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Entry version 91 (16 Oct 2019)
Sequence version 2 (03 Mar 2009)
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Protein

Condensin complex subunit 1

Gene

ncapd2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, DNA condensationUniRule annotation, MitosisUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Condensin complex subunit 1UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ncapd2Imported
Synonyms:si:ch73-60l17.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-050506-59 ncapd2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B0V123

PeptideAtlas

More...
PeptideAtlasi
B0V123

PRoteomics IDEntifications database

More...
PRIDEi
B0V123

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000005058 Expressed in 38 organ(s), highest expression level in multi-cellular organism

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
B0V123 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000103943

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini73 – 236Cnd1_NInterPro annotationAdd BLAST164
Domaini1058 – 1218Cnd1InterPro annotationAdd BLAST161

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni490 – 515DisorderedSequence analysisAdd BLAST26
Regioni571 – 597DisorderedSequence analysisAdd BLAST27
Regioni935 – 961DisorderedSequence analysisAdd BLAST27
Regioni1283 – 1380DisorderedSequence analysisAdd BLAST98

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi493 – 509AcidicSequence analysisAdd BLAST17
Compositional biasi1283 – 1298PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1299 – 1313PolarSequence analysisAdd BLAST15
Compositional biasi1319 – 1336PolyampholyteSequence analysisAdd BLAST18

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CND1 (condensin subunit 1) family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0414 Eukaryota
COG5098 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153566

KEGG Orthology (KO)

More...
KOi
K06677

Identification of Orthologs from Complete Genome Data

More...
OMAi
RNCVLQI

Database of Orthologous Groups

More...
OrthoDBi
166920at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B0V123

TreeFam database of animal gene trees

More...
TreeFami
TF105712

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR026971 CND1/NCAPD3
IPR032682 Cnd1_C
IPR007673 Condensin_cplx_su1
IPR024324 Condensin_cplx_su1_N

The PANTHER Classification System

More...
PANTHERi
PTHR14222 PTHR14222, 1 hit
PTHR14222:SF2 PTHR14222:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12717 Cnd1, 1 hit
PF12922 Cnd1_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF017127 Condensin_D2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

B0V123-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSWDFMVPVC LDDLVKSGAV NQYVVQDVLS AKQLPSHINS FKAAMRSQGP
60 70 80 90 100
LSILEHFDTA YSVLKHCRTV DVAVKEDILE LLIQVVRGLS VSLPTLLMAG
110 120 130 140 150
TLSAVDRKQQ LNAVKMSVFL LCKLTEMLES DSNRETIVTA PSKGRKKDKA
160 170 180 190 200
AGKDLLQWDS ERDTVLQCLT QLLQLDIRTL WSLSLVEEEF VSCVTCCCYK
210 220 230 240 250
LLENPTISHM KNKSTRDAII HVLGIMVKKY NHMLGACVKV IQLLQHFEQL
260 270 280 290 300
ASVCAQAVAA WSTEYGVKAI VGEIMREIGQ KSSEELAREG SGVKAFSSFL
310 320 330 340 350
SELGTLVPET MIPNISVLLT HLEGESPSLR VAVCEILGEV LVRVLSGDKL
360 370 380 390 400
DDSARASRDR FLDTLQEHIH DAHSHVRARV LQVYTRIVNS KALPLSRYTE
410 420 430 440 450
VMELTVGRLG DKSVNVCKSA IQLLAAFIAH NPYSCKLSSV DLKKPLEKEM
460 470 480 490 500
AKLKEMRDAQ AEQVPVAVIT ATDLWDAMKP EVELTVKALL EPGSEEEDDE
510 520 530 540 550
EEEEEAAEGD RSDRDTAVQI AQFLRESKYK KAVGLCMRAH SLFPESSFFS
560 570 580 590 600
DLADLNAESL INTLATLFKG PEEETPEAVS TDAPPTPQKE SEGRESELKK
610 620 630 640 650
QEMLVQYLKD TECFALQVER AIAVINNMLY WKTTTIVQEA VQFCVTAFEF
660 670 680 690 700
SVADSVCGVR KMLPLVWSTD VTIKDAVIQA YRRLYLNPNG ENTRAKAHTL
710 720 730 740 750
VDSLSDLMVD ASLGTIQCLE EIVQEFFSSE SALQTSVMQV LWERFSGKRE
760 770 780 790 800
TKALHRRAAV LLLGMAGRAE REVVLSNLDT LCSVALGEKV AEDYLLARDT
810 820 830 840 850
LITITNITDH VRQSKGVPFR LPMDHHLFSC LSQAIADGVV QSDPHWQTFM
860 870 880 890 900
EQAVRLIYFL AESPDQLCSR LLQRSARLLL EQITEGGEPD QSQLQEGASQ
910 920 930 940 950
VSEEQVNCVS LAQVLSLCGA VAFWQVSHLE RSVSSELRRR RGEKEEKEEK
960 970 980 990 1000
EKAPASKKGA NDSCVEEELG LVGASAEDTE AEFIRKICET ELLAEGNMLS
1010 1020 1030 1040 1050
AFLPLLVKVC SSPGKYSHPQ LTTAACLALS QYMMISPAVC KDHIRLLFTV
1060 1070 1080 1090 1100
LEKSQLPVVR ANTIVALGDL TVRFPNILEP WTPNLYARLS DENASVRLTA
1110 1120 1130 1140 1150
ITVLTQLVLK DVMKVKGQVS EVAVLLLDPE PHIASLALNF FNELSAKDNA
1160 1170 1180 1190 1200
IYNLLPDIIS RLSDPERGMN EEDFNTIMKQ LFSYITKERQ TESLVEKLCQ
1210 1220 1230 1240 1250
RFRTAKTERQ WADLAVSLSL LSVCERGFKK LQECWDCYSD KLAEPGVYQP
1260 1270 1280 1290 1300
LLSIAAKLRR RAKPQFKAQV EDYEKRLTAV HTKGLENVEN EEREQQADTQ
1310 1320 1330 1340 1350
SQNLHTPQAP KSVRRTTRGR GKPKVDDSDL VTPRKSRARP KPAITFTSDE
1360 1370 1380
EEEEDAVMAE SETPKVTTPI ARTRRTRLRH
Length:1,380
Mass (Da):154,176
Last modified:March 3, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8129F342525DCF9E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4IRW7A0A0R4IRW7_DANRE
Condensin complex subunit 1
ncapd2
1,404Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR788281 Genomic DNA No translation available.
CU467875 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001155974.2, NM_001162502.2
XP_005171438.1, XM_005171381.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000113351; ENSDARP00000103943; ENSDARG00000005058

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
552978

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:552978

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR788281 Genomic DNA No translation available.
CU467875 Genomic DNA No translation available.
RefSeqiNP_001155974.2, NM_001162502.2
XP_005171438.1, XM_005171381.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000103943

Proteomic databases

PaxDbiB0V123
PeptideAtlasiB0V123
PRIDEiB0V123

Genome annotation databases

EnsembliENSDART00000113351; ENSDARP00000103943; ENSDARG00000005058
GeneIDi552978
KEGGidre:552978

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9918
ZFINiZDB-GENE-050506-59 ncapd2

Phylogenomic databases

eggNOGiKOG0414 Eukaryota
COG5098 LUCA
GeneTreeiENSGT00940000153566
KOiK06677
OMAiRNCVLQI
OrthoDBi166920at2759
PhylomeDBiB0V123
TreeFamiTF105712

Gene expression databases

BgeeiENSDARG00000005058 Expressed in 38 organ(s), highest expression level in multi-cellular organism
ExpressionAtlasiB0V123 baseline and differential

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR026971 CND1/NCAPD3
IPR032682 Cnd1_C
IPR007673 Condensin_cplx_su1
IPR024324 Condensin_cplx_su1_N
PANTHERiPTHR14222 PTHR14222, 1 hit
PTHR14222:SF2 PTHR14222:SF2, 1 hit
PfamiView protein in Pfam
PF12717 Cnd1, 1 hit
PF12922 Cnd1_N, 1 hit
PIRSFiPIRSF017127 Condensin_D2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB0V123_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B0V123
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: March 3, 2009
Last modified: October 16, 2019
This is version 91 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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