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Entry version 75 (16 Jan 2019)
Sequence version 1 (08 Apr 2008)
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Protein
Submitted name:

Endoribonuclease Dcr-1

Gene

6034442

Organism
Culex quinquefasciatus (Southern house mosquito) (Culex pungens)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-bindingPROSITE-ProRule annotation
Biological processRNA-mediated gene silencingSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Endoribonuclease Dcr-1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:6034442Imported
ORF Names:CpipJ_CPIJ003169Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCulex quinquefasciatus (Southern house mosquito) (Culex pungens)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7176 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeCulicinaeCuliciniCulexCulex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002320 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Partially assembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7176.CPIJ003169-PA

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
B0W7S3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 188Helicase ATP-bindingInterPro annotationAdd BLAST166
Domaini480 – 653Helicase C-terminalInterPro annotationAdd BLAST174
Domaini1121 – 1268PAZInterPro annotationAdd BLAST148
Domaini1733 – 1938RNase IIIInterPro annotationAdd BLAST206
Domaini2014 – 2171RNase IIIInterPro annotationAdd BLAST158
Domaini2196 – 2262DRBMInterPro annotationAdd BLAST67

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1545 – 1565Sequence analysisAdd BLAST21
Coiled coili1872 – 1892Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0701 Eukaryota
COG0571 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000001567

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B0W7S3

KEGG Orthology (KO)

More...
KOi
K11592

Identification of Orthologs from Complete Genome Data

More...
OMAi
PKPDQPC

Database of Orthologous Groups

More...
OrthoDBi
1337630at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B0W7S3

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00048 DSRM, 1 hit
cd00079 HELICc, 1 hit
cd00593 RIBOc, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1520.10, 1 hit
3.30.160.380, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR014720 dsRBD_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR003100 PAZ_dom
IPR036085 PAZ_dom_sf
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03368 Dicer_dimer, 2 hits
PF00271 Helicase_C, 1 hit
PF02170 PAZ, 1 hit
PF00636 Ribonuclease_3, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00358 DSRM, 1 hit
SM00490 HELICc, 1 hit
SM00949 PAZ, 1 hit
SM00535 RIBOc, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101690 SSF101690, 1 hit
SSF52540 SSF52540, 1 hit
SSF69065 SSF69065, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50137 DS_RBD, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50821 PAZ, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B0W7S3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHSWTDAIH TTSLTPRDFQ VELLASARER NLILCLAHNS NKEFIALKLI
60 70 80 90 100
HELGFQLRST AQRRKRTLYI SNNDSVYSLM RNLTDLKVVH VDGDEPDWER
110 120 130 140 150
IVADYQVIIA NERKCLDAVV CGYLELDEVN LLVIDECHKI YGNVEIAELF
160 170 180 190 200
SEYYERCRER PKILGLAGPL HNAGCIPGRL SAELEQLERC LKAKAETASD
210 220 230 240 250
IVTVLRYCTK PKELILQCAP PQQSELALYL REIVETQMTF LQEHRYDPSE
260 270 280 290 300
IYEDDEFLEE LKHIPDPKVD PLNFLREFLT VLDEMGPWCA DRAALALIVQ
310 320 330 340 350
IEKRKIKTPY ERHFLLLCLV STVFVQIRSY CDLVFQQYAT ELERIEAHST
360 370 380 390 400
PKVLRMLEIF RLFRPDGANR GTVSSKAPIK EVTESCQLPS CQSLLKEIKT
410 420 430 440 450
VDFQKFVDRV ETVTSSIAII TEGLESLKTS VKSISDAPPL KQNLVFNEKK
460 470 480 490 500
PRSPFKNGIR QIRQRKKIGF THRNRSNFHN QNDPDALCAL IFCNSKFTTK
510 520 530 540 550
ILYSLLYEAV RSDPQLSYIN VQYTVDKSAN PITEPKEAEV EHRKQEEVLK
560 570 580 590 600
RFRMHECNLL IGTSVLEEGI DLPKCNLVIR WNEPVSYRSY VQCKGRARAP
610 620 630 640 650
SAYHILIVTP KVDQLLAANG ARDDLSEQVH RKVCERTSRV RMEEEESDDD
660 670 680 690 700
DEEKRPTSLS GSNLCLVKNS ETIAEETQKL GLQVMENCTN EMIEKIAIYM
710 720 730 740 750
EIEKLLLRKC ENMEPPESEL KHADCFSRFF EIYRPLPETE ENSNGVGLAN
760 770 780 790 800
AIQMINKYCA KLPSDTFTKL TPLWRCAKTT RKGHDLYQYT IRMPINSPLK
810 820 830 840 850
EDILFHSLRA DGKGRVLGDL VDGVDSVRNK RDATAGGIAR NRFGVLLLQF
860 870 880 890 900
HTELVVVAKK LSGCAAQGLS VKLHQAYDRF RRGSFRYAGN GGGFNEAGHF
910 920 930 940 950
EGLPMPTEIL ARRMAAYIAC RVLHNAGEID DSLHPIGKES FRAFEADWED
960 970 980 990 1000
FELESIDAQI VSENSEPRPG TTKRRQYYYK RIASAFSECR PTVGCKVYLY
1010 1020 1030 1040 1050
HINMTLQCPI PEEQNTRGRR IYPPEDSPQG FGILTAKLIP KVSAFPIFTR
1060 1070 1080 1090 1100
SGEVKVALNL CAERTILNQE QLDKINLFIN YTFTKVLRLQ KYLMLYDPMA
1110 1120 1130 1140 1150
TENCFFIVPT ITRQSVVTVD WDFIDIIAKS VDKMPTFIPD ENRTNYTFDN
1160 1170 1180 1190 1200
IQFRDAVVMP WYRNQDQPQY FYVAEICYHL SPKSSFPGLN YSTFEEYYYK
1210 1220 1230 1240 1250
KYNIQIQNCK QPLLDVDHTS ARLNFLTPRY VNRKGVALPT SSEETKRAKR
1260 1270 1280 1290 1300
ENLEQKQILI PELCTIHPFP ASLWRAAVCL PCILYRINAL LLADEIRKEV
1310 1320 1330 1340 1350
AHDLGLGATD ISDAQFEWPI LNFGWSLADV LKKSREAKLT AKAVLEEVPE
1360 1370 1380 1390 1400
LTEPEETDKK DDPVEGKADG VQKSEDPLSD EKTANDLLEE ADAKLKAEGF
1410 1420 1430 1440 1450
QIGTWSNEMA ESVQSEFMDD GENWGLPGNV NICSRNRTNI RYGSPTSWDV
1460 1470 1480 1490 1500
DNKEQPTDAR YYSDSEGSYG SDDELDSGGE ENDSDQGRYG LKIEFKSDNV
1510 1520 1530 1540 1550
AEAIESEDDI MKRQKQRDII NSTNMNEQLY QTSKNVSSGF DCTRNDELEI
1560 1570 1580 1590 1600
NVKLHEEQFE RSTNQFKEQI KNCGTLVKCD EKLTVENHLK QGRNAATVQS
1610 1620 1630 1640 1650
DERDIYELFP YASKQEVDRF LFTNDRGVTY MNLEGFYDLN RPYFPEKYSI
1660 1670 1680 1690 1700
IGTGDVFDRF NDENLLEVNE NNEKTITFNI EYPLVVRNQT KDNQKRTLPS
1710 1720 1730 1740 1750
VPNVATAING SLGEFSFDYQ PDLTNHPGPS PSIILQALTM SNANDGINLE
1760 1770 1780 1790 1800
RLETIGDSFL KYAITTYLYC TYENVHEGKL SHLRSKQVSN LNLYRLGRRK
1810 1820 1830 1840 1850
VLGESMIATK FEPHDNWLPP CYYVPKELEQ ALIDAKIPAC HWNLADLPDI
1860 1870 1880 1890 1900
KQLSSEEICK LVKERAQLLG LLDDSDNEEG EHMKEIQQLE IRNDEFIKNS
1910 1920 1930 1940 1950
DYFACFIPYN LVTQHSIPDK SVADCVEALI GAYLIECGPR GALLLMAWLG
1960 1970 1980 1990 2000
IRVLPVCEQP FDPTAPRIPG SSAPYEVNGK QIQSIYGYWI PPRSPLLTHA
2010 2020 2030 2040 2050
PNPEKSLEHL LDGYSAFEDS LGYRFQDRSY LLQAMTHASY CPNRLTDCYQ
2060 2070 2080 2090 2100
RLEFLGDAVL DYLITRHLYE DPRQHSPGAL TDLRSALVNN TIFASLAVRH
2110 2120 2130 2140 2150
DFHKYFRHLS PGLNDVIDRF VRIQQDNGHS ISEEYYLISE DECDEAEDVE
2160 2170 2180 2190 2200
VPKALGDVFE SVAGAIFLDS NMSLDAVWRV YRGMMGPEIE QFSNSVPKSP
2210 2220 2230 2240 2250
IRELLELEPE TAKFGKPEKL ADGRRVRVTV EVFGKGTFRG IGRNYRIAKC
2260 2270
TAAKCALRQL KKMGLINKRR
Length:2,270
Mass (Da):259,540
Last modified:April 8, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCD2E69C26126F6EE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DS231855 Genomic DNA Translation: EDS38217.1

NCBI Reference Sequences

More...
RefSeqi
XP_001844757.1, XM_001844705.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Cpi.1117

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
CPIJ003169-RA; CPIJ003169-PA; CPIJ003169

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6034442

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cqu:CpipJ_CPIJ003169

Bioinformatics Resource for Invertebrate Vectors of Human Pathogens

More...
VectorBasei
CPIJ003169-RA; CPIJ003169-PA; CPIJ003169

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231855 Genomic DNA Translation: EDS38217.1
RefSeqiXP_001844757.1, XM_001844705.1
UniGeneiCpi.1117

3D structure databases

ProteinModelPortaliB0W7S3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7176.CPIJ003169-PA

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiCPIJ003169-RA; CPIJ003169-PA; CPIJ003169
GeneIDi6034442
KEGGicqu:CpipJ_CPIJ003169
VectorBaseiCPIJ003169-RA; CPIJ003169-PA; CPIJ003169

Phylogenomic databases

eggNOGiKOG0701 Eukaryota
COG0571 LUCA
HOGENOMiHOG000001567
InParanoidiB0W7S3
KOiK11592
OMAiPKPDQPC
OrthoDBi1337630at2759
PhylomeDBiB0W7S3

Family and domain databases

CDDicd00048 DSRM, 1 hit
cd00079 HELICc, 1 hit
cd00593 RIBOc, 2 hits
Gene3Di1.10.1520.10, 1 hit
3.30.160.380, 2 hits
InterProiView protein in InterPro
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR014720 dsRBD_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR003100 PAZ_dom
IPR036085 PAZ_dom_sf
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF03368 Dicer_dimer, 2 hits
PF00271 Helicase_C, 1 hit
PF02170 PAZ, 1 hit
PF00636 Ribonuclease_3, 2 hits
SMARTiView protein in SMART
SM00358 DSRM, 1 hit
SM00490 HELICc, 1 hit
SM00949 PAZ, 1 hit
SM00535 RIBOc, 2 hits
SUPFAMiSSF101690 SSF101690, 1 hit
SSF52540 SSF52540, 1 hit
SSF69065 SSF69065, 2 hits
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50821 PAZ, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB0W7S3_CULQU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B0W7S3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: January 16, 2019
This is version 75 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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