We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - B0WC46 (TRET1_CULQU)
Protein
Facilitated trehalose transporter Tret1
Gene
Tret1
Organism
Culex quinquefasciatus (Southern house mosquito) (Culex pungens)
Status
Functioni
High-capacity facilitative transporter for trehalose. Does not transport maltose, sucrose or lactose. Mediates the bidirectional transfer of trehalose. Responsible for the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source, thereby regulating trehalose levels in the hemolymph (By similarity).
By similarityGO - Molecular functioni
- sugar transmembrane transporter activity Source: InterPro
- trehalose transmembrane transporter activity Source: UniProtKB
GO - Biological processi
- trehalose transport Source: UniProtKB
Keywordsi
Biological process | Sugar transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Facilitated trehalose transporter Tret1By similarity |
Gene namesi | Name:Tret1By similarity ORF Names:CPIJ004516 |
Organismi | Culex quinquefasciatus (Southern house mosquito) (Culex pungens) |
Taxonomic identifieri | 7176 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicoidea › Culicidae › Culicinae › Culicini › Culex › Culex › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | VectorBase:CPIJ004516 |
Subcellular locationi
Plasma membrane
- Cell membrane Sequence analysisBy similarity; Multi-pass membrane protein Sequence analysisBy similarity
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 56 | CytoplasmicSequence analysisAdd BLAST | 56 | |
Transmembranei | 57 – 77 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 78 – 100 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 101 – 121 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 122 – 135 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 136 – 156 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 157 – 158 | ExtracellularSequence analysis | 2 | |
Transmembranei | 159 – 179 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 180 – 184 | CytoplasmicSequence analysis | 5 | |
Transmembranei | 185 – 205 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 206 – 212 | ExtracellularSequence analysis | 7 | |
Transmembranei | 213 – 233 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 234 – 296 | CytoplasmicSequence analysisAdd BLAST | 63 | |
Transmembranei | 297 – 317 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 318 – 333 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 334 – 354 | Helical; Name=8Sequence analysisAdd BLAST | 21 | |
Topological domaini | 355 – 360 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 361 – 381 | Helical; Name=9Sequence analysisAdd BLAST | 21 | |
Topological domaini | 382 – 392 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 393 – 413 | Helical; Name=10Sequence analysisAdd BLAST | 21 | |
Topological domaini | 414 – 437 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 438 – 458 | Helical; Name=11Sequence analysisAdd BLAST | 21 | |
Topological domaini | 459 – 461 | ExtracellularSequence analysis | 3 | |
Transmembranei | 462 – 482 | Helical; Name=12Sequence analysisAdd BLAST | 21 | |
Topological domaini | 483 – 517 | CytoplasmicSequence analysisAdd BLAST | 35 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000395541 | 1 – 517 | Facilitated trehalose transporter Tret1Add BLAST | 517 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 88 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinFamily & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily. [View classification]Sequence analysisBy similarity
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0254, Eukaryota |
HOGENOMi | CLU_001265_30_5_1 |
InParanoidi | B0WC46 |
OMAi | QAVIKWR |
OrthoDBi | 430696at2759 |
PhylomeDBi | B0WC46 |
Family and domain databases
CDDi | cd17358, MFS_GLUT6_8_Class3_like, 1 hit |
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR020846, MFS_dom IPR044775, MFS_ERD6/Tret1-like IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
i Sequence
Sequence statusi: Complete.
B0WC46-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWIEIPECYE VLRNVFSKFR RHSLTAAMVK LLMRADTHVS FTVPAEEPVA
60 70 80 90 100
KCTFSQVLAA LSVSLGSMVV GFSSAYTSPA LVSMKDRNIT SFEVTDQSGS
110 120 130 140 150
WVGGIMPLAG LVGGILGGPL IEYLGRKNTI LATATPFIIS WLLIACATHV
160 170 180 190 200
AMVLVGRALS GFSVGVASLS LPVYLGETVQ PEVRGTLGLL PTAFGNIGIL
210 220 230 240 250
LCFVAGNYMD WSELAFLGAT LPVPFLILMF LIPETPRWYV SRGRDDRARK
260 270 280 290 300
ALQWLRGKKA DVDPELKGII KSHQDAERHA SQSAMLDLLK KTNLKPLLIS
310 320 330 340 350
LGLMFFQQLS GINAVIFYTV QIFQDAGSTI DENLCTIIVG VVNFIATFIA
360 370 380 390 400
TLLIDRLGRK MLLYISDIAM IITLMTLGGF FYVKNNGGDV SHIGWLPLAS
410 420 430 440 450
FVIFVLGFSL GFGPIPWLMM GEILPGKIRG SAASVATAFN WSCTFVVTKT
460 470 480 490 500
FADIIASIGT HGAFWMFGSV CVVGLVFVIM YVPETQGKSL EDIERKMCGR
510
VRRMSSVANI KPLSFNM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DS231885 Genomic DNA Translation: EDS43198.1 |
RefSeqi | XP_001846280.1, XM_001846228.1 |
Genome annotation databases
GeneIDi | 6036204 |
KEGGi | cqu:CpipJ_CPIJ004516 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DS231885 Genomic DNA Translation: EDS43198.1 |
RefSeqi | XP_001846280.1, XM_001846228.1 |
3D structure databases
SMRi | B0WC46 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7176.CPIJ004516-PA |
Genome annotation databases
GeneIDi | 6036204 |
KEGGi | cqu:CpipJ_CPIJ004516 |
Organism-specific databases
VEuPathDBi | VectorBase:CPIJ004516 |
Phylogenomic databases
eggNOGi | KOG0254, Eukaryota |
HOGENOMi | CLU_001265_30_5_1 |
InParanoidi | B0WC46 |
OMAi | QAVIKWR |
OrthoDBi | 430696at2759 |
PhylomeDBi | B0WC46 |
Family and domain databases
CDDi | cd17358, MFS_GLUT6_8_Class3_like, 1 hit |
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR020846, MFS_dom IPR044775, MFS_ERD6/Tret1-like IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TRET1_CULQU | |
Accessioni | B0WC46Primary (citable) accession number: B0WC46 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 13, 2010 |
Last sequence update: | April 8, 2008 | |
Last modified: | February 23, 2022 | |
This is version 69 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families