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Entry version 53 (26 Feb 2020)
Sequence version 1 (08 Apr 2008)
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Protein

Clustered mitochondria protein homolog

Gene

CPIJ001445

Organism
Culex quinquefasciatus (Southern house mosquito) (Culex pungens)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Clustered mitochondria protein homologUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CPIJ001445
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCulex quinquefasciatus (Southern house mosquito) (Culex pungens)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7176 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeCulicinaeCuliciniCulexCulex
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002320 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Partially assembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003663781 – 1377Clustered mitochondria protein homologAdd BLAST1377

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7176.CPIJ001445-PA

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B0W2S0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini353 – 595CluPROSITE-ProRule annotationAdd BLAST243
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati519 – 552TPR 1Add BLAST34
Repeati1022 – 1055TPR 2Add BLAST34
Repeati1148 – 1181TPR 3Add BLAST34
Repeati1183 – 1216TPR 4Add BLAST34

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CLU family.UniRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1839 Eukaryota
ENOG410XQUQ LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003256_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B0W2S0

KEGG Orthology (KO)

More...
KOi
K03255

Identification of Orthologs from Complete Genome Data

More...
OMAi
GFPMDGQ

Database of Orthologous Groups

More...
OrthoDBi
60958at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B0W2S0

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15466 CLU-central, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_03013 CLU, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027523 CLU
IPR033646 CLU-central
IPR025697 CLU_dom
IPR028275 CLU_N
IPR007967 GSKIP_dom
IPR011990 TPR-like_helical_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13236 CLU, 1 hit
PF15044 CLU_N, 1 hit
PF05303 DUF727, 1 hit
PF12807 eIF3_p135, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51823 CLU, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B0W2S0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLKSIQRNGK KQKNGSKDKE PTPPKEQPLV NGNHDMNGHA SDSVAPTEQQ
60 70 80 90 100
NGETKKKSDS EVMEIIQDAG FTVQIMSPGV EPLSIQVSSM ELVQEIHQLL
110 120 130 140 150
MDREDTCHRT CFSLQLDGVT LDNFAELKNV EGLKEGSVIK VVEEPYTMRE
160 170 180 190 200
ARIHVRHVRD LLKSMDPADA YNGVDCSSLT FLHTITAGDI LEKKKGRSDS
210 220 230 240 250
VDCTPPEYIM PGAKERPLLP LQPGVGKKGP QPLKVLTTSA WNPPPGPRKL
260 270 280 290 300
HGDLMYLYVV TMEDKRFHIS ACPRGFYINQ STDDTFEPRP DNPSYLCHSL
310 320 330 340 350
IDLLSQISPT FRRCFAQMQK KRTQRHPFER VATPYQVYTW SAPTLDHTID
360 370 380 390 400
AIRAEDTFSS KLGYEEHIPG QTRDWNEELQ TTRELPRETL PERLLRERAI
410 420 430 440 450
FKVHSDFVTA ATRGAMAVID GNVMAINPGE DAKMQMFIWN NIFFSLGFDV
460 470 480 490 500
RDHYKELGGD AAAFVAPRND LHGVRVYSAV DVEGLYTLGT VVIDYRGYRV
510 520 530 540 550
TAQSIIPGIL EREQEQSVVY GSIDFGKTVL SHEKYLELLN NAGKHLKIYP
560 570 580 590 600
HSVLNDDEEE IELCSSVECK GIIGNDGRHY ILDLLRTFPP DVNFLKLDEE
610 620 630 640 650
LSKDCKAFGF PIEHKHKLSC LRQELLEAFI ESRYLLFIKH AAFQLQQLNT
660 670 680 690 700
NKRQQKQDTP KEETKAIEPA AKEDSANNNK EEPAAKKGEP KAATGGVPKV
710 720 730 740 750
ETEEAKKLME SLLSSDEKNE SREVVKRACE AVGSLKDYEF DIRFNPDVYS
760 770 780 790 800
PGIQHVDNPN AANSIKKQKQ LVKDAAEFLV KHQIPSFVHD CLDHTAAPMD
810 820 830 840 850
GSTLTETLHS RGINVRYLGK VANLLAKIKQ LEYLHTIAVS ELIIRAAKHI
860 870 880 890 900
FVTYMQNTEM MSMAAAISHF LNCFLTTATS VSSESDVLTK SGSSGKQQRK
910 920 930 940 950
QNKRTAAGGG KGGKSSFQCT QDNNEWQLLT SKSLWAQIQQ ELKSYWDYDL
960 970 980 990 1000
LPAGTVDSAD PVVTHNHLQK ISLLRAFCLK TGVQILLREY NFETKNKPTF
1010 1020 1030 1040 1050
NENDIVNVFP VVKHINPRAS DAYNFYTTGQ TKIQQGYFKD GYDLISEALN
1060 1070 1080 1090 1100
LLNNVYGAMH PENAQCLRML ARLSYIMGDP QEALAIQQRA VLMSERVNGI
1110 1120 1130 1140 1150
DHPYTIAEYA PLALYCFANS QISTALKLLY RARYLATIVC GDNHPDIALL
1160 1170 1180 1190 1200
DSNISLILHA VGEYELSLRF LEHALALNIK YYGEKSLKVA VSYHLVARTQ
1210 1220 1230 1240 1250
SCMGDFRSAL NNEKETYAIY KQQLGEAHEK TQESSECLRH LTQQAVVLQK
1260 1270 1280 1290 1300
KMNDIYSNGK LTTGLPPIHI QPPSMGSVLD MLNAINGIIF VQISSKEIAN
1310 1320 1330 1340 1350
LKNEIEKRQK EGGAAGESSV AQANQEEVDR LLTETMAKTA AGIPFEEQDN
1360 1370
YELPLPAATT GDEASSSSKA NPVASSS
Length:1,377
Mass (Da):154,112
Last modified:April 8, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF97A9841848990AB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DS231828 Genomic DNA Translation: EDS29823.1

NCBI Reference Sequences

More...
RefSeqi
XP_001843004.1, XM_001842952.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
CPIJ001445-RA; CPIJ001445-PA; CPIJ001445

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6032399

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cqu:CpipJ_CPIJ001445

Bioinformatics Resource for Invertebrate Vectors of Human Pathogens

More...
VectorBasei
CPIJ001445-RA; CPIJ001445-PA; CPIJ001445

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231828 Genomic DNA Translation: EDS29823.1
RefSeqiXP_001843004.1, XM_001842952.1

3D structure databases

SMRiB0W2S0
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7176.CPIJ001445-PA

Genome annotation databases

EnsemblMetazoaiCPIJ001445-RA; CPIJ001445-PA; CPIJ001445
GeneIDi6032399
KEGGicqu:CpipJ_CPIJ001445
VectorBaseiCPIJ001445-RA; CPIJ001445-PA; CPIJ001445

Phylogenomic databases

eggNOGiKOG1839 Eukaryota
ENOG410XQUQ LUCA
HOGENOMiCLU_003256_1_0_1
InParanoidiB0W2S0
KOiK03255
OMAiGFPMDGQ
OrthoDBi60958at2759
PhylomeDBiB0W2S0

Family and domain databases

CDDicd15466 CLU-central, 1 hit
Gene3Di1.25.40.10, 1 hit
HAMAPiMF_03013 CLU, 1 hit
InterProiView protein in InterPro
IPR027523 CLU
IPR033646 CLU-central
IPR025697 CLU_dom
IPR028275 CLU_N
IPR007967 GSKIP_dom
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF13236 CLU, 1 hit
PF15044 CLU_N, 1 hit
PF05303 DUF727, 1 hit
PF12807 eIF3_p135, 1 hit
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS51823 CLU, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLU_CULQU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B0W2S0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 8, 2008
Last modified: February 26, 2020
This is version 53 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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