UniProtKB - B1AJS0 (B1AJS0_HUMAN)
Protein
Protein-tyrosine-phosphatase
Gene
PTPRT
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:3.1.3.48ARBA annotation
GO - Molecular functioni
- protein tyrosine phosphatase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Hydrolase, Protein phosphataseARBA annotation, ReceptorARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PTPRTImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9682, PTPRT |
VEuPathDBi | HostDB:ENSG00000196090.12 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 747 – 768 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_5002760409 | 26 – 1431 | Protein-tyrosine-phosphataseSequence analysisAdd BLAST | 1406 |
Keywords - PTMi
GlycoproteinARBA annotationProteomic databases
MaxQBi | B1AJS0 |
PRIDEi | B1AJS0 |
ProteomicsDBi | 2985 |
Expressioni
Gene expression databases
Bgeei | ENSG00000196090, Expressed in middle temporal gyrus and 108 other tissues |
ExpressionAtlasi | B1AJS0, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 30 – 191 | MAMInterPro annotationAdd BLAST | 162 | |
Domaini | 193 – 284 | Ig-likeInterPro annotationAdd BLAST | 92 | |
Domaini | 291 – 384 | Fibronectin type-IIIInterPro annotationAdd BLAST | 94 | |
Domaini | 389 – 483 | Fibronectin type-IIIInterPro annotationAdd BLAST | 95 | |
Domaini | 484 – 590 | Fibronectin type-IIIInterPro annotationAdd BLAST | 107 | |
Domaini | 879 – 1133 | Tyrosine-protein phosphataseInterPro annotationAdd BLAST | 255 | |
Domaini | 1053 – 1124 | TYR_PHOSPHATASE_2InterPro annotationAdd BLAST | 72 | |
Domaini | 1165 – 1427 | Tyrosine-protein phosphataseInterPro annotationAdd BLAST | 263 | |
Domaini | 1341 – 1418 | TYR_PHOSPHATASE_2InterPro annotationAdd BLAST | 78 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 777 – 836 | DisorderedSequence analysisAdd BLAST | 60 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 797 – 836 | PolarSequence analysisAdd BLAST | 40 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domainARBA annotation, RepeatARBA annotation, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000155326 |
OrthoDBi | 411281at2759 |
Family and domain databases
CDDi | cd00063, FN3, 3 hits cd06263, MAM, 1 hit |
Gene3Di | 2.60.40.10, 4 hits 3.90.190.10, 2 hits |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR000998, MAM_dom IPR029021, Prot-tyrosine_phosphatase-like IPR000242, PTPase_domain IPR041201, PTPRJ_TM IPR016130, Tyr_Pase_AS IPR003595, Tyr_Pase_cat IPR000387, TYR_PHOSPHATASE_dom |
Pfami | View protein in Pfam PF00041, fn3, 2 hits PF00629, MAM, 1 hit PF18861, PTP_tm, 1 hit PF00102, Y_phosphatase, 2 hits |
PRINTSi | PR00020, MAMDOMAIN PR00700, PRTYPHPHTASE |
SMARTi | View protein in SMART SM00060, FN3, 3 hits SM00137, MAM, 1 hit SM00194, PTPc, 2 hits SM00404, PTPc_motif, 2 hits |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF49265, SSF49265, 2 hits SSF49899, SSF49899, 1 hit SSF52799, SSF52799, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 3 hits PS50835, IG_LIKE, 1 hit PS00740, MAM_1, 1 hit PS50060, MAM_2, 1 hit PS00383, TYR_PHOSPHATASE_1, 2 hits PS50056, TYR_PHOSPHATASE_2, 2 hits PS50055, TYR_PHOSPHATASE_PTP, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
B1AJS0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASLAALALS LLLRLQLPPL PGARAQSAAG GCSFDEHYSN CGYSVALGTN
60 70 80 90 100
GFTWEQINTW EKPMLDQAVP TGSFMMVNSS GRASGQKAHL LLPTLKENDT
110 120 130 140 150
HCIDFHYYFS SRDRSSPGAL NVYVKVNGGP QGNPVWNVSG VVTEGWVKAE
160 170 180 190 200
LAISTFWPHF YQVIFESVSL KGHPGYIAVD EVRVLAHPCR KAPHFLRLQN
210 220 230 240 250
VEVNVGQNAT FQCIAGGKWS QHDKLWLQQW NGRDTALMVT RVVNHRRFSA
260 270 280 290 300
TVSVADTAQR SVSKYRCVIR SDGGSGVSNY AELIVKEPPT PIAPPELLAV
310 320 330 340 350
GATYLWIKPN ANSIIGDGPI ILKEVEYRTT TGTWAETHIV DSPNYKLWHL
360 370 380 390 400
DPDVEYEIRV LLTRPGEGGT GPPGPPLTTR TKCADPVHGP QNVEIVDIRA
410 420 430 440 450
RQLTLQWEPF GYAVTRCHSY NLTVQYQYVF NQQQYEAEEV IQTSSHYTLR
460 470 480 490 500
GLRPFMTIRL RLLLSNPEGR MESEELVVQT EEDVPGAVPL ESIQGGPFEE
510 520 530 540 550
KIYIQWKPPN ETNGVITLYE INYKAVGSLD PSADLSSQRG KVFKLRNETH
560 570 580 590 600
HLFVGLYPGT TYSFTIKAST AKGFGPPVTT RIATKISAPS MPEYDTDTPL
610 620 630 640 650
NETDTTITVM LKPAQSRGAP VSVYQLVVKE ERLQKSRRAA DIIECFSVPV
660 670 680 690 700
SYRNASSLDS LHYFAAELKP ANLPVTQPFT VGDNKTYNGY WNPPLSPLKS
710 720 730 740 750
YSIYFQALSK ANGETKINCV RLATKGASTQ NSNTVEPEKQ VDNTVKMAGV
760 770 780 790 800
IAGLLMFIII LLGVMLTIKR RKLAKKQKET QSGAQREMGP VASADKPTTK
810 820 830 840 850
LSASRNDEGF SSSSQDVNGF TDGSRGELSQ PTLTIQTHPY RTCDPVEMSY
860 870 880 890 900
PRDQFQPAIR VADLLQHITQ MKRGQGYGFK EEYEALPEGQ TASWDTAKED
910 920 930 940 950
ENRNKNRYGN IISYDHSRVR LLVLDGDPHS DYINANYIDG YHRPRHYIAT
960 970 980 990 1000
QGPMQETVKD FWRMIWQENS ASIVMVTNLV EVGRVKCVRY WPDDTEVYGD
1010 1020 1030 1040 1050
IKVTLIETEP LAEYVIRTFT VQKKGYHEIR ELRLFHFTSW PDHGVPCYAT
1060 1070 1080 1090 1100
GLLGFVRQVK FLNPPEAGPI VVHCSAGAGR TGCFIAIDTM LDMAENEGVV
1110 1120 1130 1140 1150
DIFNCVRELR AQRVNLVQTE EQYVFVHDAI LEACLCGNTA IPVCEFRSLY
1160 1170 1180 1190 1200
YNISRLDPQT NSSQIKDEFQ TLNIVTPRVR PEDCSIGLLP RNHDKNRSMD
1210 1220 1230 1240 1250
VLPLDRCLPF LISVDGESSN YINAALMDSH KQPAAFVVTQ HPLPNTVADF
1260 1270 1280 1290 1300
WRLVFDYNCS SVVMLNEMDT AQFCMQYWPE KTSGCYGPIQ VEFVSADIDE
1310 1320 1330 1340 1350
DIIHRIFRIC NMARPQDGYR IVQHLQYIGW PAYRDTPPSK RSLLKVVRRL
1360 1370 1380 1390 1400
EKWQEQYDGR EGRTVVHCLN GGGRSGTFCA ICSVCEMIQQ QNIIDVFHIV
1410 1420 1430
KTLRNNKSNM VETLEQYKFV YEVALEYLSS F
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO14522 | PTPRT_HUMAN | Receptor-type tyrosine-protein phos... | PTPRT KIAA0283 | 1,441 | Annotation score: | ||
B1AJR9 | B1AJR9_HUMAN | Protein-tyrosine-phosphatase | PTPRT | 1,451 | Annotation score: | ||
B1AJR8 | B1AJR8_HUMAN | Protein-tyrosine-phosphatase | PTPRT | 1,450 | Annotation score: | ||
A0A075B6H0 | A0A075B6H0_HUMAN | Protein-tyrosine-phosphatase | PTPRT | 1,460 | Annotation score: | ||
B1AJR6 | B1AJR6_HUMAN | Protein-tyrosine-phosphatase | PTPRT | 1,440 | Annotation score: | ||
A0A087WY22 | A0A087WY22_HUMAN | Protein-tyrosine-phosphatase | PTPRT | 1,059 | Annotation score: | ||
A0A087X1X2 | A0A087X1X2_HUMAN | Protein-tyrosine-phosphatase | PTPRT | 1,076 | Annotation score: | ||
A0A087WWD6 | A0A087WWD6_HUMAN | Receptor-type tyrosine-protein phos... | PTPRT | 313 | Annotation score: | ||
A0A087X1J1 | A0A087X1J1_HUMAN | Receptor-type tyrosine-protein phos... | PTPRT | 47 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL022239 Genomic DNA No translation available. AL024473 Genomic DNA No translation available. AL035459 Genomic DNA No translation available. AL049812 Genomic DNA No translation available. AL109826 Genomic DNA No translation available. KF456906 Genomic DNA No translation available. KF456910 Genomic DNA No translation available. Z93942 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000373201; ENSP00000362297; ENSG00000196090 |
UCSCi | uc061xcc.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL022239 Genomic DNA No translation available. AL024473 Genomic DNA No translation available. AL035459 Genomic DNA No translation available. AL049812 Genomic DNA No translation available. AL109826 Genomic DNA No translation available. KF456906 Genomic DNA No translation available. KF456910 Genomic DNA No translation available. Z93942 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | B1AJS0 |
PRIDEi | B1AJS0 |
ProteomicsDBi | 2985 |
Protocols and materials databases
Antibodypediai | 2780, 107 antibodies |
Genome annotation databases
Ensembli | ENST00000373201; ENSP00000362297; ENSG00000196090 |
UCSCi | uc061xcc.1, human |
Organism-specific databases
HGNCi | HGNC:9682, PTPRT |
OpenTargetsi | ENSG00000196090 |
VEuPathDBi | HostDB:ENSG00000196090.12 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155326 |
OrthoDBi | 411281at2759 |
Miscellaneous databases
ChiTaRSi | PTPRT, human |
Gene expression databases
Bgeei | ENSG00000196090, Expressed in middle temporal gyrus and 108 other tissues |
ExpressionAtlasi | B1AJS0, baseline and differential |
Family and domain databases
CDDi | cd00063, FN3, 3 hits cd06263, MAM, 1 hit |
Gene3Di | 2.60.40.10, 4 hits 3.90.190.10, 2 hits |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR000998, MAM_dom IPR029021, Prot-tyrosine_phosphatase-like IPR000242, PTPase_domain IPR041201, PTPRJ_TM IPR016130, Tyr_Pase_AS IPR003595, Tyr_Pase_cat IPR000387, TYR_PHOSPHATASE_dom |
Pfami | View protein in Pfam PF00041, fn3, 2 hits PF00629, MAM, 1 hit PF18861, PTP_tm, 1 hit PF00102, Y_phosphatase, 2 hits |
PRINTSi | PR00020, MAMDOMAIN PR00700, PRTYPHPHTASE |
SMARTi | View protein in SMART SM00060, FN3, 3 hits SM00137, MAM, 1 hit SM00194, PTPc, 2 hits SM00404, PTPc_motif, 2 hits |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF49265, SSF49265, 2 hits SSF49899, SSF49899, 1 hit SSF52799, SSF52799, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 3 hits PS50835, IG_LIKE, 1 hit PS00740, MAM_1, 1 hit PS50060, MAM_2, 1 hit PS00383, TYR_PHOSPHATASE_1, 2 hits PS50056, TYR_PHOSPHATASE_2, 2 hits PS50055, TYR_PHOSPHATASE_PTP, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B1AJS0_HUMAN | |
Accessioni | B1AJS0Primary (citable) accession number: B1AJS0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 8, 2008 |
Last sequence update: | April 8, 2008 | |
Last modified: | February 10, 2021 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |