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Entry version 70 (18 Sep 2019)
Sequence version 1 (08 Apr 2008)
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Protein
Submitted name:

Anaphase-promoting complex subunit 2

Gene

6035478

Organism
Culex quinquefasciatus (Southern house mosquito) (Culex pungens)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Anaphase-promoting complex subunit 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:6035478Imported
ORF Names:CpipJ_CPIJ003980Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCulex quinquefasciatus (Southern house mosquito) (Culex pungens)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7176 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeCulicinaeCuliciniCulexCulex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002320 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Partially assembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7176.CPIJ003980-PA

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini424 – 661CULLIN_2InterPro annotationAdd BLAST238

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cullin family.PROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2165 Eukaryota
ENOG410XRBY LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000033936

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B0WAC8

KEGG Orthology (KO)

More...
KOi
K03349

Identification of Orthologs from Complete Genome Data

More...
OMAi
SMVVDIY

Database of Orthologous Groups

More...
OrthoDBi
570797at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B0WAC8

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014786 APC_su2_C
IPR016158 Cullin_homology
IPR036317 Cullin_homology_sf
IPR001373 Cullin_N
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08672 ANAPC2, 1 hit
PF00888 Cullin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01013 APC2, 1 hit
SM00182 CULLIN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit
SSF75632 SSF75632, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50069 CULLIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B0WAC8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLNDNICASL YKVFPLLEDK LTVAPVTDHE ISQLSVQLER ELPVIYEAIF
60 70 80 90 100
FKIDRCLRHQ TVPRFWRHFN QSPVPSKSPG TNRHFFRFQQ AVRELYDEFG
110 120 130 140 150
QYWLQLKRLE KLRRGVVLPV DVAKRPSDLS EFFRMFRCGL LAQLPVDFNE
160 170 180 190 200
LVYEFYGIAF KVFALTHADS EESMEVGETA FQCGACGLES VNCQCQSLAS
210 220 230 240 250
AFTSTNRQLA AMGLLDKIAG FTLTTLIQER IDAKIGETKE NFSVSHLEAL
260 270 280 290 300
ERWLNTVVLQ WLTRIYNRGS LTIAPGNVKI EEAIGNFQTK LSFYLYENYA
310 320 330 340 350
NAIIEQFFGI IIDFPMSQAA IDDLKLCLEK IDLKSYLIKT VKGTLESKLL
360 370 380 390 400
HPGVDTPDIL TGYVAAIKTL RHLDPTGVLL QTITEPVKEY LRSRPDTVRC
410 420 430 440 450
VVTGLTEEGC SDLSEELAKS EHIKAKENIN EKLELTDWEN WNPDPVNADA
460 470 480 490 500
VLSKEARLGR PSDIISMVVD IYGSKELFVN EYRNLLAERL LSQLDSNPEK
510 520 530 540 550
EIRNLELLKL RFGETMLHSC EVMLKDISDS KRINSHILSA ESGFPSERPF
560 570 580 590 600
DISALIVSSQ FWPTFKKETM DLPPAIKEVF DQYTKSFEAY KGSRTLHWTP
610 620 630 640 650
LNGKVTIELE LDGKITEMQV TPAQATIAIH FSEQREWELE KLGQQMNMPP
660 670 680 690 700
SVLRKRLVFW QSQGLIRETR ENLFILNDRQ SESNAAELHN APAPDVCEDE
710 720 730 740 750
EAESAMESAS DQREEELQVF WSYIEAMLTN LDSLPLDRIH QMLKMFASQV
760 770 780
DFSQEELKNI LQRKVREHKL VYAGGVYQLP KA
Length:782
Mass (Da):89,509
Last modified:April 8, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8F296746A3CFF4FB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DS231870 Genomic DNA Translation: EDS41018.1

NCBI Reference Sequences

More...
RefSeqi
XP_001845662.1, XM_001845610.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
CPIJ003980-RA; CPIJ003980-PA; CPIJ003980

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6035478

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cqu:CpipJ_CPIJ003980

Bioinformatics Resource for Invertebrate Vectors of Human Pathogens

More...
VectorBasei
CPIJ003980-RA; CPIJ003980-PA; CPIJ003980

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231870 Genomic DNA Translation: EDS41018.1
RefSeqiXP_001845662.1, XM_001845610.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7176.CPIJ003980-PA

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiCPIJ003980-RA; CPIJ003980-PA; CPIJ003980
GeneIDi6035478
KEGGicqu:CpipJ_CPIJ003980
VectorBaseiCPIJ003980-RA; CPIJ003980-PA; CPIJ003980

Phylogenomic databases

eggNOGiKOG2165 Eukaryota
ENOG410XRBY LUCA
HOGENOMiHOG000033936
InParanoidiB0WAC8
KOiK03349
OMAiSMVVDIY
OrthoDBi570797at2759
PhylomeDBiB0WAC8

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR014786 APC_su2_C
IPR016158 Cullin_homology
IPR036317 Cullin_homology_sf
IPR001373 Cullin_N
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF08672 ANAPC2, 1 hit
PF00888 Cullin, 1 hit
SMARTiView protein in SMART
SM01013 APC2, 1 hit
SM00182 CULLIN, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF75632 SSF75632, 1 hit
PROSITEiView protein in PROSITE
PS50069 CULLIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB0WAC8_CULQU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B0WAC8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: September 18, 2019
This is version 70 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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