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UniProtKB - B0YJ76 (B0YJ76_HUMAN)
Protein
Dihydrofolate reductase
Gene
DYR
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:1.5.1.3ARBA annotation
: tetrahydrofolate biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate.ARBA annotation This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.
GO - Molecular functioni
- dihydrofolate reductase activity Source: UniProtKB-EC
- NADP binding Source: InterPro
GO - Biological processi
- glycine biosynthetic process Source: InterPro
- one-carbon metabolic process Source: UniProtKB-KW
- response to methotrexate Source: UniProtKB-KW
- tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | OxidoreductaseImportedARBA annotation |
Biological process | Methotrexate resistanceARBA annotation, One-carbon metabolismARBA annotation |
Ligand | NADPARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00077;UER00158 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:DYRImported Synonyms:DHFRImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000228716 |
Expressioni
Gene expression databases
Bgeei | ENSG00000228716, Expressed in buccal mucosa cell and 248 other tissues |
Interactioni
Binary interactionsi
B0YJ76
With | #Exp. | IntAct |
---|---|---|
GKAP1 [Q5VSY0] | 3 | EBI-10175413,EBI-743722 |
Protein-protein interaction databases
IntActi | B0YJ76, 1 interactor |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 185 | DHFRInterPro annotationAdd BLAST | 182 |
Sequence similaritiesi
Belongs to the dihydrofolate reductase family.UniRule annotation
Phylogenomic databases
HOGENOMi | CLU_043966_2_3_1 |
OMAi | RDNQLPW |
OrthoDBi | 1489621at2759 |
Family and domain databases
CDDi | cd00209, DHFR, 1 hit |
Gene3Di | 3.40.430.10, 1 hit |
InterProi | View protein in InterPro IPR012259, DHFR IPR024072, DHFR-like_dom_sf IPR017925, DHFR_CS IPR001796, DHFR_dom |
PANTHERi | PTHR48069, PTHR48069, 1 hit |
Pfami | View protein in Pfam PF00186, DHFR_1, 1 hit |
SUPFAMi | SSF53597, SSF53597, 1 hit |
PROSITEi | View protein in PROSITE PS00075, DHFR_1, 1 hit PS51330, DHFR_2, 1 hit |
i Sequence
Sequence statusi: Complete.
B0YJ76-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVGSLNCIVA VSQNMGIGKN GDLPWPPLRN EFRYFQRMTT TSSVEGKQNL
60 70 80 90 100
VIMGKKTWFS IPEKNRPLKG RINLVLSREL KEPPQGAHFL SRSLDDALKL
110 120 130 140 150
TEQPELANKV DMVWIVGGSS VYKEAMNHPG HLKLFVTRIM QDFESDTFFP
160 170 180
EIDLEKYKLL PEYPGVLSDV QEEKGIKYKF EVYEKND
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU145592 mRNA Translation: ABX57718.1 EF445014 Genomic DNA Translation: ACA06052.1 AK312642 mRNA Translation: BAG35526.1 |
RefSeqi | NP_000782.1, NM_000791.3 |
Genome annotation databases
GeneIDi | 1719 |
KEGGi | hsa:1719 |
MANE-Selecti | ENST00000439211.7; ENSP00000396308.2; NM_000791.4; NP_000782.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU145592 mRNA Translation: ABX57718.1 EF445014 Genomic DNA Translation: ACA06052.1 AK312642 mRNA Translation: BAG35526.1 |
RefSeqi | NP_000782.1, NM_000791.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | B0YJ76, 1 interactor |
Protocols and materials databases
Antibodypediai | 24646, 309 antibodies from 32 providers |
DNASUi | 1719 |
Genome annotation databases
GeneIDi | 1719 |
KEGGi | hsa:1719 |
MANE-Selecti | ENST00000439211.7; ENSP00000396308.2; NM_000791.4; NP_000782.1 |
Organism-specific databases
CTDi | 1719 |
PharmGKBi | PA143 |
VEuPathDBi | HostDB:ENSG00000228716 |
Phylogenomic databases
HOGENOMi | CLU_043966_2_3_1 |
OMAi | RDNQLPW |
OrthoDBi | 1489621at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00077;UER00158 |
Miscellaneous databases
BioGRID-ORCSi | 1719, 576 hits in 1053 CRISPR screens |
ChiTaRSi | DHFR, human |
GenomeRNAii | 1719 |
Gene expression databases
Bgeei | ENSG00000228716, Expressed in buccal mucosa cell and 248 other tissues |
Family and domain databases
CDDi | cd00209, DHFR, 1 hit |
Gene3Di | 3.40.430.10, 1 hit |
InterProi | View protein in InterPro IPR012259, DHFR IPR024072, DHFR-like_dom_sf IPR017925, DHFR_CS IPR001796, DHFR_dom |
PANTHERi | PTHR48069, PTHR48069, 1 hit |
Pfami | View protein in Pfam PF00186, DHFR_1, 1 hit |
SUPFAMi | SSF53597, SSF53597, 1 hit |
PROSITEi | View protein in PROSITE PS00075, DHFR_1, 1 hit PS51330, DHFR_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B0YJ76_HUMAN | |
Accessioni | B0YJ76Primary (citable) accession number: B0YJ76 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 8, 2008 |
Last sequence update: | April 8, 2008 | |
Last modified: | January 19, 2022 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |