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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Heliobacterium modesticaldum (strain ATCC 51547 / Ice1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei49Nucleophile; for GATase activityUniRule annotation1
Active sitei650For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotationImported, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotationSAAS annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotationImported
ORF Names:HM1_1526Imported
OrganismiHeliobacterium modesticaldum (strain ATCC 51547 / Ice1)Imported
Taxonomic identifieri498761 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesHeliobacteriaceaeHeliobacterium
Proteomesi
  • UP000008550 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi498761.HM1_1526

Structurei

3D structure databases

ProteinModelPortaliB0TCS2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 264Glutamine amidotransferase type-2InterPro annotationAdd BLAST216
Domaini331 – 471SISInterPro annotationAdd BLAST141
Domaini504 – 645SISInterPro annotationAdd BLAST142

Phylogenomic databases

eggNOGiENOG4105C46 Bacteria
COG0449 LUCA
HOGENOMiHOG000258896
KOiK00820
OMAiASEYRYA
OrthoDBiPOG091H0061

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B0TCS2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPFGRQHFRE KKHESGGFFA PIFRVELFLV KGRHSIRPMI EERRNHPMCG
60 70 80 90 100
IVGYIGGKAA APILVEGLKK LEYRGYDSAG VAVMEAGKIE VRKAKGKLAV
110 120 130 140 150
LEGRLSYCSF GAQTGIGHTR WATHGKPADE NAHPHQDCRG DFAVVHNGII
160 170 180 190 200
ENFQTLKEDL IAQGHAFTSE TDTEVLAHLV ENFYQGDLEA AVRKVVSVIE
210 220 230 240 250
GSYAMAFLCR HEPEKIVAVR KDSPLVVGLG DGEYFLASDI PAILAHTRRT
260 270 280 290 300
FILDDGEMAV LTPQGAVIKT AAAGELVDKA VFEVNWDAVA AEKGGYDHFM
310 320 330 340 350
IKEIYEQPKA LRDTILGRVN GDGVNLSEIK IDLELLKKTN KVTIVACGTA
360 370 380 390 400
YHAGLVGKYV IEDLARVPVE VDIASEFRYR DPIVDENTLV IVVSQSGETA
410 420 430 440 450
DTLAAMREAR SKGAKVLAVT NVVGSTISRE ADSVLYTWAG PEIAVASTKA
460 470 480 490 500
YTTQLAAMNC IALALAQVRG TQSAETIKAI ADAIREIPAQ VEKVLAQAET
510 520 530 540 550
VKAISEQIKT WDDVFFIGRS VDYAVALEGS LKLKEISYIH AEAYAAGELK
560 570 580 590 600
HGTLALITDN IPVIALATQE QVFDKTISNI QEVKARDAFV IAVAQEGNRE
610 620 630 640 650
IAKFAEYVLT IPRTHPALAP ILAVVPLQML SYYTAVAREC DVDKPRNLAK

SVTVE
Length:655
Mass (Da):71,362
Last modified:April 8, 2008 - v1
Checksum:i12AB2497FD0C1351
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000930 Genomic DNA Translation: ABZ84098.1

Genome annotation databases

EnsemblBacteriaiABZ84098; ABZ84098; HM1_1526
KEGGihmo:HM1_1526

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000930 Genomic DNA Translation: ABZ84098.1

3D structure databases

ProteinModelPortaliB0TCS2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi498761.HM1_1526

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABZ84098; ABZ84098; HM1_1526
KEGGihmo:HM1_1526

Phylogenomic databases

eggNOGiENOG4105C46 Bacteria
COG0449 LUCA
HOGENOMiHOG000258896
KOiK00820
OMAiASEYRYA
OrthoDBiPOG091H0061

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiB0TCS2_HELMI
AccessioniPrimary (citable) accession number: B0TCS2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: November 22, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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