ENSG00000101230, Tissue enhanced (thyroid) |
MIMi | 615793, gene |
neXtProti | NX_B1AKI9 |
OpenTargetsi | ENSG00000101230 |
PharmGKBi | PA164721080 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QR6G, Eukaryota |
GeneTreei | ENSGT00940000159062 |
HOGENOMi | CLU_030263_0_0_1 |
InParanoidi | B1AKI9 |
OMAi | EGDWSNW |
OrthoDBi | 876510at2759 |
PhylomeDBi | B1AKI9 |
TreeFami | TF331333 |
Enzyme and pathway databases
PathwayCommonsi | B1AKI9 |
Miscellaneous databases
BioGRID-ORCSi | 140862, 6 hits in 843 CRISPR screens |
ChiTaRSi | ISM1, human |
GenomeRNAii | 140862 |
Pharosi | B1AKI9, Tbio |
PROi | PR:B1AKI9 |
RNActi | B1AKI9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000101230, Expressed in right lobe of thyroid gland and 156 other tissues |
Genevisiblei | B1AKI9, HS |
Family and domain databases
Gene3Di | 2.20.100.10, 1 hit |
InterProi | View protein in InterPro IPR005533, AMOP_dom IPR042413, ISM IPR000884, TSP1_rpt IPR036383, TSP1_rpt_sf |
PANTHERi | PTHR10239, PTHR10239, 1 hit |
Pfami | View protein in Pfam PF03782, AMOP, 1 hit PF00090, TSP_1, 1 hit |
SMARTi | View protein in SMART SM00723, AMOP, 1 hit SM00209, TSP1, 1 hit |
SUPFAMi | SSF82895, SSF82895, 1 hit |
PROSITEi | View protein in PROSITE PS50856, AMOP, 1 hit PS50092, TSP1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ISM1_HUMAN | |
Accessioni | B1AKI9Primary (citable) accession number: B1AKI9 Secondary accession number(s): Q8WVH9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 2, 2008 |
Last sequence update: | September 2, 2008 | |
Last modified: | December 2, 2020 | |
This is version 89 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations