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Protein

Triosephosphate isomerase

Gene

tpiA

Organism
Leptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).UniRule annotation

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Triosephosphate isomerase (tpiA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei94ElectrophileUniRule annotation1
Active sitei166Proton acceptorUniRule annotation1
Binding sitei172Substrate; via amide nitrogenUniRule annotation1
Binding sitei214SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00189

UPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomeraseUniRule annotation (EC:5.3.1.1UniRule annotation)
Short name:
TIMUniRule annotation
Short name:
TPIUniRule annotation
Alternative name(s):
Triose-phosphate isomeraseUniRule annotation
Gene namesi
Name:tpiAUniRule annotation
Ordered Locus Names:LEPBI_I2082
OrganismiLeptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris)
Taxonomic identifieri456481 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesLeptospiralesLeptospiraceaeLeptospira
Proteomesi
  • UP000001847 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000965091 – 249Triosephosphate isomeraseAdd BLAST249

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi456481.LEPBI_I2082

Structurei

3D structure databases

ProteinModelPortaliB0SSU4
SMRiB0SSU4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni9 – 11Substrate bindingUniRule annotation3
Regioni235 – 236Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CP7 Bacteria
COG0149 LUCA
HOGENOMiHOG000226413
KOiK01803
OMAiLCVGEGL
OrthoDBiPOG091H02GL

Family and domain databases

CDDicd00311 TIM, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00147_B TIM_B, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR035990 TIM_sf
IPR022896 TrioseP_Isoase_bac/euk
IPR000652 Triosephosphate_isomerase
IPR020861 Triosephosphate_isomerase_AS
PANTHERiPTHR21139 PTHR21139, 1 hit
PfamiView protein in Pfam
PF00121 TIM, 1 hit
SUPFAMiSSF51351 SSF51351, 1 hit
TIGRFAMsiTIGR00419 tim, 1 hit
PROSITEiView protein in PROSITE
PS00171 TIM_1, 1 hit
PS51440 TIM_2, 1 hit

Sequencei

Sequence statusi: Complete.

B0SSU4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKKIIAGNW KMNLTLAEAK EITKGLLSAC DSSSYEIMVF PSALHLESVA
60 70 80 90 100
SIARDSQLIV GAQNAYQSGL TAMTGEISPV QLAELGIQTV LVGHSERRQF
110 120 130 140 150
LGETSEFDNT KISYFLKHGL RVVYCVGETW AEREKGNTFS VLEDQIGKGL
160 170 180 190 200
KGITSDLFKN LVIAYEPVWA IGTGKVATPV EAEEAHAFIR KEIGKLFVGA
210 220 230 240
DLVAENIQIL YGGSVKPDNI KELLAKPNID GGLVGGASQK LDLFLGLLK
Length:249
Mass (Da):26,969
Last modified:April 8, 2008 - v1
Checksum:iA3F9612D142C44C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000786 Genomic DNA Translation: ABZ98184.1
RefSeqiWP_012389054.1, NC_010602.1

Genome annotation databases

EnsemblBacteriaiABZ98184; ABZ98184; LEPBI_I2082
GeneIDi35830941
KEGGilbi:LEPBI_I2082

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000786 Genomic DNA Translation: ABZ98184.1
RefSeqiWP_012389054.1, NC_010602.1

3D structure databases

ProteinModelPortaliB0SSU4
SMRiB0SSU4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi456481.LEPBI_I2082

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABZ98184; ABZ98184; LEPBI_I2082
GeneIDi35830941
KEGGilbi:LEPBI_I2082

Phylogenomic databases

eggNOGiENOG4105CP7 Bacteria
COG0149 LUCA
HOGENOMiHOG000226413
KOiK01803
OMAiLCVGEGL
OrthoDBiPOG091H02GL

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00189

UPA00138

Family and domain databases

CDDicd00311 TIM, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00147_B TIM_B, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR035990 TIM_sf
IPR022896 TrioseP_Isoase_bac/euk
IPR000652 Triosephosphate_isomerase
IPR020861 Triosephosphate_isomerase_AS
PANTHERiPTHR21139 PTHR21139, 1 hit
PfamiView protein in Pfam
PF00121 TIM, 1 hit
SUPFAMiSSF51351 SSF51351, 1 hit
TIGRFAMsiTIGR00419 tim, 1 hit
PROSITEiView protein in PROSITE
PS00171 TIM_1, 1 hit
PS51440 TIM_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTPIS_LEPBP
AccessioniPrimary (citable) accession number: B0SSU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 8, 2008
Last modified: October 10, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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