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Entry version 78 (16 Jan 2019)
Sequence version 1 (08 Apr 2008)
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Protein
Submitted name:

Fas (TNFRSF6)-associated factor 1

Gene

faf1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • cartilage development Source: ZFIN
  • cell death Source: InterPro
  • pharyngeal system development Source: ZFIN

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Fas (TNFRSF6)-associated factor 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:faf1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-040426-2863 faf1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
B0UXY9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000022418 Expressed in 34 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
B0UXY9

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini127 – 196Ubiquitin-likeInterPro annotationAdd BLAST70
Domaini594 – 671UBXInterPro annotationAdd BLAST78

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili514 – 534Sequence analysisAdd BLAST21
Coiled coili550 – 576Sequence analysisAdd BLAST27

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPG5 Eukaryota
ENOG410Z9BT LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154831

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000043073

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG002876

KEGG Orthology (KO)

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KOi
K20703

Identification of Orthologs from Complete Genome Data

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OMAi
MEIFSAQ

Database of Orthologous Groups

More...
OrthoDBi
845154at2759

TreeFam database of animal gene trees

More...
TreeFami
TF314172

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01771 Faf1_UBX, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033043 FAF1_UBX
IPR036249 Thioredoxin-like_sf
IPR006577 UAS
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
IPR001012 UBX_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00789 UBX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00594 UAS, 1 hit
SM00166 UBX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52833 SSF52833, 1 hit
SSF54236 SSF54236, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit
PS50033 UBX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B0UXY9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASDSNMDRE MILADFQACT GIDNIAEAIT LLELNNWDLV AAINGVIPQE
60 70 80 90 100
NGILQSSFSS EASQTGPYGP HSQSEATAPT PSAPPPSASE SASASASSSS
110 120 130 140 150
SPPSSSSPAF CPVQPSRHIV ERQSRMLSFR VEYRQRSIEV VLEDASTVGE
160 170 180 190 200
IKTILETELQ VPVSKMQLKG WKSGDVSDST VLRSLHLPKN NSLYVLTPDI
210 220 230 240 250
APSASTSQSS AQQGLSNQNY LLVISHREAQ RDYSLNFPAS KTIQEVKRNI
260 270 280 290 300
SDLTNIPVRH QQWDGWPASA TDDSMTLAIS GISYPCHHLT VCRRSSPALT
310 320 330 340 350
VDQTDECTDV HMVSDSEGDD FEDAPEFGVD ESEIFGMGSS SCRKSPMMPE
360 370 380 390 400
NSENEGDALL HFTAEFSRRY GDCHPVFYIG SLEAASQEAF YGKARDRKLL
410 420 430 440 450
AIYLHNDESV LSNVFCSQMM CADSIVSYLS QNFITWAWDV TKEANKARLL
460 470 480 490 500
TMCTRHFGSV VAQTIRTYKT DQFPLLLIVM GKRTSNEVLN VIQGNTTVDE
510 520 530 540 550
LMMRLMGAME IFTAQQQEDI KDEDEREARE MVKREQDEAY RVSLEADRKK
560 570 580 590 600
REAQEREEAE QVRQERIRKE QEEEREAIRL SLEQALPPEP KEEGGEPISK
610 620 630 640 650
LRIRTPSGEF LERRFLGTCK LQVLFDFVAS KGYPSDEFKL LTTFPRRNIT
660 670
QLDPAWNLVE AKLFPQETLF LEAKE
Length:675
Mass (Da):75,554
Last modified:April 8, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0998EF95FBA3965C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR388216 Genomic DNA No translation available.
CU467870 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_998138.2, NM_212973.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Dr.75605

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000034004; ENSDARP00000037156; ENSDARG00000022418

Database of genes from NCBI RefSeq genomes

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GeneIDi
406243

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:406243

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR388216 Genomic DNA No translation available.
CU467870 Genomic DNA No translation available.
RefSeqiNP_998138.2, NM_212973.2
UniGeneiDr.75605

3D structure databases

ProteinModelPortaliB0UXY9
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiB0UXY9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000034004; ENSDARP00000037156; ENSDARG00000022418
GeneIDi406243
KEGGidre:406243

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11124
ZFINiZDB-GENE-040426-2863 faf1

Phylogenomic databases

eggNOGiENOG410IPG5 Eukaryota
ENOG410Z9BT LUCA
GeneTreeiENSGT00940000154831
HOGENOMiHOG000043073
HOVERGENiHBG002876
KOiK20703
OMAiMEIFSAQ
OrthoDBi845154at2759
TreeFamiTF314172

Gene expression databases

BgeeiENSDARG00000022418 Expressed in 34 organ(s), highest expression level in multi-cellular organism

Family and domain databases

CDDicd01771 Faf1_UBX, 1 hit
InterProiView protein in InterPro
IPR033043 FAF1_UBX
IPR036249 Thioredoxin-like_sf
IPR006577 UAS
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
IPR001012 UBX_dom
PfamiView protein in Pfam
PF00789 UBX, 1 hit
SMARTiView protein in SMART
SM00594 UAS, 1 hit
SM00166 UBX, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
SSF54236 SSF54236, 3 hits
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit
PS50033 UBX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB0UXY9_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B0UXY9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: January 16, 2019
This is version 78 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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