UniProtKB - B0ZBE0 (B0ZBE0_HUMAN)
Protein
Alpha-1D adrenergic receptor
Gene
ADRA1D
Organism
Homo sapiens (Human)
Status
Functioni
This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.ARBA annotation
GO - Molecular functioni
- alpha1-adrenergic receptor activity Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotationARBA annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-1D adrenergic receptorARBA annotationAlternative name(s): Alpha-1D adrenoreceptorARBA annotation |
Gene namesi | Name:ADRA1DImported ORF Names:hCG_1646223Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000171873.7 |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 99 – 121 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 133 – 152 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 172 – 192 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 213 – 234 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 254 – 279 | HelicalSequence analysisAdd BLAST | 26 | |
Transmembranei | 346 – 366 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 386 – 405 | HelicalSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
Cell membraneARBA annotation, MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000171873, Expressed in thoracic aorta and 114 other tissues |
ExpressionAtlasi | B0ZBE0, baseline and differential |
Interactioni
Subunit structurei
Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.
ARBA annotationChemistry databases
BindingDBi | B0ZBE0 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 113 – 402 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 290 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 77 | DisorderedSequence analysisAdd BLAST | 77 | |
Regioni | 444 – 488 | DisorderedSequence analysisAdd BLAST | 45 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 463 – 479 | Pro-richSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
HOGENOMi | CLU_009579_11_6_1 |
OMAi | GATCQAY |
OrthoDBi | 1095345at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR002233, ADR_fam IPR000363, ADRA1D_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24248:SF14, PTHR24248:SF14, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01103, ADRENERGICR PR00240, ADRENRGCA1DR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
B0ZBE0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTFRDLLSVS FEGPRPDSSA GGSSAGGGGG SAGGAAPSEG PAVGGVPGGA
60 70 80 90 100
GGGGGVVGAG SGEDNRSSAG EPGSAGAGGD VNGTAAVGGL VVSAQGVGVG
110 120 130 140 150
VFLAAFILMA VAGNLLVILS VACNRHLQTV TNYFIVNLAV ADLLLSATVL
160 170 180 190 200
PFSATMEVLG FWAFGRAFCD VWAAVDVLCC TASILSLCTI SVDRYVGVRH
210 220 230 240 250
SLKYPAIMTE RKAAAILALL WVVALVVSVG PLLGWKEPVP PDERFCGITE
260 270 280 290 300
EAGYAVFSSV CSFYLPMAVI VVMYCRVYVV ARSTTRSLEA GVKRERGKAS
310 320 330 340 350
EVVLRIHCRG AATGADGAHG MRSAKGHTFR SSLSVRLLKF SREKKAAKTL
360 370 380 390 400
AIVVGVFVLC WFPFFFVLPL GSLFPQLKPS EGVFKVIFWL GYFNSCVNPL
410 420 430 440 450
IYPCSSREFK RAFLRLLRCQ CRRRRRRRPL WRVYGHHWRA STSGLRQDCA
460 470 480 490 500
PSSGDAPPGA PLALTALPDP DPEPPGTPEM QAPVASRRKP PSAFREWRLL
510 520 530 540 550
GPFRRPTTQL RAKVSSLSHK IRAGGAQRAE AACAQRSEVE AVSLGVPHEV
560 570
AEGATCQAYE LADYSNLRET DI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU326302 Genomic DNA Translation: ACA05908.1 CH471133 Genomic DNA Translation: EAX10455.1 |
RefSeqi | NP_000669.1, NM_000678.3 |
Genome annotation databases
GeneIDi | 146 |
KEGGi | hsa:146 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU326302 Genomic DNA Translation: ACA05908.1 CH471133 Genomic DNA Translation: EAX10455.1 |
RefSeqi | NP_000669.1, NM_000678.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Chemistry databases
BindingDBi | B0ZBE0 |
Protein family/group databases
GPCRDBi | Search... |
Protocols and materials databases
Antibodypediai | 7918, 153 antibodies |
DNASUi | 146 |
Genome annotation databases
GeneIDi | 146 |
KEGGi | hsa:146 |
Organism-specific databases
CTDi | 146 |
EuPathDBi | HostDB:ENSG00000171873.7 |
PharmGKBi | PA24597 |
Phylogenomic databases
HOGENOMi | CLU_009579_11_6_1 |
OMAi | GATCQAY |
OrthoDBi | 1095345at2759 |
Miscellaneous databases
BioGRID-ORCSi | 146, 6 hits in 845 CRISPR screens |
ChiTaRSi | ADRA1D, human |
GenomeRNAii | 146 |
Gene expression databases
Bgeei | ENSG00000171873, Expressed in thoracic aorta and 114 other tissues |
ExpressionAtlasi | B0ZBE0, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR002233, ADR_fam IPR000363, ADRA1D_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24248:SF14, PTHR24248:SF14, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01103, ADRENERGICR PR00240, ADRENRGCA1DR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B0ZBE0_HUMAN | |
Accessioni | B0ZBE0Primary (citable) accession number: B0ZBE0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 8, 2008 |
Last sequence update: | April 8, 2008 | |
Last modified: | December 2, 2020 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |