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Protein

LL-diaminopimelate aminotransferase

Gene

dapL

Organism
Leptospira biflexa serovar Patoc (strain Patoc 1 / Ames)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. LL-diaminopimelate aminotransferase (dapL)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route), the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei15SubstrateUniRule annotation1
Binding sitei42Substrate; via amide nitrogenUniRule annotation1
Binding sitei72Pyridoxal phosphateUniRule annotation1
Binding sitei109SubstrateUniRule annotation1
Binding sitei132Pyridoxal phosphateUniRule annotation1
Binding sitei132SubstrateUniRule annotation1
Binding sitei187Pyridoxal phosphateUniRule annotation1
Binding sitei187SubstrateUniRule annotation1
Binding sitei218Pyridoxal phosphateUniRule annotation1
Binding sitei257Pyridoxal phosphateUniRule annotation1
Binding sitei292Pyridoxal phosphateUniRule annotation1
Binding sitei292SubstrateUniRule annotation1
Binding sitei388SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayi
UPA00034;UER00466

Names & Taxonomyi

Protein namesi
Recommended name:
LL-diaminopimelate aminotransferaseUniRule annotation (EC:2.6.1.83UniRule annotation)
Short name:
DAP-ATUniRule annotation
Short name:
DAP-aminotransferaseUniRule annotation
Short name:
LL-DAP-aminotransferaseUniRule annotation
Gene namesi
Name:dapLUniRule annotation
Ordered Locus Names:LBF_0994
OrganismiLeptospira biflexa serovar Patoc (strain Patoc 1 / Ames)
Taxonomic identifieri355278 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesLeptospiralesLeptospiraceaeLeptospira

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003422441 – 408LL-diaminopimelate aminotransferaseAdd BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei249N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB0SEH8
SMRiB0SEH8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni108 – 109Pyridoxal phosphate bindingUniRule annotation2
Regioni246 – 248Pyridoxal phosphate bindingUniRule annotation3

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000223061
KOiK10206
OMAiTGTRCAF
OrthoDBiPOG091H0235

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01642 DapL_aminotrans_1, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR019942 DapL/ALD1
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR43144 PTHR43144, 1 hit
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR03542 DAPAT_plant, 1 hit

Sequencei

Sequence statusi: Complete.

B0SEH8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTQINENYLK LKAGYLFPEI GRRVKAYSDA NQNAKIIRLG IGDVTLPLAP
60 70 80 90 100
TIVNAMVDAA KEMGSAGGFH GYGPEQGYSF LIQKIIAHDY TARGVQIAED
110 120 130 140 150
EVFVSDGSKC DCGNIQEIFS LDSKIAVVDP VYPVYVDTNV MAGRTGEVGP
160 170 180 190 200
DGRYANIVYM PATEENNFEP DFPKEKADII YLCYPNNPTG MVATKARLTE
210 220 230 240 250
WVNYAKKMGS IILYDSAYES FIQDPEIPKS IYEIPGAKEV AMEFRSFSKT
260 270 280 290 300
AGFTGTRCAY LVIPKDLKGK TKSGEEVSFN SLWNRRHTTK FNGVSYITQK
310 320 330 340 350
GAEAVFSAQG QVEIKEQISY YMENAKLIRE GLVKAGYTVF GGTNAPYIWL
360 370 380 390 400
KTPRGLKSWE FFDELLGTAQ VVGTPGSGFG PAGEGYFRLS AFGKREDVIS

AIERIQKM
Length:408
Mass (Da):45,075
Last modified:April 8, 2008 - v1
Checksum:i0395E8398D67AB31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000777 Genomic DNA Translation: ABZ93521.1
RefSeqiWP_012388033.1, NC_010842.1

Genome annotation databases

EnsemblBacteriaiABZ93521; ABZ93521; LBF_0994
GeneIDi35832599
KEGGilbf:LBF_0994

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000777 Genomic DNA Translation: ABZ93521.1
RefSeqiWP_012388033.1, NC_010842.1

3D structure databases

ProteinModelPortaliB0SEH8
SMRiB0SEH8
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABZ93521; ABZ93521; LBF_0994
GeneIDi35832599
KEGGilbf:LBF_0994

Phylogenomic databases

HOGENOMiHOG000223061
KOiK10206
OMAiTGTRCAF
OrthoDBiPOG091H0235

Enzyme and pathway databases

UniPathwayi
UPA00034;UER00466

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01642 DapL_aminotrans_1, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR019942 DapL/ALD1
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR43144 PTHR43144, 1 hit
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR03542 DAPAT_plant, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDAPAT_LEPBA
AccessioniPrimary (citable) accession number: B0SEH8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: April 8, 2008
Last modified: October 10, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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