Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Receptor-type tyrosine-protein phosphatase S

Gene

Ptprs

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans (PubMed:19833921, PubMed:21454754, PubMed:22406547). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth (PubMed:21454754). Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection (PubMed:15797710, PubMed:19833921, PubMed:19780196, PubMed:21454754, PubMed:22519304, PubMed:22406547). Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2 (PubMed:21454754). Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb (PubMed:10080191). Functions as tyrosine phosphatase (PubMed:7529177). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (PubMed:15797710). Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PubMed:26231120).By similarity8 Publications

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation1 Publication1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1516SubstrateBy similarity1
Active sitei1548Phosphocysteine intermediateBy similarity1
Binding sitei1592SubstrateBy similarity1
Active sitei1839Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding, Hydrolase, Protein phosphatase, Receptor
Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-388844 Receptor-type tyrosine-protein phosphatases
R-MMU-8849932 Synaptic adhesion-like molecules

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase S (EC:3.1.3.481 Publication1 Publication)
Short name:
R-PTP-S
Alternative name(s):
PTPNU-3
Receptor-type tyrosine-protein phosphatase sigma
Short name:
R-PTP-sigma
Gene namesi
Name:Ptprs
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:97815 Ptprs

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 1257ExtracellularSequence analysisAdd BLAST1228
Transmembranei1258 – 1278HelicalSequence analysisAdd BLAST21
Topological domaini1279 – 1907CytoplasmicSequence analysisAdd BLAST629

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome

Pathology & Biotechi

Disruption phenotypei

Mating heterozygous mice gives rise to Ptprs deficient mice at the expected Mendelian rate, but the pups are somewhat lighter than their littermates at birth and display strongly impaired weight gain (PubMed:10080191). After about three weeks, mutant mice weigh only 50 to 55% of normal littermates, possibly due to reduced Igf1 levels in blood serum (PubMed:10080191). Pups born after crossing Ptprs deficient mice display about 41% lethality during the first day after birth (PubMed:10080191). Adult mutants have a reduced overall brain size, with a dramatic decrease in the size of the olfactory bulb (PubMed:10080191). As a consequence, mutant mice have strongly impaired ability to perceive repellent smells (PubMed:10080191). Females are less often in estrus (PubMed:10080191). Besides, mutant mice display a decreased overall size of the pituitary glands; relative to the total size, the intermediary lobe is enlarged with a concomitant decrease in the size of the anterior and posterior lobes (PubMed:10080191). Likewise, the size of the hypothalamus is decreased (PubMed:10080191). No visible effect on the structure of the retina and the optic nerve (PubMed:15797710). Mutant mice show increased axon outgrowth from retinal ganglion cells after optic nerve transection (PubMed:15797710). Mutant mice display increased axon outgrowth after spinal cord injury (PubMed:19833921, PubMed:19780196). In aging mice, mossy fibers in the CA3C region of the hippocampus show increased sprouting (PubMed:22519304). No difference in mossy fiber sprouting is seen in the CA3A region of the hippocampus (PubMed:22519304). After kainate-induced seizures, mutant mice show increased mossy fiber sprouting in both the CA3C and the CA3A region of the hippocampus (PubMed:22519304). Mutant mice display a slight increase in dendrite length and dendrite spine density in pyramidal cells in the CA1 region of the hippocampus, and subtle changes in miniature AMPAR-mediated excitatory post-synaptic currents (PubMed:22519304). Dorsal root ganglion neurons from mutant mice show decreased stimulation of neurite outgrowth in response to the heparan sulfate proteoglycan GPC2 (PubMed:21454754). Cerebellar granule neurons and dorsal root ganglion neurons from mutant mice show decreased inhibition of neurite outgrowth in response to chondroitin sulfate proteoglycan (PubMed:19833921, PubMed:19780196, PubMed:21454754, PubMed:22406547). Sensory neurons show increased axon outgrowth after spinal cord crush injury (PubMed:19833921). After optic nerve crush injury, mutant mice show no increase in axon regeneration (PubMed:22406547). Combined disruption of Rtn4r, Rtn4rl1 and Ptprs increases axon regeneration after injury (PubMed:22406547).7 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi68 – 72KKGKK → AAGAA: Abolishes binding to chondroitin sulfate proteoglycans. Abolishes receptor oligomerization via binding to large heparan sulfate proteoglycan structures. 2 Publications5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000035832130 – 1907Receptor-type tyrosine-protein phosphatase SAdd BLAST1878

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 107PROSITE-ProRule annotation
Disulfide bondi156 ↔ 207PROSITE-ProRule annotation
Glycosylationi250N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi253 ↔ 298PROSITE-ProRule annotation
Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi720N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi916N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei1197 – 1198CleavageBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiB0V2N1
PaxDbiB0V2N1
PeptideAtlasiB0V2N1
PRIDEiB0V2N1

PTM databases

iPTMnetiB0V2N1
PhosphoSitePlusiB0V2N1

Expressioni

Tissue specificityi

Detected in brain cortex, cerebellum and thoracic spinal cord (at protein level) (PubMed:19780196, PubMed:22519304). Detected in motor cortex and white matter of the spinal cord, but not in spinal cord gray matter (PubMed:19780196). Isoform 1 and isoform 6 are predominantly expressed in the brain (cerebrum and cerebellum) and to a lesser extent in the heart and skeletal muscle. Also found in neuronal-derived cell lines (PubMed:7529177). Detected in the ganglion cell layer of the retina and in glial cells along the optic nerve (PubMed:15797710). Detected in bone marrow and spleen plasmacytoid dendritic cells (PubMed:26231120).5 Publications

Developmental stagei

Expression is seen in embryos between 8 dpc and 16 dpc and a peak expression is seen at 14 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000013236 Expressed in 305 organ(s), highest expression level in brain
ExpressionAtlasiB0V2N1 baseline and differential
GenevisibleiB0V2N1 MM

Interactioni

Subunit structurei

Binding to large heparan sulfate proteoglycan structures promotes oligomerization (PubMed:21454754). Binding to chondroitin sulfate proteoglycan does not lead to oligomerization (PubMed:21454754). Interacts (via Ig-like domains) with NTRK3 (PubMed:25385546). Interacts (via Ig-like domains) with NTRK1, but does not form detectable complexes with NTRK2 (By similarity). Interacts with PPFIA1, PPFIA2 and PPFIA3 (By similarity).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202507, 3 interactors
IntActiB0V2N1, 5 interactors
STRINGi10090.ENSMUSP00000064048

Structurei

Secondary structure

11907
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliB0V2N1
SMRiB0V2N1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 123Ig-like C2-type 1Add BLAST91
Domaini135 – 224Ig-like C2-type 2Add BLAST90
Domaini232 – 314Ig-like C2-type 3Add BLAST83
Domaini321 – 411Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST91
Domaini416 – 510Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST95
Domaini514 – 603Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST90
Domaini608 – 705Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST98
Domaini710 – 809Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST100
Domaini810 – 906Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST97
Domaini907 – 1008Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST102
Domaini1011 – 1095Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST85
Domaini1352 – 1607Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST256
Domaini1639 – 1898Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST260

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni68 – 72Important for binding to glycosaminoglycan chains2 Publications5
Regioni1548 – 1554Substrate bindingBy similarity7

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4228 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00760000118900
HOVERGENiHBG053758
InParanoidiB0V2N1
KOiK06778
OMAiGGTERCG
OrthoDBiEOG091G11WG
PhylomeDBiB0V2N1
TreeFamiTF312900

Family and domain databases

CDDicd00063 FN3, 7 hits
Gene3Di2.60.40.10, 11 hits
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00041 fn3, 6 hits
PF07679 I-set, 3 hits
PF00102 Y_phosphatase, 2 hits
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 8 hits
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
SSF49265 SSF49265, 5 hits
SSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 8 hits
PS50835 IG_LIKE, 3 hits
PS00383 TYR_PHOSPHATASE_1, 2 hits
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits

Sequences (6+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: B0V2N1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPTWSPSVV SVVGPVGLFL VLLARGCLAE EPPRFIREPK DQIGVSGGVA
60 70 80 90 100
SFVCQATGDP KPRVTWNKKG KKVNSQRFET IDFDESSGAV LRIQPLRTPR
110 120 130 140 150
DENVYECVAQ NSVGEITIHA KLTVLREDQL PPGFPNIDMG PQLKVVERTR
160 170 180 190 200
TATMLCAASG NPDPEITWFK DFLPVDPSAS NGRIKQLRSG ALQIESSEET
210 220 230 240 250
DQGKYECVAT NSAGVRYSSP ANLYVRVRRV APRFSILPMS HEIMPGGNVN
260 270 280 290 300
ITCVAVGSPM PYVKWMQGAE DLTPEDDMPV GRNVLELTDV KDSANYTCVA
310 320 330 340 350
MSSLGVIEAV AQITVKSLPK APGTPVVTEN TATSITVTWD SGNPDPVSYY
360 370 380 390 400
VIEYKSKSQD GPYQIKEDIT TTRYSIGGLS PNSEYEIWVS AVNSIGQGPP
410 420 430 440 450
SESVVTRTGE QAPASAPRNV QARMLSATTM IVQWEEPVEP NGLIRGYRVY
460 470 480 490 500
YTMEPEHPVG NWQKHNVDDS LLTTVGSLLE DETYTVRVLA FTSVGDGPLS
510 520 530 540 550
DPIQVKTQQG VPGQPMNLRA EAKSETSIGL SWSAPRQESV IKYELLFREG
560 570 580 590 600
DRGREVGRTF DPTTAFVVED LKPNTEYAFR LAARSPQGLG AFTAVVRQRT
610 620 630 640 650
LQAKPSAPPQ DVKCTSLRST AILVSWRPPP PETHNGALVG YSVRYRPLGS
660 670 680 690 700
EDPDPKEVNN IPPTTTQILL EALEKWTEYR VTAVAYTEVG PGPESSPVVV
710 720 730 740 750
RTDEDVPSAP PRKVEAEALN ATAIRVLWRS PTPGRQHGQI RGYQVHYVRM
760 770 780 790 800
EGAEARGPPR IKDIMLADAQ EMVITNLQPE TAYSITVAAY TMKGDGARSK
810 820 830 840 850
PKVVVTKGAV LGRPTLSVQQ TPEGSLLARW EPPADAAEDP VLGYRLQFGR
860 870 880 890 900
EDAAPATLEL AAWERRFAAP AHKGATYVFR LAARGRAGLG EEAAAALSIP
910 920 930 940 950
EDAPRGFPQI LGAAGNVSAG SVLLRWLPPV PAERNGAIIK YTVSVREAGA
960 970 980 990 1000
PGPATETELA AAAQPGAETA LTLRGLRPET AYELRVRAHT RRGPGPFSPP
1010 1020 1030 1040 1050
LRYRLARDPV SPKNFKVKMI MKTSVLLSWE FPDNYNSPTP YKIQYNGLTL
1060 1070 1080 1090 1100
DVDGRTTKKL ITHLKPHTFY NFVLTNRGSS LGGLQQTVTA RTAFNMLSGK
1110 1120 1130 1140 1150
PSVAPKPDND GFIVVYLPDG QSPVTVQNYF IVMVPLRKSR GGQFPVLLGS
1160 1170 1180 1190 1200
PEDMDLEELI QDISRLQRRS LRHSRQLEVP RPYIAARFSI LPAVFHPGNQ
1210 1220 1230 1240 1250
KQYGGFDNRG LEPGHRYVLF VLAVLQKNEP TFAASPFSDP FQLDNPDPQP
1260 1270 1280 1290 1300
IVDGEEGLIW VIGPVLAVVF IICIVIAILL YKNKPDSKRK DSEPRTKCLL
1310 1320 1330 1340 1350
NNADLAPHHP KDPVEMRRIN FQTPGMLSHP PIPITDMAEH MERLKANDSL
1360 1370 1380 1390 1400
KLSQEYESID PGQQFTWEHS NLEANKPKNR YANVIAYDHS RVILQPLEGI
1410 1420 1430 1440 1450
MGSDYINANY VDGYRRQNAY IATQGPLPET FGDFWRMVWE QRSATVVMMT
1460 1470 1480 1490 1500
RLEEKSRIKC DQYWPNRGTE TYGFIQVTLL DTMELATFCV RTFSLHKNGS
1510 1520 1530 1540 1550
SEKREVRHFQ FTAWPDHGVP EYPTPFLAFL RRVKTCNPPD AGPIVVHCSA
1560 1570 1580 1590 1600
GVGRTGCFIV IDAMLERIKT EKTVDVYGHV TLMRSQRNYM VQTEDQYGFI
1610 1620 1630 1640 1650
HEALLEAVGC GNTEVPARSL YTYIQKLAQV EPGEHVTGME LEFKRLASSK
1660 1670 1680 1690 1700
AHTSRFITAS LPCNKFKNRL VNILPYESSR VCLQPIRGVE GSDYINASFI
1710 1720 1730 1740 1750
DGYRQQKAYI ATQGPLAETT EDFWRALWEN NSTIVVMLTK LREMGREKCH
1760 1770 1780 1790 1800
QYWPAERSAR YQYFVVDPMA EYNMPQYILR EFKVTDARDG QSRTVRQFQF
1810 1820 1830 1840 1850
TDWPEQGAPK SGEGFIDFIG QVHKTKEQFG QDGPISVHCS AGVGRTGVFI
1860 1870 1880 1890 1900
TLSIVLERMR YEGVVDIFQT VKVLRTQRPA MVQTEDEYQF CFQAALEYLG

SFDHYAT
Length:1,907
Mass (Da):211,904
Last modified:April 8, 2008 - v1
Checksum:i725C016196E22D1A
GO
Isoform 2 (identifier: B0V2N1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1519-1521: Missing.

Show »
Length:1,904
Mass (Da):211,579
Checksum:i276B40675B8B37FC
GO
Isoform 3 (identifier: B0V2N1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     604-604: K → I
     605-1010: Missing.

Show »
Length:1,501
Mass (Da):168,298
Checksum:i4443E1DDFE83BF41
GO
Isoform 4 (identifier: B0V2N1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     604-604: K → I
     605-1010: Missing.
     1284-1287: Missing.

Show »
Length:1,497
Mass (Da):167,871
Checksum:i07C97C891E1BE761
GO
Isoform 5 (identifier: B0V2N1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1315: Missing.

Show »
Length:592
Mass (Da):68,104
Checksum:iE24908FB00CE3F16
GO
Isoform 6 (identifier: B0V2N1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     624-669: Missing.

Show »
Length:1,861
Mass (Da):206,825
Checksum:i64C415721228AF18
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YDQ1A0A286YDQ1_MOUSE
Receptor-type tyrosine-protein phos...
Ptprs
48Annotation score:
A0A286YDF6A0A286YDF6_MOUSE
Receptor-type tyrosine-protein phos...
Ptprs
448Annotation score:
A0A286YDS2A0A286YDS2_MOUSE
Receptor-type tyrosine-protein phos...
Ptprs
208Annotation score:
A0A286YEA4A0A286YEA4_MOUSE
Receptor-type tyrosine-protein phos...
Ptprs
208Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti597R → H in CAA57732 (PubMed:7529177).Curated1
Sequence conflicti758P → A in CAA57732 (PubMed:7529177).Curated1
Sequence conflicti834A → G in CAA57732 (PubMed:7529177).Curated1
Sequence conflicti853A → R in CAA57732 (PubMed:7529177).Curated1
Sequence conflicti887A → G in CAA57732 (PubMed:7529177).Curated1
Sequence conflicti981A → G in CAA57732 (PubMed:7529177).Curated1
Sequence conflicti1169 – 1171RSL → QHV in CAA57732 (PubMed:7529177).Curated3
Sequence conflicti1502E → G in CAA57732 (PubMed:7529177).Curated1
Sequence conflicti1609G → S in CAA57732 (PubMed:7529177).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0360571 – 1315Missing in isoform 5. 1 PublicationAdd BLAST1315
Alternative sequenceiVSP_036058604K → I in isoform 3 and isoform 4. 1 Publication1
Alternative sequenceiVSP_036059605 – 1010Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST406
Alternative sequenceiVSP_036060624 – 669Missing in isoform 6. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_0360611284 – 1287Missing in isoform 4. 1 Publication4
Alternative sequenceiVSP_0360621519 – 1521Missing in isoform 2. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82288 mRNA Translation: CAA57732.1
D28530 mRNA Translation: BAA05886.1
AK159320 mRNA Translation: BAE34987.1
AK169714 mRNA Translation: BAE41325.1
CT009637 Genomic DNA No translation available.
BC052462 mRNA Translation: AAH52462.1
BC083188 mRNA Translation: AAH83188.1
CCDSiCCDS37664.1 [B0V2N1-1]
CCDS57103.1 [B0V2N1-3]
RefSeqiNP_001239382.1, NM_001252453.1 [B0V2N1-3]
NP_001239384.1, NM_001252455.1 [B0V2N1-4]
NP_001239385.1, NM_001252456.1 [B0V2N1-3]
NP_035348.2, NM_011218.2 [B0V2N1-1]
UniGeneiMm.258771

Genome annotation databases

EnsembliENSMUST00000067538; ENSMUSP00000064048; ENSMUSG00000013236 [B0V2N1-1]
ENSMUST00000086828; ENSMUSP00000084038; ENSMUSG00000013236 [B0V2N1-3]
ENSMUST00000223859; ENSMUSP00000153134; ENSMUSG00000013236 [B0V2N1-4]
GeneIDi19280
KEGGimmu:19280
UCSCiuc008dbx.3 mouse [B0V2N1-3]
uc008dby.2 mouse [B0V2N1-1]
uc008dca.2 mouse [B0V2N1-4]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82288 mRNA Translation: CAA57732.1
D28530 mRNA Translation: BAA05886.1
AK159320 mRNA Translation: BAE34987.1
AK169714 mRNA Translation: BAE41325.1
CT009637 Genomic DNA No translation available.
BC052462 mRNA Translation: AAH52462.1
BC083188 mRNA Translation: AAH83188.1
CCDSiCCDS37664.1 [B0V2N1-1]
CCDS57103.1 [B0V2N1-3]
RefSeqiNP_001239382.1, NM_001252453.1 [B0V2N1-3]
NP_001239384.1, NM_001252455.1 [B0V2N1-4]
NP_001239385.1, NM_001252456.1 [B0V2N1-3]
NP_035348.2, NM_011218.2 [B0V2N1-1]
UniGeneiMm.258771

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3SR9X-ray2.40A1326-1901[»]
ProteinModelPortaliB0V2N1
SMRiB0V2N1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202507, 3 interactors
IntActiB0V2N1, 5 interactors
STRINGi10090.ENSMUSP00000064048

PTM databases

iPTMnetiB0V2N1
PhosphoSitePlusiB0V2N1

Proteomic databases

MaxQBiB0V2N1
PaxDbiB0V2N1
PeptideAtlasiB0V2N1
PRIDEiB0V2N1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067538; ENSMUSP00000064048; ENSMUSG00000013236 [B0V2N1-1]
ENSMUST00000086828; ENSMUSP00000084038; ENSMUSG00000013236 [B0V2N1-3]
ENSMUST00000223859; ENSMUSP00000153134; ENSMUSG00000013236 [B0V2N1-4]
GeneIDi19280
KEGGimmu:19280
UCSCiuc008dbx.3 mouse [B0V2N1-3]
uc008dby.2 mouse [B0V2N1-1]
uc008dca.2 mouse [B0V2N1-4]

Organism-specific databases

CTDi5802
MGIiMGI:97815 Ptprs

Phylogenomic databases

eggNOGiKOG4228 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00760000118900
HOVERGENiHBG053758
InParanoidiB0V2N1
KOiK06778
OMAiGGTERCG
OrthoDBiEOG091G11WG
PhylomeDBiB0V2N1
TreeFamiTF312900

Enzyme and pathway databases

ReactomeiR-MMU-388844 Receptor-type tyrosine-protein phosphatases
R-MMU-8849932 Synaptic adhesion-like molecules

Miscellaneous databases

PROiPR:B0V2N1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000013236 Expressed in 305 organ(s), highest expression level in brain
ExpressionAtlasiB0V2N1 baseline and differential
GenevisibleiB0V2N1 MM

Family and domain databases

CDDicd00063 FN3, 7 hits
Gene3Di2.60.40.10, 11 hits
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00041 fn3, 6 hits
PF07679 I-set, 3 hits
PF00102 Y_phosphatase, 2 hits
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 8 hits
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
SSF49265 SSF49265, 5 hits
SSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 8 hits
PS50835 IG_LIKE, 3 hits
PS00383 TYR_PHOSPHATASE_1, 2 hits
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPTPRS_MOUSE
AccessioniPrimary (citable) accession number: B0V2N1
Secondary accession number(s): Q3TEC3
, Q3TXC9, Q4JFC7, Q5XJV4, Q64503, Q64699, Q7TT17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: April 8, 2008
Last modified: November 7, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again