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UniProtKB - B0WVS5 (B0WVS5_CULQU)

Entry version 85 (19 Jan 2022)
Sequence version 1 (08 Apr 2008)
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Protein
Submitted name:

Ku P80 DNA helicase

Gene

6043914

Organism
Culex quinquefasciatus (Southern house mosquito) (Culex pungens)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingARBA annotation, HelicaseImportedARBA annotation, Hydrolase
Biological processDNA damage, DNA recombinationARBA annotation, DNA repairARBA annotation
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ku P80 DNA helicaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:6043914Imported
ORF Names:CpipJ_CPIJ011452Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCulex quinquefasciatus (Southern house mosquito) (Culex pungens)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7176 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicoidea › Culicidae › Culicinae › Culicini › Culex › Culex ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002320 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Partially assembled WGS sequence, Unplaced

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		VectorBase:CPIJ011452

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7176.CPIJ011452-PA

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini295 – 432KuInterPro annotationAdd BLAST138

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni550 – 572DisorderedSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ku80 family.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2326, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010975_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		B0WVS5

Identification of Orthologs from Complete Genome Data

More...OMAi		TEHRNLP

Database of Orthologous Groups

More...OrthoDBi		598957at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd00873, KU80, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.240, 1 hit
2.40.290.10, 1 hit
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006164, Ku70/Ku80_beta-barrel_dom
IPR024193, Ku80
IPR005160, Ku_C
IPR036494, Ku_C_sf
IPR005161, Ku_N
IPR014893, Ku_PK_bind
IPR016194, SPOC-like_C_dom_sf
IPR036465, vWFA_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02735, Ku, 1 hit
PF03730, Ku_C, 1 hit
PF03731, Ku_N, 1 hit
PF08785, Ku_PK_bind, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00559, Ku78, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF100939, SSF100939, 1 hit
SSF101420, SSF101420, 1 hit
SSF53300, SSF53300, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B0WVS5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARTKEACIL ILDVGKDTLV KSGKNDLTFF ERAKGCVTKI VQRKIFSKPH 
        60         70         80         90        100
DEVGLVLMGT DDTSNQLNVE CGGYEHIAEA FELGPSNWKM LRILESRIQP 
       110        120        130        140        150
SKVNANWFDA LLVATNFLKV GAQAKKFATL KIILISKLSG VVELEAGELD 
       160        170        180        190        200
SFVDKLTNMP CELNIINDNV EHQAGSDEQE EDGLGFDALG IFSQRGNRSK 
       210        220        230        240        250
EQRKNEKLLA DIVFKSNGAL CNIDSAELLL VHFERKVTRS MPWNCMLTIG 
       260        270        280        290        300
SKLQISTSTY VLISEEKGLS SFKTECVDPN AVVKLKTDHF KNDKLYEPDF 
       310        320        330        340        350
EDLIKGYMYG STVVPYDSQM DFDYKSGEQC LSCLGFTAAG NILEEYLCGT 
       360        370        380        390        400
GTHVVVAKKD CAASEAKLTA LIKAMLELDV VMIATKVYRR DTKPKIQALF 
       410        420        430        440        450
PTFRRRFPCL TMLELVFQEE VALLKFPPLL SNRHKPTDAQ YEAVDKLIDA 
       460        470        480        490        500
MDLMDGLDDE TGSKEAFALH KTLNPIHQHM YRTVAHRAIH PKAPLPAMDE 
       510        520        530        540        550
ELRQLVDVPS KIRERSKEAL EDIKNLFPLK ELKVNAQLKW LQKTAKINVQ 
       560        570        580        590        600
PDGDAAGSSS QPNDGSADEE LDDHRTVVEV GTVTPAEDFA LLLKRGEKFA 
       610        620        630        640        650
TVCTQIQNVI SGLVFKSMTT QYEKVAMAIM IFREEAKLLG PYRFNEWIGE 
       660        670        680        690        700
FKKSLLSRNK QEFWQRVVVQ ERFGLIGAAE SEMSTITANE VEEFYDVGVT 
       710        720 
SKVGSAEDNA DYVDADDLFA NM
Length:722
Mass (Da):80,846
Last modified:April 8, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i003A62ECBA3AB038
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
DS232131 Genomic DNA Translation: EDS35682.1

NCBI Reference Sequences

More...RefSeqi		XP_001861497.1, XM_001861462.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		CPIJ011452-RA; CPIJ011452-PA; CPIJ011452

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6043914

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		cqu:CpipJ_CPIJ011452

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS232131 Genomic DNA Translation: EDS35682.1
RefSeqiXP_001861497.1, XM_001861462.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi7176.CPIJ011452-PA

Genome annotation databases

EnsemblMetazoaiCPIJ011452-RA; CPIJ011452-PA; CPIJ011452
GeneIDi6043914
KEGGicqu:CpipJ_CPIJ011452

Organism-specific databases

VEuPathDBiVectorBase:CPIJ011452

Phylogenomic databases

eggNOGiKOG2326, Eukaryota
HOGENOMiCLU_010975_2_1_1
InParanoidiB0WVS5
OMAiTEHRNLP
OrthoDBi598957at2759

Family and domain databases

CDDicd00873, KU80, 1 hit
Gene3Di1.25.40.240, 1 hit
2.40.290.10, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR006164, Ku70/Ku80_beta-barrel_dom
IPR024193, Ku80
IPR005160, Ku_C
IPR036494, Ku_C_sf
IPR005161, Ku_N
IPR014893, Ku_PK_bind
IPR016194, SPOC-like_C_dom_sf
IPR036465, vWFA_dom_sf
PfamiView protein in Pfam
PF02735, Ku, 1 hit
PF03730, Ku_C, 1 hit
PF03731, Ku_N, 1 hit
PF08785, Ku_PK_bind, 1 hit
SMARTiView protein in SMART
SM00559, Ku78, 1 hit
SUPFAMiSSF100939, SSF100939, 1 hit
SSF101420, SSF101420, 1 hit
SSF53300, SSF53300, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB0WVS5_CULQU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B0WVS5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: January 19, 2022
This is version 85 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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