UniProtKB - B0YJ32 (B0YJ32_HUMAN)
Protein
Submitted name:
Laminin alpha-3 chain variant 1
Gene
LAMA3
Organism
Homo sapiens (Human)
Status
Functioni
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.ARBA annotation
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- signaling receptor binding Source: InterPro
GO - Biological processi
- cell adhesion Source: InterPro
- regulation of cell adhesion Source: InterPro
- regulation of cell migration Source: InterPro
- regulation of embryonic development Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Laminin alpha-3 chain variant 1Imported |
Gene namesi | Name:LAMA3Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Extracellular region or secreted
- basement membrane ARBA annotation
Other locations
- Membrane ARBA annotation
Extracellular region or secreted
- basement membrane Source: UniProtKB-SubCell
Other locations
- membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Basement membraneARBA annotation, Extracellular matrix, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 36 | Sequence analysisAdd BLAST | 36 | |
ChainiPRO_5002758540 | 37 – 3335 | Sequence analysisAdd BLAST | 3299 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 321 ↔ 330 | PROSITE-ProRule annotation | ||
Disulfide bondi | 393 ↔ 402 | PROSITE-ProRule annotation | ||
Disulfide bondi | 445 ↔ 454 | PROSITE-ProRule annotation | ||
Disulfide bondi | 493 ↔ 505 | PROSITE-ProRule annotation | ||
Disulfide bondi | 513 ↔ 522 | PROSITE-ProRule annotation | ||
Disulfide bondi | 538 ↔ 550 | PROSITE-ProRule annotation | ||
Disulfide bondi | 540 ↔ 557 | PROSITE-ProRule annotation | ||
Disulfide bondi | 559 ↔ 568 | PROSITE-ProRule annotation | ||
Disulfide bondi | 603 ↔ 612 | PROSITE-ProRule annotation | ||
Disulfide bondi | 656 ↔ 665 | PROSITE-ProRule annotation | ||
Disulfide bondi | 686 ↔ 698 | PROSITE-ProRule annotation | ||
Disulfide bondi | 688 ↔ 705 | PROSITE-ProRule annotation | ||
Disulfide bondi | 707 ↔ 716 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1268 ↔ 1280 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1270 ↔ 1287 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1289 ↔ 1298 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1330 ↔ 1339 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1382 ↔ 1391 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1407 ↔ 1419 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1409 ↔ 1426 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1428 ↔ 1437 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1708 ↔ 1717 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1736 ↔ 1748 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1759 ↔ 1768 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotationProteomic databases
PeptideAtlasi | B0YJ32 |
PRIDEi | B0YJ32 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 43 – 298 | Laminin N-terminalInterPro annotationAdd BLAST | 256 | |
Domaini | 299 – 355 | Laminin EGF-likeInterPro annotationAdd BLAST | 57 | |
Domaini | 356 – 425 | Laminin EGF-likeInterPro annotationAdd BLAST | 70 | |
Domaini | 426 – 469 | Laminin EGF-likeInterPro annotationAdd BLAST | 44 | |
Domaini | 493 – 537 | Laminin EGF-likeInterPro annotationAdd BLAST | 45 | |
Domaini | 538 – 590 | Laminin EGF-likeInterPro annotationAdd BLAST | 53 | |
Domaini | 592 – 632 | Laminin EGF-likeInterPro annotationAdd BLAST | 41 | |
Domaini | 633 – 685 | Laminin EGF-likeInterPro annotationAdd BLAST | 53 | |
Domaini | 686 – 730 | Laminin EGF-likeInterPro annotationAdd BLAST | 45 | |
Domaini | 1268 – 1313 | Laminin EGF-likeInterPro annotationAdd BLAST | 46 | |
Domaini | 1314 – 1357 | Laminin EGF-likeInterPro annotationAdd BLAST | 44 | |
Domaini | 1358 – 1406 | Laminin EGF-likeInterPro annotationAdd BLAST | 49 | |
Domaini | 1407 – 1457 | Laminin EGF-likeInterPro annotationAdd BLAST | 51 | |
Domaini | 1478 – 1655 | Laminin IV type AInterPro annotationAdd BLAST | 178 | |
Domaini | 1689 – 1735 | Laminin EGF-likeInterPro annotationAdd BLAST | 47 | |
Domaini | 1736 – 1788 | Laminin EGF-likeInterPro annotationAdd BLAST | 53 | |
Domaini | 2392 – 2593 | LAM_G_DOMAINInterPro annotationAdd BLAST | 202 | |
Domaini | 2600 – 2762 | LAM_G_DOMAINInterPro annotationAdd BLAST | 163 | |
Domaini | 2769 – 2929 | LAM_G_DOMAINInterPro annotationAdd BLAST | 161 | |
Domaini | 2988 – 3152 | LAM_G_DOMAINInterPro annotationAdd BLAST | 165 | |
Domaini | 3159 – 3332 | LAM_G_DOMAINInterPro annotationAdd BLAST | 174 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1855 – 1938 | Sequence analysisAdd BLAST | 84 | |
Coiled coili | 2023 – 2064 | Sequence analysisAdd BLAST | 42 | |
Coiled coili | 2100 – 2134 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 2137 – 2171 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 2327 – 2347 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 2365 – 2385 | Sequence analysisAdd BLAST | 21 |
Keywords - Domaini
Coiled coilSequence analysisARBA annotation, Laminin EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, SignalSequence analysisFamily and domain databases
Gene3Di | 2.60.120.1490, 1 hit |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR000742, EGF-like_dom IPR009254, Laminin_aI IPR010307, Laminin_dom_II IPR002049, Laminin_EGF IPR001791, Laminin_G IPR000034, Laminin_IV IPR008211, Laminin_N IPR038684, Laminin_N_sf |
Pfami | View protein in Pfam PF00052, Laminin_B, 1 hit PF00053, Laminin_EGF, 12 hits PF00054, Laminin_G_1, 1 hit PF02210, Laminin_G_2, 4 hits PF06008, Laminin_I, 1 hit PF06009, Laminin_II, 1 hit PF00055, Laminin_N, 1 hit |
SMARTi | View protein in SMART SM00181, EGF, 8 hits SM00180, EGF_Lam, 14 hits SM00281, LamB, 1 hit SM00282, LamG, 5 hits SM00136, LamNT, 1 hit |
SUPFAMi | SSF49899, SSF49899, 5 hits |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 1 hit PS01248, EGF_LAM_1, 6 hits PS50027, EGF_LAM_2, 14 hits PS50025, LAM_G_DOMAIN, 5 hits PS51115, LAMININ_IVA, 1 hit PS51117, LAMININ_NTER, 1 hit |
i Sequence
Sequence statusi: Complete.
B0YJ32-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAAARPRGR ALGPVLPPTP LLLLVLRVLP ACGATARDPG AAAGLSLHPT
60 70 80 90 100
YFNLAEAARI WATATCGERG PGEGRPQPEL YCKLVGGPTA PGSGHTIQGQ
110 120 130 140 150
FCDYCNSEDP RKAHPVTNAI DGSERWWQSP PLSSGTQYNR VNLTLDLGQL
160 170 180 190 200
FHVAYILIKF ANSPRPDLWV LERSVDFGST YSPWQYFAHS KVDCLKEFGR
210 220 230 240 250
EANMAVTRDD DVLCVTEYSR IVPLENGEVV VSLINGRPGA KNFTFSHTLR
260 270 280 290 300
EFTKATNIRL RFLRTNTLLG HLISKAQRDP TVTRRYYYSI KDISIGGQCV
310 320 330 340 350
CNGHAEVCNI NNPEKLFRCE CQHHTCGETC DRCCTGYNQR RWRPAAWEQS
360 370 380 390 400
HECEACNCHG HASNCYYDPD VERQQASLNT QGIYAGGGVC INCQHNTAGV
410 420 430 440 450
NCEQCAKGYY RPYGVPVDAP DGCIPCSCDP EHADGCEQGS GRCHCKPNFH
460 470 480 490 500
GDNCEKCAIG YYNFPFCLRI PIFPVSTPSS EDPVAGDIKG NWCDCNLEGV
510 520 530 540 550
LPEICDAHGR CLCRPGVEGP RCDTCRSGFY SFPICQACWC SALGSYQMPC
560 570 580 590 600
SSVTGQCECR PGVTGQRCDR CLSGAYDFPH CQGSSSACDP AGTINSNLGY
610 620 630 640 650
CQCKLHVEGP TCSRCKLLYW NLDKENPSGC SECKCHKAGT VSGTGECRQG
660 670 680 690 700
DGDCHCKSHV GGDSCDTCED GYFALEKSNY FGCQGCQCDI GGALSSMCSG
710 720 730 740 750
PSGVCQCREH VVGKVCQRPE NNYYFPDLHH MKYEIEDGST PNGRDLRFGF
760 770 780 790 800
DPLAFPEFSW RGYAQMTSVQ NDVRITLNVG KSSGSLFRVI LRYVNPGTEA
810 820 830 840 850
VSGHITIYPS WGAAQSKEII FLPSKEPAFV TVPGNGFADP FSITPGIWVA
860 870 880 890 900
CIKAEGVLLD YLVLLPRDYY EASVLQLPVT EPCAYAGPPQ ENCLLYQHLP
910 920 930 940 950
VTRFPCTLAC EARHFLLDGE PRPVAVRQPT PAHPVMVDLS GREVELHLRL
960 970 980 990 1000
RIPQVGHYVV VVEYSTEAAQ LFVVDVNVKS SGSVLAGQVN IYSCNYSVLC
1010 1020 1030 1040 1050
RSAVIDHMSR IAMYELLADA DIQLKGHMAR FLLHQVCIIP IEEFSAEYVR
1060 1070 1080 1090 1100
PQVHCIASYG RFVNQSATCV SLAHETPPTA LILDVLSGRP FPHLPQQSSP
1110 1120 1130 1140 1150
SVDVLPGVTL KAPQNQVTLR GRVPHLGRYV FVIHFYQAAH PTFPAQVSVD
1160 1170 1180 1190 1200
GGWPRAGSFH ASFCPHVLGC RDQVIAEGQI EFDISEPEVA ATVKVPEGKS
1210 1220 1230 1240 1250
LVLVRVLVVP AENYDYQILH KKSMDKSLEF ITNCGKNSFY LDPQTASRFC
1260 1270 1280 1290 1300
KNSARSLVAF YHKGALPCEC HPTGATGPHC SPEGGQCPCQ PNVIGRQCTR
1310 1320 1330 1340 1350
CATGHYGFPR CKPCSCGRRL CEEMTGQCRC PPRTVRPQCE VCETHSFSFH
1360 1370 1380 1390 1400
PMAGCEGCNC SRRGTIEAAM PECDRDSGQC RCKPRITGRQ CDRCASGFYR
1410 1420 1430 1440 1450
FPECVPCNCN RDGTEPGVCD PGTGACLCKE NVEGTECNVC REGSFHLDPA
1460 1470 1480 1490 1500
NLKGCTSCFC FGVNNQCHSS HKRRTKFVDM LGWHLETADR VDIPVSFNPG
1510 1520 1530 1540 1550
SNSMVADLQE LPATIHSASW VAPTSYLGDK VSSYGGYLTY QAKSFGLPGD
1560 1570 1580 1590 1600
MVLLEKKPDV QLTGQHMSII YEETNTPRPD RLHHGRVHVV EGNFRHASSR
1610 1620 1630 1640 1650
APVSREELMT VLSRLADVRI QGLYFTETQR LTLSEVGLEE ASDTGSGRIA
1660 1670 1680 1690 1700
LAVEICACPP AYAGDSCQGC SPGYYRDHKG LYTGRCVPCN CNGHSNQCQD
1710 1720 1730 1740 1750
GSGICVNCQH NTAGEHCERC QEGYYGNAVH GSCRACPCPH TNSFATGCVV
1760 1770 1780 1790 1800
NGGDVRCSCK AGYTGTQCER CAPGYFGNPQ KFGGSCQPCS CNSNGQLGSC
1810 1820 1830 1840 1850
HPLTGDCINQ EPKDSSPAEE CDDCDSCVMT LLNDLATMGE QLRLVKSQLQ
1860 1870 1880 1890 1900
GLSASAGLLE QMRHMETQAK DLRNQLLNYR SAISNHGSKI EGLERELTDL
1910 1920 1930 1940 1950
NQEFETLQEK AQVNSRKAQT LNNNVNRATQ SAKELDVKIK NVIRNVHILL
1960 1970 1980 1990 2000
KQISGTDGEG NNVPSGDFSR EWAEAQRMMR ELRNRNFGKH LREAEADKRE
2010 2020 2030 2040 2050
SQLLLNRIRT WQKTHQGENN GLANSIRDSL NEYEAKLSDL RARLQEAAAQ
2060 2070 2080 2090 2100
AKQANGLNQE NERALGAIQR QVKEINSLQS DFTKYLTTAD SSLLQTNIAL
2110 2120 2130 2140 2150
QLMEKSQKEY EKLAASLNEA RQELSDKVRE LSRSAGKTSL VEEAEKHARS
2160 2170 2180 2190 2200
LQELAKQLEE IKRNASGDEL VRCAVDAATA YENILNAIKA AEDAANRAAS
2210 2220 2230 2240 2250
ASESALQTVI KEDLPRKAKT LSSNSDKLLN EAKMTQKKLK QEVSPALNNL
2260 2270 2280 2290 2300
QQTLNIVTVQ KEVIDTNLTT LRDGLHGIQR GDIDAMISSA KSMVRKANDI
2310 2320 2330 2340 2350
TDEVLDGLNP IQTDVERIKD TYGRTQNEDF KKALTDADNS VNKLTNKLPD
2360 2370 2380 2390 2400
LWRKIESINQ QLLPLGNISD NMDRIRELIQ QARDAASKVA VPMRFNGKSG
2410 2420 2430 2440 2450
VEVRLPNDLE DLKGYTSLSL FLQRPNSREN GGTENMFVMY LGNKDASRDY
2460 2470 2480 2490 2500
IGMAVVDGQL TCVYNLGDRE AELQVDQILT KSETKEAVMD RVKFQRIYQF
2510 2520 2530 2540 2550
ARLNYTKGAT SSKPETPGVY DMDGRNSNTL LNLDPENVVF YVGGYPPDFK
2560 2570 2580 2590 2600
LPSRLSFPPY KGCIELDDLN ENVLSLYNFK KTFNLNTTEV EPCRRRKEES
2610 2620 2630 2640 2650
DKNYFEGTGY ARVPTQPHAP IPTFGQTIQT TVDRGLLFFA ENGDRFISLN
2660 2670 2680 2690 2700
IEDGKLMVRY KLNSELPKER GVGDAINNGR DHSIQIKIGK LQKRMWINVD
2710 2720 2730 2740 2750
VQNTIIDGEV FDFSTYYLGG IPIAIRERFN ISTPAFRGCM KNLKKTSGVV
2760 2770 2780 2790 2800
RLNDTVGVTK KCSEDWKLVR SASFSRGGQL SFTDLGLPPT DHLQASFGFQ
2810 2820 2830 2840 2850
TFQPSGILLD HQTWTRNLQV TLEDGYIELS TSDSGSPIFK SPQTYMDGLL
2860 2870 2880 2890 2900
HYVSVISDNS GLRLLIDDQL LRNSKRLKHI SSSRQSLRLG GSNFEGCISN
2910 2920 2930 2940 2950
VFVQRLSLSP EVLDLTSNSL KRDVSLGGCS LNKPPFLMLL KGSTRFNKTK
2960 2970 2980 2990 3000
TFRINQLLQD TPVASPRSVK VWQDACSPLP KTQANHGALQ FGDIPTSHLL
3010 3020 3030 3040 3050
FKLPQELLKP RSQFAVDMQT TSSRGLVFHT GTKNSFMALY LSKGRLVFAL
3060 3070 3080 3090 3100
GTDGKKLRIK SKEKCNDGKW HTVVFGHDGE KGRLVVDGLR AREGSLPGNS
3110 3120 3130 3140 3150
TISIRAPVYL GSPPSGKPKS LPTNSFVGCL KNFQLDSKPL YTPSSSFGVS
3160 3170 3180 3190 3200
SCLGGPLEKG IYFSEEGGHV VLAHSVLLGP EFKLVFSIRP RSLTGILIHI
3210 3220 3230 3240 3250
GSQPGKHLCV YLEAGKVTAS MDSGAGGTST SVTPKQSLCD GQWHSVAVTI
3260 3270 3280 3290 3300
KQHILHLELD TDSSYTAGQI PFPPASTQEP LHLGGAPANL TTLRIPVWKS
3310 3320 3330
FFGCLRNIHV NHIPVPVTEA LEVQGPVSLN GCPDQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF444992 Genomic DNA Translation: ACA06010.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF444992 Genomic DNA Translation: ACA06010.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | B0YJ32 |
PRIDEi | B0YJ32 |
Miscellaneous databases
ChiTaRSi | LAMA3, human |
Family and domain databases
Gene3Di | 2.60.120.1490, 1 hit |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR000742, EGF-like_dom IPR009254, Laminin_aI IPR010307, Laminin_dom_II IPR002049, Laminin_EGF IPR001791, Laminin_G IPR000034, Laminin_IV IPR008211, Laminin_N IPR038684, Laminin_N_sf |
Pfami | View protein in Pfam PF00052, Laminin_B, 1 hit PF00053, Laminin_EGF, 12 hits PF00054, Laminin_G_1, 1 hit PF02210, Laminin_G_2, 4 hits PF06008, Laminin_I, 1 hit PF06009, Laminin_II, 1 hit PF00055, Laminin_N, 1 hit |
SMARTi | View protein in SMART SM00181, EGF, 8 hits SM00180, EGF_Lam, 14 hits SM00281, LamB, 1 hit SM00282, LamG, 5 hits SM00136, LamNT, 1 hit |
SUPFAMi | SSF49899, SSF49899, 5 hits |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 1 hit PS01248, EGF_LAM_1, 6 hits PS50027, EGF_LAM_2, 14 hits PS50025, LAM_G_DOMAIN, 5 hits PS51115, LAMININ_IVA, 1 hit PS51117, LAMININ_NTER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B0YJ32_HUMAN | |
Accessioni | B0YJ32Primary (citable) accession number: B0YJ32 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 8, 2008 |
Last sequence update: | April 8, 2008 | |
Last modified: | October 7, 2020 | |
This is version 84 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |