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Protein

UDP-3-O-acylglucosamine N-acyltransferase

Gene

lpxD

Organism
Acinetobacter baumannii (strain SDF)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein].UniRule annotation

Pathwayi: LPS lipid A biosynthesis

This protein is involved in the pathway LPS lipid A biosynthesis, which is part of Bacterial outer membrane biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway LPS lipid A biosynthesis and in Bacterial outer membrane biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei242Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayi
UPA00973

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-3-O-acylglucosamine N-acyltransferaseUniRule annotation (EC:2.3.1.-UniRule annotation)
Gene namesi
Name:lpxDUniRule annotation
Ordered Locus Names:ABSDF1688
OrganismiAcinetobacter baumannii (strain SDF)
Taxonomic identifieri509170 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
Proteomesi
  • UP000001741 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001276561 – 356UDP-3-O-acylglucosamine N-acyltransferaseAdd BLAST356

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Structurei

Secondary structure

1356
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliB0VMV2
SMRiB0VMV2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transferase hexapeptide repeat family. LpxD subfamily.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000294339
KOiK02536
OMAiGFGYAHT

Family and domain databases

CDDicd03352 LbH_LpxD, 1 hit
HAMAPiMF_00523 LpxD, 1 hit
InterProiView protein in InterPro
IPR001451 Hexapep
IPR007691 LpxD
IPR011004 Trimer_LpxA-like_sf
IPR020573 UDP_GlcNAc_AcTrfase_non-rep
PANTHERiPTHR43378 PTHR43378, 1 hit
PfamiView protein in Pfam
PF00132 Hexapep, 3 hits
PF14602 Hexapep_2, 1 hit
PF04613 LpxD, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit
TIGRFAMsiTIGR01853 lipid_A_lpxD, 1 hit

Sequencei

Sequence statusi: Complete.

B0VMV2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVQQYRLDE LAHLVKGELI GEGSLQFSNL ASLENAEVNH LTFVNGEKHL
60 70 80 90 100
DQAKVSRAGA YIVTAALKEH LPEKDNFIIV DNPYLAFAIL THVFDKKISS
110 120 130 140 150
TGIESTARIH PSAVISETAY IGHYVVIGEN CVVGDNTVIQ SHTKLDDNVE
160 170 180 190 200
VGKDCFIDSY VTITGSSKLR DRVRIHSSTV IGGEGFGFAP YQGKWHRIAQ
210 220 230 240 250
LGSVLIGNDV RIGSNCSIDR GALDNTILED GVIIDNLVQI AHNVHIGSNT
260 270 280 290 300
AIAAKCGIAG STKIGKNCIL AGACGVAGHL SIADNVTLTG MSMVTKNISE
310 320 330 340 350
AGTYSSGTGL FENNHWKKTI VRLRQLADVP LTQITKRLDH IQAQIESLES

TFNLRK
Length:356
Mass (Da):38,484
Last modified:April 8, 2008 - v1
Checksum:iBF15F948205840F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU468230 Genomic DNA Translation: CAP01028.1

Genome annotation databases

EnsemblBacteriaiCAP01028; CAP01028; ABSDF1688
KEGGiabm:ABSDF1688

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU468230 Genomic DNA Translation: CAP01028.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4E75X-ray2.85A/B/C/D/E/F2-355[»]
4E79X-ray2.66A/B/C2-355[»]
ProteinModelPortaliB0VMV2
SMRiB0VMV2
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAP01028; CAP01028; ABSDF1688
KEGGiabm:ABSDF1688

Phylogenomic databases

HOGENOMiHOG000294339
KOiK02536
OMAiGFGYAHT

Enzyme and pathway databases

UniPathwayi
UPA00973

Family and domain databases

CDDicd03352 LbH_LpxD, 1 hit
HAMAPiMF_00523 LpxD, 1 hit
InterProiView protein in InterPro
IPR001451 Hexapep
IPR007691 LpxD
IPR011004 Trimer_LpxA-like_sf
IPR020573 UDP_GlcNAc_AcTrfase_non-rep
PANTHERiPTHR43378 PTHR43378, 1 hit
PfamiView protein in Pfam
PF00132 Hexapep, 3 hits
PF14602 Hexapep_2, 1 hit
PF04613 LpxD, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit
TIGRFAMsiTIGR01853 lipid_A_lpxD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLPXD_ACIBS
AccessioniPrimary (citable) accession number: B0VMV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: October 10, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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