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Entry version 57 (16 Jan 2019)
Sequence version 1 (08 Apr 2008)
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Protein

Molybdenum cofactor sulfurase 2

Gene

mal2

Organism
Culex quinquefasciatus (Southern house mosquito) (Culex pungens)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pyridoxal 5'-phosphateUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei389UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processMolybdenum cofactor biosynthesis
LigandPyridoxal phosphate

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Molybdenum cofactor sulfurase 2UniRule annotation (EC:2.8.1.9UniRule annotation)
Short name:
MCS 2UniRule annotation
Short name:
MOS 2UniRule annotation
Short name:
MoCo sulfurase 2UniRule annotation
Alternative name(s):
Molybdenum cofactor sulfurtransferase 2UniRule annotation
Protein maroon-like 2UniRule annotation
Short name:
Ma-l 2UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mal2UniRule annotation
ORF Names:CPIJ009941
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCulex quinquefasciatus (Southern house mosquito) (Culex pungens)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7176 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeCulicinaeCuliciniCulexCulex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002320 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Partially assembled WGS sequence

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003693691 – 760Molybdenum cofactor sulfurase 2Add BLAST760

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei223N6-(pyridoxal phosphate)lysineUniRule annotation1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7176.CPIJ009941-PA

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
B0WSX1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B0WSX1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini608 – 758MOSCUniRule annotationAdd BLAST151

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2142 Eukaryota
COG0520 LUCA
COG3217 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000029698

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B0WSX1

KEGG Orthology (KO)

More...
KOi
K15631

Identification of Orthologs from Complete Genome Data

More...
OMAi
RVNTYDC

Database of Orthologous Groups

More...
OrthoDBi
394559at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B0WSX1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.640.10, 1 hit
3.90.1150.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_03050 MOCOS, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000192 Aminotrans_V_dom
IPR020845 AMP-binding_CS
IPR005302 MoCF_Sase_C
IPR028886 MoCo_sulfurase
IPR005303 MOSC_N
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
IPR011037 Pyrv_Knase-like_insert_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00266 Aminotran_5, 1 hit
PF03473 MOSC, 1 hit
PF03476 MOSC_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50800 SSF50800, 1 hit
SSF53383 SSF53383, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51340 MOSC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B0WSX1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMEQFESVF TAKENAEIAK EFTRLKDTCY LDHAGTTLYA DSQIRAVGDC
60 70 80 90 100
LTGSLFCNPH TSRTTEDLLD QVRFRVLRHF GTHPSEYGLV FTSGTTGALK
110 120 130 140 150
LVAECFDFGD EGAFVYTRDN HTSVLGMRAV VGTERIVPIG REDLRGGRST
160 170 180 190 200
GGGKSSLVVF PAQCNFNGFK YPLGLVEDIQ RNGLVGFDGD RFHVCLDAAS
210 220 230 240 250
FVSTNALDLA KHQPSFVCLS FYKIFGFPTG LGALLVHRSA QNLLKKRYYG
260 270 280 290 300
GGTVKIAMAG RNFHVKRDSL ADQFEDGTVP FTSIISLLQG FETLERLVPA
310 320 330 340 350
SGELSSIDRV SRHTFALGRY CFQRLRGLRH ANSNSVVKLY HDTEFEDRGS
360 370 380 390 400
QGGIVNFNVL HEDGSFVGFA EVAYMASVHN VVLRTGCFCN PGACQRLLEL
410 420 430 440 450
TDEDVLKQFN AGHVCGDAND LIGGQPTGSV RVSFGYMSRR EDVDRLVEMV
460 470 480 490 500
EKCYVKKMTA NGLTRKQIVS NYKNYDQPKL KMICLFPIKS CGAYKITTSW
510 520 530 540 550
PLCHKGLKHD REFVIVDENG VAMTQKKLVE MCLIKPKIDI KTNTLILTHP
560 570 580 590 600
AMENFTLSME PLSNESQSIK LCQTKVCQDN VQAIDCGDAV ANWISIALQT
610 620 630 640 650
SGLRLLKQSD DEARTLRKST TEIALSNQAQ FLLINQASVR WLADLVPDWD
660 670 680 690 700
DLSQEPTLES LVDRFRGNLI IDSVKPLEES SWTQLRIGPL EFSVDGPCSR
710 720 730 740 750
CQMICIDQSS GTRTAEPLRT IAREFKGKMR FGIYLSHVKS LEGSDEKLLH
760
CGSPLQVVAE
Length:760
Mass (Da):84,400
Last modified:April 8, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFD8B94CB4F87B4F2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DS232077 Genomic DNA Translation: EDS34099.1

NCBI Reference Sequences

More...
RefSeqi
XP_001870738.1, XM_001870703.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
CPIJ009941-RA; CPIJ009941-PA; CPIJ009941

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6042721

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cqu:CpipJ_CPIJ009941

Bioinformatics Resource for Invertebrate Vectors of Human Pathogens

More...
VectorBasei
CPIJ009941-RA; CPIJ009941-PA; CPIJ009941

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS232077 Genomic DNA Translation: EDS34099.1
RefSeqiXP_001870738.1, XM_001870703.1

3D structure databases

ProteinModelPortaliB0WSX1
SMRiB0WSX1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7176.CPIJ009941-PA

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiCPIJ009941-RA; CPIJ009941-PA; CPIJ009941
GeneIDi6042721
KEGGicqu:CpipJ_CPIJ009941
VectorBaseiCPIJ009941-RA; CPIJ009941-PA; CPIJ009941

Phylogenomic databases

eggNOGiKOG2142 Eukaryota
COG0520 LUCA
COG3217 LUCA
HOGENOMiHOG000029698
InParanoidiB0WSX1
KOiK15631
OMAiRVNTYDC
OrthoDBi394559at2759
PhylomeDBiB0WSX1

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
HAMAPiMF_03050 MOCOS, 1 hit
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR020845 AMP-binding_CS
IPR005302 MoCF_Sase_C
IPR028886 MoCo_sulfurase
IPR005303 MOSC_N
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
IPR011037 Pyrv_Knase-like_insert_dom_sf
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
PF03473 MOSC, 1 hit
PF03476 MOSC_N, 1 hit
SUPFAMiSSF50800 SSF50800, 1 hit
SSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS51340 MOSC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMOCO2_CULQU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B0WSX1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: January 16, 2019
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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