UniProtKB - B1AK85 (B1AK85_HUMAN)
Protein
F-actin-capping protein subunit beta
Gene
CAPZB
Organism
Homo sapiens (Human)
Status
Functioni
F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.UniRule annotation
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
GO - Biological processi
- actin cytoskeleton organization Source: InterPro
- barbed-end actin filament capping Source: UniProtKB-UniRule
Keywordsi
Molecular function | Actin cappingUniRule annotationARBA annotation, Actin-bindingUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: F-actin-capping protein subunit betaUniRule annotation |
Gene namesi | Name:CAPZBImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000077549.17 |
HGNCi | HGNC:1491, CAPZB |
Subcellular locationi
Cytoskeleton
- cytoskeleton UniRule annotation
Other locations
- sarcomere ARBA annotation
Cytoskeleton
- F-actin capping protein complex Source: UniProtKB-UniRule
Other locations
- sarcomere Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, CytoskeletonUniRule annotationARBA annotationPTM / Processingi
Keywords - PTMi
PhosphoproteinARBA annotationProteomic databases
MaxQBi | B1AK85 |
PRIDEi | B1AK85 |
ProteomicsDBi | 3027 |
Expressioni
Gene expression databases
Bgeei | ENSG00000077549, Expressed in smooth muscle tissue and 249 other tissues |
Interactioni
Subunit structurei
Heterodimer of an alpha and a beta subunit.
UniRule annotationGO - Molecular functioni
- actin binding Source: UniProtKB-KW
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 29 | DisorderedSequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00390000017957 |
OrthoDBi | 1076134at2759 |
Family and domain databases
Gene3Di | 1.20.58.570, 1 hit 2.40.160.80, 1 hit |
InterProi | View protein in InterPro IPR037282, CapZ_alpha/beta IPR042276, CapZ_alpha/beta_2 IPR001698, CAPZB IPR043175, CAPZB_N IPR019771, F-actin_capping_bsu_CS |
PANTHERi | PTHR10619, PTHR10619, 1 hit |
Pfami | View protein in Pfam PF01115, F_actin_cap_B, 1 hit |
PRINTSi | PR00192, FACTINCAPB |
SUPFAMi | SSF90096, SSF90096, 1 hit |
PROSITEi | View protein in PROSITE PS00231, F_ACTIN_CAPPING_BETA, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
B1AK85-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPRQFQDTGF SRPGLGQPRR CDPEPRKSDQ QLDCALDLMR RLPPQQIEKN
60 70 80 90 100
LSDLIDLVPS LCEDLLSSVD QPLKIARDKV VGKDYLLCDY NRDGDSYRSP
110 120 130 140 150
WSNKYDPPLE DGAMPSARLR KLEVEANNAF DQYRDLYFEG GVSSVYLWDL
160 170 180 190 200
DHGFAGVILI KKAGDGSKKI KGCWDSIHVV EVQEKSSGRT AHYKLTSTVM
210 220 230 240 250
LWLQTNKSGS GTMNLGGSLT RQMEKDETVS DCSPHIANIG RLVEVCADFC
260
RQIKTRSSEE
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP47756 | CAPZB_HUMAN | F-actin-capping protein subunit bet... | CAPZB | 277 | Annotation score: | ||
B1AK88 | B1AK88_HUMAN | F-actin-capping protein subunit bet... | CAPZB hCG_41078 | 301 | Annotation score: | ||
B1AK87 | B1AK87_HUMAN | F-actin-capping protein subunit bet... | CAPZB | 244 | Annotation score: | ||
A0A6I8PRV6 | A0A6I8PRV6_HUMAN | F-actin-capping protein subunit bet... | CAPZB | 59 | Annotation score: | ||
A0A6I8PIN8 | A0A6I8PIN8_HUMAN | CapZ beta | CAPZB | 63 | Annotation score: | ||
A0A6I8PIH4 | A0A6I8PIH4_HUMAN | F-actin-capping protein subunit bet... | CAPZB | 47 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL035413 Genomic DNA No translation available. AL359199 Genomic DNA No translation available. AL445163 Genomic DNA No translation available. KF495883 Genomic DNA No translation available. AK125085 mRNA Translation: BAG54137.1 |
RefSeqi | NP_001193470.1, NM_001206541.2 |
Genome annotation databases
Ensembli | ENST00000264203; ENSP00000264203; ENSG00000077549 |
GeneIDi | 832 |
UCSCi | uc009vpk.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL035413 Genomic DNA No translation available. AL359199 Genomic DNA No translation available. AL445163 Genomic DNA No translation available. KF495883 Genomic DNA No translation available. AK125085 mRNA Translation: BAG54137.1 |
RefSeqi | NP_001193470.1, NM_001206541.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | B1AK85 |
PRIDEi | B1AK85 |
ProteomicsDBi | 3027 |
Protocols and materials databases
Antibodypediai | 7956, 280 antibodies |
Genome annotation databases
Ensembli | ENST00000264203; ENSP00000264203; ENSG00000077549 |
GeneIDi | 832 |
UCSCi | uc009vpk.5, human |
Organism-specific databases
CTDi | 832 |
EuPathDBi | HostDB:ENSG00000077549.17 |
HGNCi | HGNC:1491, CAPZB |
OpenTargetsi | ENSG00000077549 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000017957 |
OrthoDBi | 1076134at2759 |
Miscellaneous databases
BioGRID-ORCSi | 832, 693 hits in 857 CRISPR screens |
ChiTaRSi | CAPZB, human |
GenomeRNAii | 832 |
Gene expression databases
Bgeei | ENSG00000077549, Expressed in smooth muscle tissue and 249 other tissues |
Family and domain databases
Gene3Di | 1.20.58.570, 1 hit 2.40.160.80, 1 hit |
InterProi | View protein in InterPro IPR037282, CapZ_alpha/beta IPR042276, CapZ_alpha/beta_2 IPR001698, CAPZB IPR043175, CAPZB_N IPR019771, F-actin_capping_bsu_CS |
PANTHERi | PTHR10619, PTHR10619, 1 hit |
Pfami | View protein in Pfam PF01115, F_actin_cap_B, 1 hit |
PRINTSi | PR00192, FACTINCAPB |
SUPFAMi | SSF90096, SSF90096, 1 hit |
PROSITEi | View protein in PROSITE PS00231, F_ACTIN_CAPPING_BETA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B1AK85_HUMAN | |
Accessioni | B1AK85Primary (citable) accession number: B1AK85 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 8, 2008 |
Last sequence update: | April 8, 2008 | |
Last modified: | December 2, 2020 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |