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UniProtKB - B1AJZ9 (FHAD1_HUMAN)
Protein
Forkhead-associated domain-containing protein 1
Gene
FHAD1
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Forkhead-associated domain-containing protein 1Short name: FHA domain-containing protein 1 |
Gene namesi | Name:FHAD1 Synonyms:KIAA1937 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29408, FHAD1 |
neXtProti | NX_B1AJZ9 |
VEuPathDBi | HostDB:ENSG00000142621 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 114827 |
OpenTargetsi | ENSG00000142621 |
PharmGKBi | PA142671762 |
Miscellaneous databases
Pharosi | B1AJZ9, Tdark |
Genetic variation databases
BioMutai | FHAD1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000349365 | 1 – 1412 | Forkhead-associated domain-containing protein 1Add BLAST | 1412 |
Proteomic databases
EPDi | B1AJZ9 |
jPOSTi | B1AJZ9 |
MassIVEi | B1AJZ9 |
PaxDbi | B1AJZ9 |
PeptideAtlasi | B1AJZ9 |
PRIDEi | B1AJZ9 |
ProteomicsDBi | 3005 [B1AJZ9-1] 3006 [B1AJZ9-3] 3007 [B1AJZ9-4] |
PTM databases
iPTMneti | B1AJZ9 |
PhosphoSitePlusi | B1AJZ9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000142621, Expressed in testis and 138 other tissues |
ExpressionAtlasi | B1AJZ9, baseline and differential |
Genevisiblei | B1AJZ9, HS |
Organism-specific databases
HPAi | ENSG00000142621, Tissue enhanced (choroid plexus, fallopian tube, testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 125377, 4 interactors |
IntActi | B1AJZ9, 3 interactors |
STRINGi | 9606.ENSP00000351770 |
Miscellaneous databases
RNActi | B1AJZ9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 69 | FHAPROSITE-ProRule annotationAdd BLAST | 52 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 106 – 133 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 652 – 688 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 955 – 976 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 1086 – 1110 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 1372 – 1412 | DisorderedSequence analysisAdd BLAST | 41 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 250 – 466 | Sequence analysisAdd BLAST | 217 | |
Coiled coili | 692 – 963 | Sequence analysisAdd BLAST | 272 | |
Coiled coili | 999 – 1099 | Sequence analysisAdd BLAST | 101 | |
Coiled coili | 1141 – 1169 | Sequence analysisAdd BLAST | 29 | |
Coiled coili | 1292 – 1360 | Sequence analysisAdd BLAST | 69 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 955 – 971 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1086 – 1105 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1378 – 1395 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1396 – 1412 | Polar residuesSequence analysisAdd BLAST | 17 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QR8Q, Eukaryota |
GeneTreei | ENSGT00940000154171 |
HOGENOMi | CLU_005776_0_0_1 |
InParanoidi | B1AJZ9 |
OMAi | AQMCDIS |
OrthoDBi | 1273737at2759 |
PhylomeDBi | B1AJZ9 |
Family and domain databases
CDDi | cd00060, FHA, 1 hit |
InterProi | View protein in InterPro IPR000253, FHA_dom IPR008984, SMAD_FHA_dom_sf |
Pfami | View protein in Pfam PF00498, FHA, 1 hit |
SMARTi | View protein in SMART SM00240, FHA, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit |
PROSITEi | View protein in PROSITE PS50006, FHA_DOMAIN, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: B1AJZ9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKAYLKSAEG FFVLNKSTTI GRHENSDLVL QSPDIDNHHA LIEYNEAECS
60 70 80 90 100
FVLQDFNSRN GTFVNECHIQ NVAVKLIPGD ILRFGSAGLT YELVIENPPP
110 120 130 140 150
VSFPWMRGPA PWPGPQPPRA TQQPNQAPPP SHIPFHQGVQ PAPMQRSWSQ
160 170 180 190 200
AFPRPTVVLP ASHRRPVSAN KEMFSFVVDD ARKPPVIKQV WTNAMKLSEK
210 220 230 240 250
SVAEGIPGAV PPAEIYVEED LAQQDKDEII LLLGKEVSRL SDYEIESKYK
260 270 280 290 300
DVIIANLQNE VAELSQKVSE TTTSRQNEKE ISQKCQVLDE DIDAKQKEIQ
310 320 330 340 350
SLKSQISALQ KGYSKVLCQT LSERNSEITS LKNEGENLKR DNAITSGMVS
360 370 380 390 400
SLQKDILAKD EQVQQLKEEV SHLKSQNKDK DHQLEALGSR CSVLKEELKQ
410 420 430 440 450
EDAHRELREA QEKELKLCKT QIQDMEKEMK KLRAELRKSC TEQSVISRTL
460 470 480 490 500
REKSKVEEKL QEDSRRKLLQ LQEMGNRESV IKINLERAVG QLEHFRSQVI
510 520 530 540 550
KATYGRAKPF RDKPVTDQQL IEKITQVTED NINFQQKKWT LQKETQLSNS
560 570 580 590 600
KQEETTENIE KLRTSLDSCQ ACMKISCCSH DLKKEVDLLQ HLQVSPPVSG
610 620 630 640 650
LQKVVLDVLR HALSWLEEVE QLLRDLGILP SSPNKDQVQQ FSGNSAVFTA
660 670 680 690 700
GKAAGASGRE GEAERGEARA RGEAQSQNQA TDGREGGKAL EEYITQERNR
710 720 730 740 750
AKETLEEERK RMQELESLLA QQKKALAKSI TQEKNRVKEA LEEEQTRVQE
760 770 780 790 800
LEERLARQKE VLESSIAHEK RKAKEALESE KRKVQDLENH LTQQKEISES
810 820 830 840 850
NIAYEKRKAK EAMEKEKKKV QDLENRLTKQ KEELELKEQK EDVLNNKLSD
860 870 880 890 900
ALAMVEETQK TKATESLKAE SLALKLNETL AELETTKTKM IMVEERLILQ
910 920 930 940 950
QKMVKALQDE QESQRHGFEE EIMEYKEQIK QHAQTIVSLE EKLQKVTQHH
960 970 980 990 1000
KKIEGEIATL KDNDPAPKEE RPQDPLVAPM TESSAKDMAY EHLIDDLLAA
1010 1020 1030 1040 1050
QKEILSQQEV IMKLRKDLTE AHSRMSDLRG ELNEKQKMEL EQNVVLVQQQ
1060 1070 1080 1090 1100
SKELSVLKEK MAQMSSLVEK KDRELKALEE ALRASQEKHR LQLNTEKEQK
1110 1120 1130 1140 1150
PRKKTQTCDT SVQIEPVHTE AFSSSQEQQS FSDLGVRCKG SRHEEVIQRQ
1160 1170 1180 1190 1200
KKALSELRAR IKELEKARSP DHKDHQNESF LDLKNLRMEN NVQKILLDAK
1210 1220 1230 1240 1250
PDLPTLSRIE ILAPQNGLCN ARFGSAMEKS GKMDVAEALE LSEKLYLDMS
1260 1270 1280 1290 1300
KTLGSLMNIK NMSGHVSMKY LSRQEREKVN QLRQRDLDLV FDKITQLKNQ
1310 1320 1330 1340 1350
LGRKEELLRG YEKDVEQLRR SKVSIEMYQS QVAKLEDDIY KEAEEKALLK
1360 1370 1380 1390 1400
EALERMEHQL CQEKRINRAI RQQKVGTRKA SLKMDQEREM LRKETSSKSS
1410
QSLLHSKPSG KY
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YE38 | H0YE38_HUMAN | Forkhead-associated domain-containi... | FHAD1 | 701 | Annotation score: | ||
Q5JYW6 | Q5JYW6_HUMAN | Forkhead-associated domain-containi... | FHAD1 | 647 | Annotation score: | ||
A0A804HIA4 | A0A804HIA4_HUMAN | Forkhead-associated domain-containi... | FHAD1 | 1,479 | Annotation score: | ||
H0Y5P0 | H0Y5P0_HUMAN | Forkhead-associated domain-containi... | FHAD1 | 693 | Annotation score: | ||
H0YEU3 | H0YEU3_HUMAN | Forkhead-associated domain-containi... | FHAD1 | 120 | Annotation score: | ||
H0Y605 | H0Y605_HUMAN | Forkhead-associated domain-containi... | FHAD1 | 146 | Annotation score: | ||
H0YCR1 | H0YCR1_HUMAN | Forkhead-associated domain-containi... | FHAD1 | 470 | Annotation score: | ||
H0Y3C6 | H0Y3C6_HUMAN | Forkhead-associated domain-containi... | FHAD1 | 316 | Annotation score: | ||
Q5JYW1 | Q5JYW1_HUMAN | Forkhead-associated domain-containi... | FHAD1 | 251 | Annotation score: |
Sequence cautioni
The sequence BAC04126 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC04242 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC04913 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1004 | I → L in BAC04913 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1366 | I → V in BAC04913 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_046372 | 763 | E → K. Corresponds to variant dbSNP:rs12126178Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035366 | 758 – 793 | Missing in isoform 4. 1 PublicationAdd BLAST | 36 | |
Alternative sequenceiVSP_035369 | 1375 – 1412 | VGTRK…PSGKY → MRKLRLRELRGAQVHTAAGK DSWDLTPDPSDPGSPAVCRV GRKCRGARTEKRKRIDTLQL CLQRERQAGPAPPACSLNG in isoform 3. 1 PublicationAdd BLAST | 38 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL031283 Genomic DNA No translation available. AL158174 Genomic DNA No translation available. AL391094 Genomic DNA No translation available. AK093300 mRNA Translation: BAC04126.1 Different initiation. AK093883 mRNA Translation: BAC04242.1 Different initiation. AK096961 mRNA Translation: BAC04913.1 Different initiation. |
RefSeqi | NP_443161.1, NM_052929.1 [B1AJZ9-1] |
Genome annotation databases
Ensembli | ENST00000358897.8; ENSP00000351770.4; ENSG00000142621.21 ENST00000375998.8; ENSP00000365166.4; ENSG00000142621.21 |
GeneIDi | 114827 |
KEGGi | hsa:114827 |
UCSCi | uc001awb.2, human [B1AJZ9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL031283 Genomic DNA No translation available. AL158174 Genomic DNA No translation available. AL391094 Genomic DNA No translation available. AK093300 mRNA Translation: BAC04126.1 Different initiation. AK093883 mRNA Translation: BAC04242.1 Different initiation. AK096961 mRNA Translation: BAC04913.1 Different initiation. |
RefSeqi | NP_443161.1, NM_052929.1 [B1AJZ9-1] |
3D structure databases
AlphaFoldDBi | B1AJZ9 |
SMRi | B1AJZ9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125377, 4 interactors |
IntActi | B1AJZ9, 3 interactors |
STRINGi | 9606.ENSP00000351770 |
PTM databases
iPTMneti | B1AJZ9 |
PhosphoSitePlusi | B1AJZ9 |
Genetic variation databases
BioMutai | FHAD1 |
Proteomic databases
EPDi | B1AJZ9 |
jPOSTi | B1AJZ9 |
MassIVEi | B1AJZ9 |
PaxDbi | B1AJZ9 |
PeptideAtlasi | B1AJZ9 |
PRIDEi | B1AJZ9 |
ProteomicsDBi | 3005 [B1AJZ9-1] 3006 [B1AJZ9-3] 3007 [B1AJZ9-4] |
Protocols and materials databases
Antibodypediai | 63146, 92 antibodies from 13 providers |
DNASUi | 114827 |
Genome annotation databases
Ensembli | ENST00000358897.8; ENSP00000351770.4; ENSG00000142621.21 ENST00000375998.8; ENSP00000365166.4; ENSG00000142621.21 |
GeneIDi | 114827 |
KEGGi | hsa:114827 |
UCSCi | uc001awb.2, human [B1AJZ9-1] |
Organism-specific databases
CTDi | 114827 |
DisGeNETi | 114827 |
GeneCardsi | FHAD1 |
HGNCi | HGNC:29408, FHAD1 |
HPAi | ENSG00000142621, Tissue enhanced (choroid plexus, fallopian tube, testis) |
neXtProti | NX_B1AJZ9 |
OpenTargetsi | ENSG00000142621 |
PharmGKBi | PA142671762 |
VEuPathDBi | HostDB:ENSG00000142621 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QR8Q, Eukaryota |
GeneTreei | ENSGT00940000154171 |
HOGENOMi | CLU_005776_0_0_1 |
InParanoidi | B1AJZ9 |
OMAi | AQMCDIS |
OrthoDBi | 1273737at2759 |
PhylomeDBi | B1AJZ9 |
Enzyme and pathway databases
PathwayCommonsi | B1AJZ9 |
SignaLinki | B1AJZ9 |
Miscellaneous databases
BioGRID-ORCSi | 114827, 2 hits in 252 CRISPR screens |
ChiTaRSi | FHAD1, human |
GenomeRNAii | 114827 |
Pharosi | B1AJZ9, Tdark |
PROi | PR:B1AJZ9 |
RNActi | B1AJZ9, protein |
Gene expression databases
Bgeei | ENSG00000142621, Expressed in testis and 138 other tissues |
ExpressionAtlasi | B1AJZ9, baseline and differential |
Genevisiblei | B1AJZ9, HS |
Family and domain databases
CDDi | cd00060, FHA, 1 hit |
InterProi | View protein in InterPro IPR000253, FHA_dom IPR008984, SMAD_FHA_dom_sf |
Pfami | View protein in Pfam PF00498, FHA, 1 hit |
SMARTi | View protein in SMART SM00240, FHA, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit |
PROSITEi | View protein in PROSITE PS50006, FHA_DOMAIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FHAD1_HUMAN | |
Accessioni | B1AJZ9Primary (citable) accession number: B1AJZ9 Secondary accession number(s): Q0P6F5 Q8NA05 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 2, 2008 |
Last sequence update: | September 2, 2008 | |
Last modified: | May 25, 2022 | |
This is version 97 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports