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Entry version 114 (07 Oct 2020)
Sequence version 1 (08 Apr 2008)
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Protein

Serine/threonine-protein kinase TOR

Gene

mtor

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotationARBA annotation, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-1257604, PIP3 activates AKT signaling
R-DRE-1632852, Macroautophagy
R-DRE-165159, MTOR signalling
R-DRE-166208, mTORC1-mediated signalling
R-DRE-3371571, HSF1-dependent transactivation
R-DRE-380972, Energy dependent regulation of mTOR by LKB1-AMPK
R-DRE-389357, CD28 dependent PI3K/Akt signaling
R-DRE-5218920, VEGFR2 mediated vascular permeability
R-DRE-5628897, TP53 Regulates Metabolic Genes
R-DRE-6804757, Regulation of TP53 Degradation
R-DRE-8943724, Regulation of PTEN gene transcription
R-DRE-9639288, Amino acids regulate mTORC1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase TORUniRule annotation (EC:2.7.11.1UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mtorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-2974, mtor

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B0UX67

PeptideAtlas

More...
PeptideAtlasi
B0UX67

PRoteomics IDEntifications database

More...
PRIDEi
B0UX67

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000053196, Expressed in camera-type eye and 36 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
B0UX67, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000105458

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1365 – 1948FATInterPro annotationAdd BLAST584
Domaini2148 – 2563PI3K/PI4KInterPro annotationAdd BLAST416
Domaini2531 – 2563FATCInterPro annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1792 – 1833DisorderedSequence analysisAdd BLAST42

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili661 – 681Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1806 – 1829PolarSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.UniRule annotationARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0891, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00930000151037

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B0UX67

Identification of Orthologs from Complete Genome Data

More...
OMAi
LNIQRYP

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B0UX67

TreeFam database of animal gene trees

More...
TreeFami
TF105134

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1070.11, 1 hit
1.20.120.150, 1 hit
1.25.10.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR024585, DUF3385_TOR
IPR003152, FATC_dom
IPR009076, FRB_dom
IPR036738, FRB_sf
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR003151, PIK-rel_kinase_FAT
IPR014009, PIK_FAT
IPR026683, TOR

The PANTHER Classification System

More...
PANTHERi
PTHR11139:SF9, PTHR11139:SF9, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11865, DUF3385, 1 hit
PF02259, FAT, 1 hit
PF02260, FATC, 1 hit
PF08771, FRB_dom, 1 hit
PF00454, PI3_PI4_kinase, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01346, DUF3385, 1 hit
SM01343, FATC, 1 hit
SM00146, PI3Kc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47212, SSF47212, 1 hit
SSF48371, SSF48371, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51189, FAT, 1 hit
PS51190, FATC, 1 hit
PS00915, PI3_4_KINASE_1, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

B0UX67-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGTATVLQQ FVSGLKSRNE DTRAKAAKDL QHYVTTELRE LSQDEATTFY
60 70 80 90 100
DELNHHIFEL VSSSDVNEKK GGILAIVSLI GVEGGNATRI SRFANYLRNL
110 120 130 140 150
LPSSDSVVME MASKAMGHLS MAGDTFTAEY VEFEVKRALE WLGADRNEGR
160 170 180 190 200
RHAAVLVLRE LAVSAPTFFF QQVQPFFDNI FYAVWDSKQA IREGAVSALR
210 220 230 240 250
ACLILTTQRE TKEMQKPQWY KQTFEEAEKG FDETLAKEKG MNKDDRVHGA
260 270 280 290 300
LLILNELVRI SSMEGERMRE EMEEITQQQL VHDKYCKELM GFSTKPRHIT
310 320 330 340 350
PFTSFQSVQP QQSNALLGLL GYSTPQGFLS FGAAPVPSKS TLVESRYCRE
360 370 380 390 400
LMEERFDQVC RWVLKYRTSK NPLIQMTILN LLPRLAAFQP HTFTDQYLQD
410 420 430 440 450
TMGHLLGCLK KEKERTAAFQ ALGLLVVAVR ADIQPYLSKI LEIIKAALPP
460 470 480 490 500
KDFAHKRQKT MQVDATVFTC ISMLSRAMGP SIQQDVKELL EPMLAVGLSP
510 520 530 540 550
ALTAVLYDLS RQIPQLKKDI QDGLLKMLSL VLMHKPLRHP GMPKGLAYQL
560 570 580 590 600
SSPSLTNIPE ASDVGSITLA LRTLGSFEFE GHSLTQFVRH CADHFLNSEH
610 620 630 640 650
KEIRMEAART CSRLLTPSIH LLSGHGHVVS QTAVQVVADV LSKLLVVGIT
660 670 680 690 700
DPDPDIRYCV LASLDERFDA HLAQAENLQA LFVALNDEVF EIRELAICTI
710 720 730 740 750
GRLSSMNPAF VMPFLRKMLI QILTELEHSG VGRNKEQSAR MLGHLVSNAP
760 770 780 790 800
RLIRPYMEPI LKALILKLKD PDPNPGVVIC VLATIGELAQ VSGLEMRKWM
810 820 830 840 850
DELFPIIMDM LQDSSSLAKR QVALWTLGQQ VASTGYVVEP YRKYPSLLEV
860 870 880 890 900
LLNFLKTEQN QGIRREAIRV LGLLGALDPY KHKVNIGMID QSRDASAVSL
910 920 930 940 950
SESKSSQDSA DYSTSEMLVN MGNLPLDEFY PAVAIVTLMR ILRDPSLSNH
960 970 980 990 1000
HTMVVQAVTF IFKSLGLKCV QFLPQVMPTF LNVIRVCDAS IREFLFQQMG
1010 1020 1030 1040 1050
MVVCFVKIHI RPYMDDIFTL IREYWTPNNP MQNTIILLIE QIVVALGGEF
1060 1070 1080 1090 1100
KLYLPQLIPH MLRVFMHDMS VGRNVTIKLL MAIQLFGANL DDYLHLLLPP
1110 1120 1130 1140 1150
VVKLFDAPDV PLQARKVALE TLDRLTESLD FTDYASRIIH PIVRTLDVTP
1160 1170 1180 1190 1200
ELRNSSMDTL SSLVFQLGKK YQIFIPMVNK VMLKHRINHQ RYDVLICRIV
1210 1220 1230 1240 1250
KGYTLAEEEE DPLIFQHRQL RSSQSDTLVS GPVESGPMKK LHVSTTALQK
1260 1270 1280 1290 1300
AWGAARKVSK DDWLEWLRRL SVVLLKESSS PALRSCWSLA QTYIPLARDL
1310 1320 1330 1340 1350
FNAAFLSCWS ELSEDQQDEL IRSIELALTS QDIAEVTQTL LNLAEFMEHS
1360 1370 1380 1390 1400
DKGPLPLRDD NGIVLLGERA AKCRAYAKAL HYKELEFQKG ASPLILESLI
1410 1420 1430 1440 1450
SINNKLQQPE AASGVLEYAM KHFGELEIQA TWYEKLHEWE DALVAYDKKI
1460 1470 1480 1490 1500
DMNKDDPELI LGRMRCLEAL GEWGQLHQQC CEEWTLVSEE TQAKMARMAA
1510 1520 1530 1540 1550
AAAWGLGHWD SMEEYTCMIP RDTHDGAFYR AVLALHQDLF SLAQQCIDKA
1560 1570 1580 1590 1600
RDLLDAELTA MAGESYSRAY GAMVSCQMLS ELEEVIQYKL VPERRDIIRE
1610 1620 1630 1640 1650
TWWERLQGCQ RIVEDWQRIL MVRSLVINPH EDMRTWLKYA SLCGKSGRLA
1660 1670 1680 1690 1700
LAHKTLVLLL GVDPSKQLDH PLPTAHPHVT YAYMKYMWKS TRKIDAFQHM
1710 1720 1730 1740 1750
QHFVQGMQQQ AQHAIAAEDQ QHKLELHKLM ARCFLKLGEW QLSLQGINES
1760 1770 1780 1790 1800
TIPKVLQYYS HSTEHDRNWY KAWHAWAVMN FEAVLHYKHQ NQGRDEKKKL
1810 1820 1830 1840 1850
RHASGASANS EASNSDSEAD STEHSPVPSP GQKKVNEDLS KTLLLYTVPA
1860 1870 1880 1890 1900
VQGFFRSISL SRGNNLQDTL RVLTLWFDYG HWPEVNEALV EGIKTIQIDT
1910 1920 1930 1940 1950
WLQVIPQLIA RIDTPRALVG RLIHQLLTDI GRYHPQALIY PLTVASKSTT
1960 1970 1980 1990 2000
TARHNAANKI LKNMCEHCNT LVQQAIMVSE ELIRVAILWH EMWHEGLEEA
2010 2020 2030 2040 2050
SRLYFGERNV KGMFAVLEPL HAMMERGPQT LKETSFNQAY GRDLMEAQDW
2060 2070 2080 2090 2100
CRKYMRSGNV KDLTQAWDLY YHVFRRISKQ LPQLTSLELQ YVSPKLLMCR
2110 2120 2130 2140 2150
DLELAVPGTY DPNQSIIRIQ SIAPSLQVIT SKQRPRKLTI MGSNGHEFMF
2160 2170 2180 2190 2200
LLKGHEDLRQ DERVMQLFGL VNTLLANDPA SLRKNLRQVS CVHVSEHCRI
2210 2220 2230 2240 2250
SDVLISLQHI IIQRYAVIPL STNSGLIGWV PHCDTLHALI RDYREKKKIL
2260 2270 2280 2290 2300
LNIEHRIMLR MAPDYDHLTL MEKVEVFEHA VNNTAGDDLA KLLWLKSPSS
2310 2320 2330 2340 2350
EVWFDRRTNY TRSLAVMSMV GYILGLGDRH PSNLMLDRLS GKILHIDFGD
2360 2370 2380 2390 2400
CFEVAMTREK FPEKIPFRLT RMLTNAMEVT GLDGNYRITC HTVMEVLREH
2410 2420 2430 2440 2450
RDSVMAVLEA FVYDPLLNWR LMDTNTKGNK RSRTRTDSYT AGQSVEFPSK
2460 2470 2480 2490 2500
LTFLEIDTFL WYVFGMFRVE AMEGIDLGET THKKPGTTVP ESIHSFIGDG
2510 2520 2530 2540 2550
LVQPEALNKK AIQIINRVRD KLTGRDFSHD ETLDVPTQVE LLIKQATSHE
2560
NLCQCYIGWC PFW
Length:2,563
Mass (Da):291,876
Last modified:April 8, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFE3C706ADD3B8BDE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1Q9H9F1Q9H9_DANRE
Serine/threonine-protein kinase TOR
mtor
2,515Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR354389 Genomic DNA No translation available.
CR354402 Genomic DNA No translation available.
CR450703 Genomic DNA No translation available.
CT025740 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000122801; ENSDARP00000105458; ENSDARG00000053196

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR354389 Genomic DNA No translation available.
CR354402 Genomic DNA No translation available.
CR450703 Genomic DNA No translation available.
CT025740 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000105458

Proteomic databases

PaxDbiB0UX67
PeptideAtlasiB0UX67
PRIDEiB0UX67

Genome annotation databases

EnsembliENSDART00000122801; ENSDARP00000105458; ENSDARG00000053196

Organism-specific databases

ZFINiZDB-GENE-030131-2974, mtor

Phylogenomic databases

eggNOGiKOG0891, Eukaryota
GeneTreeiENSGT00930000151037
InParanoidiB0UX67
OMAiLNIQRYP
PhylomeDBiB0UX67
TreeFamiTF105134

Enzyme and pathway databases

ReactomeiR-DRE-1257604, PIP3 activates AKT signaling
R-DRE-1632852, Macroautophagy
R-DRE-165159, MTOR signalling
R-DRE-166208, mTORC1-mediated signalling
R-DRE-3371571, HSF1-dependent transactivation
R-DRE-380972, Energy dependent regulation of mTOR by LKB1-AMPK
R-DRE-389357, CD28 dependent PI3K/Akt signaling
R-DRE-5218920, VEGFR2 mediated vascular permeability
R-DRE-5628897, TP53 Regulates Metabolic Genes
R-DRE-6804757, Regulation of TP53 Degradation
R-DRE-8943724, Regulation of PTEN gene transcription
R-DRE-9639288, Amino acids regulate mTORC1

Gene expression databases

BgeeiENSDARG00000053196, Expressed in camera-type eye and 36 other tissues
ExpressionAtlasiB0UX67, baseline and differential

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
1.20.120.150, 1 hit
1.25.10.10, 4 hits
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR024585, DUF3385_TOR
IPR003152, FATC_dom
IPR009076, FRB_dom
IPR036738, FRB_sf
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR003151, PIK-rel_kinase_FAT
IPR014009, PIK_FAT
IPR026683, TOR
PANTHERiPTHR11139:SF9, PTHR11139:SF9, 1 hit
PfamiView protein in Pfam
PF11865, DUF3385, 1 hit
PF02259, FAT, 1 hit
PF02260, FATC, 1 hit
PF08771, FRB_dom, 1 hit
PF00454, PI3_PI4_kinase, 2 hits
SMARTiView protein in SMART
SM01346, DUF3385, 1 hit
SM01343, FATC, 1 hit
SM00146, PI3Kc, 1 hit
SUPFAMiSSF47212, SSF47212, 1 hit
SSF48371, SSF48371, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51189, FAT, 1 hit
PS51190, FATC, 1 hit
PS00915, PI3_4_KINASE_1, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB0UX67_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B0UX67
Secondary accession number(s): E7F5U1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: October 7, 2020
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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