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Entry version 70 (26 Feb 2020)
Sequence version 1 (08 Apr 2008)
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Protein

D-mannonate dehydratase Caul1427

Gene

Caul_1427

Organism
Caulobacter sp. (strain K31)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the dehydration of D-mannonate. Has no detectable activity with a panel of 70 other acid sugars (in vitro).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 PublicationNote: Binds 1 Mg2+ ion per subunit.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 2.0 sec(-1) with D-mannonate.1 Publication

      <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: pentose and glucuronate interconversion

      This protein is involved in the pathway pentose and glucuronate interconversion, which is part of Carbohydrate metabolism.
      View all proteins of this organism that are known to be involved in the pathway pentose and glucuronate interconversion and in Carbohydrate metabolism.

      Sites

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei38SubstrateBy similarity1
      Binding sitei123SubstrateBy similarity1
      <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei160Proton donor/acceptorBy similarity1
      <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi211Magnesium1 Publication1
      Active sitei213Proton donor/acceptorBy similarity1
      Metal bindingi237Magnesium1 Publication1
      Metal bindingi263Magnesium1 Publication1
      Binding sitei263SubstrateBy similarity1
      Binding sitei284SubstrateBy similarity1
      Binding sitei313SubstrateBy similarity1
      <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei315Important for activity and substrate specificity; Ala is observed in family members with high D-mannonate dehydratase activity that have no activity with D-gluconateBy similarity1
      Binding sitei317SubstrateBy similarity1
      Binding sitei340SubstrateBy similarity1

      <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

      GO - Biological processi

      <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

      Molecular functionLyase
      Biological processCarbohydrate metabolism
      LigandMagnesium, Metal-binding

      Enzyme and pathway databases

      BioCyc Collection of Pathway/Genome Databases

      More...
      BioCyci
      CSP366602:GH0Y-1432-MONOMER

      UniPathway: a resource for the exploration and annotation of metabolic pathways

      More...
      UniPathwayi
      UPA00246

      <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
      Recommended name:
      D-mannonate dehydratase Caul1427 (EC:4.2.1.8)
      Short name:
      ManD
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
      Ordered Locus Names:Caul_1427
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaulobacter sp. (strain K31)
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri366602 [NCBI]
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacterunclassified Caulobacter
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
      • UP000001316 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

      <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

      Molecule processing

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004298761 – 403D-mannonate dehydratase Caul1427Add BLAST403

      <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

      Protein-protein interaction databases

      STRING: functional protein association networks

      More...
      STRINGi
      366602.Caul_1427

      <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

      Secondary structure

      1403
      Legend: HelixTurnBeta strandPDB Structure known for this area
      Show more details

      3D structure databases

      SWISS-MODEL Repository - a database of annotated 3D protein structure models

      More...
      SMRi
      B0T0B1

      Database of comparative protein structure models

      More...
      ModBasei
      Search...

      Protein Data Bank in Europe - Knowledge Base

      More...
      PDBe-KBi
      Search...

      <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

      <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

      Phylogenomic databases

      evolutionary genealogy of genes: Non-supervised Orthologous Groups

      More...
      eggNOGi
      ENOG4105CXK Bacteria
      COG4948 LUCA

      The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

      More...
      HOGENOMi
      CLU_030273_6_1_5

      KEGG Orthology (KO)

      More...
      KOi
      K08323

      Identification of Orthologs from Complete Genome Data

      More...
      OMAi
      DWDTRAY

      Database of Orthologous Groups

      More...
      OrthoDBi
      1825548at2

      Family and domain databases

      Gene3D Structural and Functional Annotation of Protein Families

      More...
      Gene3Di
      3.20.20.120, 1 hit
      3.30.390.10, 1 hit

      Integrated resource of protein families, domains and functional sites

      More...
      InterProi
      View protein in InterPro
      IPR034589 D-mannonate_dehydratase-like
      IPR036849 Enolase-like_C_sf
      IPR029017 Enolase-like_N
      IPR029065 Enolase_C-like
      IPR018110 Mandel_Rmase/mucon_lact_enz_CS
      IPR034593 Mandelate_racemase-like
      IPR013342 Mandelate_racemase_C
      IPR013341 Mandelate_racemase_N_dom

      The PANTHER Classification System

      More...
      PANTHERi
      PTHR43287 PTHR43287, 1 hit
      PTHR43287:SF3 PTHR43287:SF3, 1 hit

      Pfam protein domain database

      More...
      Pfami
      View protein in Pfam
      PF13378 MR_MLE_C, 1 hit
      PF02746 MR_MLE_N, 1 hit

      Structure-Function Linkage Database

      More...
      SFLDi
      SFLDG00033 mannonate_dehydratase, 1 hit

      Simple Modular Architecture Research Tool; a protein domain database

      More...
      SMARTi
      View protein in SMART
      SM00922 MR_MLE, 1 hit

      Superfamily database of structural and functional annotation

      More...
      SUPFAMi
      SSF51604 SSF51604, 1 hit
      SSF54826 SSF54826, 1 hit

      PROSITE; a protein domain and family database

      More...
      PROSITEi
      View protein in PROSITE
      PS00908 MR_MLE_1, 1 hit

      <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

      <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

      B0T0B1-1 [UniParc]FASTAAdd to basket
      « Hide
              10         20         30         40         50
      MLKIIDAKVI VTCPGRNFVT LKITTSDGVT GVGDATLNGR ELAVVSYLRD
      60 70 80 90 100
      HMIPCLIGRD AHRIEDVWQF FYRGSYWRGG PVAMTALAAV DMALWDIKAK
      110 120 130 140 150
      LAGMPLYQLL GGACREGVMV YGHANGETIE DTIAEARKYQ ALGYKAIRLQ
      160 170 180 190 200
      SGVPGLPSTY GVSGDKMFYE PADGNLPTEN VWSTSKYLKH APKLFEAARE
      210 220 230 240 250
      ALGDDVHLLH DVHHRLTPIE AGRLGKDLEP YRLFWLEDAV PAENQAGFRL
      260 270 280 290 300
      IRQHTTTPLA VGEIFSHVWD CKQLIEEQLI DYLRATVLHA GGITNLRKIA
      310 320 330 340 350
      AFADLHHVRT GCHGATDLSP ITMAAALHFD LSVSNFGLQE YMRHTPETDA
      360 370 380 390 400
      VFPHAYSYKD GMLHPGEAPG LGVDIDEALA GQYPYKRAYL PVNRLEDGTM

      YNW
      Length:403
      Mass (Da):44,661
      Last modified:April 8, 2008 - v1
      <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF537D42E106B83A3
      GO

      Sequence databases

      Select the link destinations:

      EMBL nucleotide sequence database

      More...
      EMBLi

      GenBank nucleotide sequence database

      More...
      GenBanki

      DNA Data Bank of Japan; a nucleotide sequence database

      More...
      DDBJi
      Links Updated
      CP000927 Genomic DNA Translation: ABZ70557.1

      NCBI Reference Sequences

      More...
      RefSeqi
      WP_012285484.1, NC_010338.1

      Genome annotation databases

      Ensembl bacterial and archaeal genome annotation project

      More...
      EnsemblBacteriai
      ABZ70557; ABZ70557; Caul_1427

      KEGG: Kyoto Encyclopedia of Genes and Genomes

      More...
      KEGGi
      cak:Caul_1427

      <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

      <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

      Sequence databases

      Select the link destinations:
      EMBLi
      GenBanki
      DDBJi
      Links Updated
      CP000927 Genomic DNA Translation: ABZ70557.1
      RefSeqiWP_012285484.1, NC_010338.1

      3D structure databases

      Select the link destinations:

      Protein Data Bank Europe

      More...
      PDBei

      Protein Data Bank RCSB

      More...
      RCSB PDBi

      Protein Data Bank Japan

      More...
      PDBji
      Links Updated
      PDB entryMethodResolution (Å)ChainPositionsPDBsum
      4FI4X-ray2.00A/B/C1-403[»]
      SMRiB0T0B1
      ModBaseiSearch...
      PDBe-KBiSearch...

      Protein-protein interaction databases

      STRINGi366602.Caul_1427

      Genome annotation databases

      EnsemblBacteriaiABZ70557; ABZ70557; Caul_1427
      KEGGicak:Caul_1427

      Phylogenomic databases

      eggNOGiENOG4105CXK Bacteria
      COG4948 LUCA
      HOGENOMiCLU_030273_6_1_5
      KOiK08323
      OMAiDWDTRAY
      OrthoDBi1825548at2

      Enzyme and pathway databases

      UniPathwayiUPA00246
      BioCyciCSP366602:GH0Y-1432-MONOMER

      Family and domain databases

      Gene3Di3.20.20.120, 1 hit
      3.30.390.10, 1 hit
      InterProiView protein in InterPro
      IPR034589 D-mannonate_dehydratase-like
      IPR036849 Enolase-like_C_sf
      IPR029017 Enolase-like_N
      IPR029065 Enolase_C-like
      IPR018110 Mandel_Rmase/mucon_lact_enz_CS
      IPR034593 Mandelate_racemase-like
      IPR013342 Mandelate_racemase_C
      IPR013341 Mandelate_racemase_N_dom
      PANTHERiPTHR43287 PTHR43287, 1 hit
      PTHR43287:SF3 PTHR43287:SF3, 1 hit
      PfamiView protein in Pfam
      PF13378 MR_MLE_C, 1 hit
      PF02746 MR_MLE_N, 1 hit
      SFLDiSFLDG00033 mannonate_dehydratase, 1 hit
      SMARTiView protein in SMART
      SM00922 MR_MLE, 1 hit
      SUPFAMiSSF51604 SSF51604, 1 hit
      SSF54826 SSF54826, 1 hit
      PROSITEiView protein in PROSITE
      PS00908 MR_MLE_1, 1 hit

      ProtoNet; Automatic hierarchical classification of proteins

      More...
      ProtoNeti
      Search...

      MobiDB: a database of protein disorder and mobility annotations

      More...
      MobiDBi
      Search...

      <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

      <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAND1_CAUSK
      <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B0T0B1
      <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 9, 2014
      Last sequence update: April 8, 2008
      Last modified: February 26, 2020
      This is version 70 of the entry and version 1 of the sequence. See complete history.
      <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
      Annotation programProkaryotic Protein Annotation Program

      <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

      Keywords - Technical termi

      3D-structure

      Documents

      1. PATHWAY comments
        Index of metabolic and biosynthesis pathways
      2. PDB cross-references
        Index of Protein Data Bank (PDB) cross-references
      3. SIMILARITY comments
        Index of protein domains and families
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