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UniProtKB - B0Y581 (M2DH_ASPFC)
Protein
Mannitol 2-dehydrogenase
Gene
AFUB_071700
Organism
Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Status
Functioni
Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway.
By similarityCatalytic activityi
- EC:1.1.1.67
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 37 – 48 | NADBy similarityAdd BLAST | 12 |
GO - Molecular functioni
- mannitol 2-dehydrogenase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:AFUB_071700 |
Organismi | Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus) |
Taxonomic identifieri | 451804 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus › Aspergillus subgen. Fumigati › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | FungiDB:AFUB_071700 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000371539 | 1 – 502 | Mannitol 2-dehydrogenaseAdd BLAST | 502 |
Interactioni
Subunit structurei
Monomer.
By similarityFamily & Domainsi
Sequence similaritiesi
Belongs to the mannitol dehydrogenase family.Curated
Phylogenomic databases
HOGENOMi | CLU_027324_0_1_1 |
PhylomeDBi | B0Y581 |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR000669, Mannitol_DH IPR013118, Mannitol_DH_C IPR013131, Mannitol_DH_N IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF01232, Mannitol_dh, 1 hit PF08125, Mannitol_dh_C, 1 hit |
PRINTSi | PR00084, MTLDHDRGNASE |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
i Sequence
Sequence statusi: Complete.
B0Y581-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPLKLNSRN LSQIAAAGGA LVKIPTYQRG RAVKEGIVHI GVGGFHRAHL
60 70 80 90 100
AVYIDQLMQK HGVNDYAICG VGLQPFDSAM RDALASQDHL YTLIERSAKG
110 120 130 140 150
SFAHVIGSIN SYLFAPDNRE AVIAKMAHPD TKIVSLTITE SGYYYNENTH
160 170 180 190 200
ELQSEHPDIQ FDLDPANEKA PRTTFGFLYA GLTRRYQQGL KPFTVMSCDN
210 220 230 240 250
MQKNGSITRH MLESFARLRN PEVAEWIAEE GAFPNAMVDR ITPQTSETDK
260 270 280 290 300
TALAEKFGIV DSWPVVTEPF TQWVIEDQFS DGRPPFEKVG VQVVKDVHAV
310 320 330 340 350
EQFEKHKLRL LNGSHSALGY PGQLAGFQYV HEVMANPLFR KFVWQMMQEE
360 370 380 390 400
VKPLLPEIPG VDIDEYCNTL IERFTNPTIM DQLPRICLNA SGKIPQFIMP
410 420 430 440 450
SIAEAIWETG PFRRLCFVAA AWFHYIKGVD DRGKPFEVVD PMREELQAKA
460 470 480 490 500
RAGGNDPSEL LSIKSLFGDD LRNDERFLRE ITTAMNDIAR DGIMKTLPKY
IN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DS499598 Genomic DNA Translation: EDP50830.1 |
Genome annotation databases
EnsemblFungii | EDP50830; EDP50830; AFUB_071700 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DS499598 Genomic DNA Translation: EDP50830.1 |
3D structure databases
AlphaFoldDBi | B0Y581 |
SMRi | B0Y581 |
ModBasei | Search... |
Genome annotation databases
EnsemblFungii | EDP50830; EDP50830; AFUB_071700 |
Organism-specific databases
VEuPathDBi | FungiDB:AFUB_071700 |
Phylogenomic databases
HOGENOMi | CLU_027324_0_1_1 |
PhylomeDBi | B0Y581 |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR000669, Mannitol_DH IPR013118, Mannitol_DH_C IPR013131, Mannitol_DH_N IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF01232, Mannitol_dh, 1 hit PF08125, Mannitol_dh_C, 1 hit |
PRINTSi | PR00084, MTLDHDRGNASE |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | M2DH_ASPFC | |
Accessioni | B0Y581Primary (citable) accession number: B0Y581 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 5, 2009 |
Last sequence update: | April 8, 2008 | |
Last modified: | May 25, 2022 | |
This is version 61 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |