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Entry version 83 (26 Feb. 2020)
Sequence version 1 (08 Apr. 2008)
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Protein
Submitted name:

Cell division cycle 16 homolog (S. cerevisiae)

Gene

cdc16

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
R-DRE-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-DRE-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DRE-174154 APC/C:Cdc20 mediated degradation of Securin
R-DRE-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DRE-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DRE-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-DRE-176408 Regulation of APC/C activators between G1/S and early anaphase
R-DRE-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
R-DRE-176412 Phosphorylation of the APC/C
R-DRE-179409 APC-Cdc20 mediated degradation of Nek2A
R-DRE-2467813 Separation of Sister Chromatids
R-DRE-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-DRE-69017 CDK-mediated phosphorylation and removal of Cdc6
R-DRE-983168 Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cell division cycle 16 homolog (S. cerevisiae)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cdc16Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-051113-132 cdc16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B0S729

PeptideAtlas

More...
PeptideAtlasi
B0S729

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000055470 Expressed in multi-cellular organism and 20 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
B0S729 baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000072280

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati130 – 163TPRPROSITE-ProRule annotationAdd BLAST34
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini300 – 513TPR_REGIONInterPro annotationAdd BLAST214
Repeati335 – 368TPRPROSITE-ProRule annotationAdd BLAST34
Repeati369 – 402TPRPROSITE-ProRule annotationAdd BLAST34
Repeati446 – 479TPRPROSITE-ProRule annotationAdd BLAST34
Repeati480 – 513TPRPROSITE-ProRule annotationAdd BLAST34

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

TPR repeatPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1173 Eukaryota
ENOG410XNY1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182950

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011751_3_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B0S729

Identification of Orthologs from Complete Genome Data

More...
OMAi
QFIDMRR

TreeFam database of animal gene trees

More...
TreeFami
TF101054

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028 TPR, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005 TPR, 5 hits
PS50293 TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

B0S729-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLDRLRKRV RHYIDQQQYQ SALFWADKIA SLSHEDPQDI YWLAQCLYLT
60 70 80 90 100
AQYHRASHAL RSRKLDKLYG ACQYLAARCH YAAKEYQQAL DILDMEEAAS
110 120 130 140 150
KKLLDKNLKE ENGSREIVKD WEMSPASINS SICLLRGKIY DAMDNRPLAT
160 170 180 190 200
SSYKEALKLD VYCFEAFDLL TSHHMLTAQE EKDFLDSLPL SQQCTEEEVE
210 220 230 240 250
LLHFLFENKL KKYNKPSEMV VPDIVNGLQD NLDVVVSLAE RHYYNCDFKM
260 270 280 290 300
CYSLTSMVMV KDPFHANCLP VHIGTLVELS KANELFYLSH KLVDLYPSNP
310 320 330 340 350
VSWFAVGCYY LMVGHKNEHA RRYLSKATTL ERTYGPAWIA YGHSFAVESE
360 370 380 390 400
HDQAMAAYFT AAQLMKGCHL PMLYIGLEYG LTNNPKLAEH FFSQALSIAP
410 420 430 440 450
EDPFVIHEVA VVAFQNGDYK TSEKLFLDAM EKIKAIGNEV TVDKWEPLLN
460 470 480 490 500
NLGHVCRKLK KYEQALEYHR QALVLIPQNA STYSAIGYVH SLKGDFESAI
510 520 530 540 550
DYFHTALGLK RDDTFSVTML GHCIEMYISD SDAYIGTDIK DKVRKTLNTP
560 570 580 590 600
ALMKMLNTSA DGNESRAQPV EEVNVCIETP SFNADKQTDA FQRFLLECDM
610
HESDMMLETS MSDTST
Length:616
Mass (Da):70,468
Last modified:April 8, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2218E94B44A45EE9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8QH62A0A2R8QH62_DANRE
Cell division cycle 16 homolog (S. ...
cdc16
600Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0V222B0V222_DANRE
Cell division cycle 16 homolog (S. ...
cdc16
162Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX601644 Genomic DNA No translation available.
CR936415 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000077814; ENSDARP00000072280; ENSDARG00000055470

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX601644 Genomic DNA No translation available.
CR936415 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000072280

Proteomic databases

PaxDbiB0S729
PeptideAtlasiB0S729

Genome annotation databases

EnsembliENSDART00000077814; ENSDARP00000072280; ENSDARG00000055470

Organism-specific databases

ZFINiZDB-GENE-051113-132 cdc16

Phylogenomic databases

eggNOGiKOG1173 Eukaryota
ENOG410XNY1 LUCA
GeneTreeiENSGT00950000182950
HOGENOMiCLU_011751_3_2_1
InParanoidiB0S729
OMAiQFIDMRR
TreeFamiTF101054

Enzyme and pathway databases

ReactomeiR-DRE-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
R-DRE-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-DRE-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DRE-174154 APC/C:Cdc20 mediated degradation of Securin
R-DRE-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DRE-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DRE-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-DRE-176408 Regulation of APC/C activators between G1/S and early anaphase
R-DRE-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
R-DRE-176412 Phosphorylation of the APC/C
R-DRE-179409 APC-Cdc20 mediated degradation of Nek2A
R-DRE-2467813 Separation of Sister Chromatids
R-DRE-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-DRE-69017 CDK-mediated phosphorylation and removal of Cdc6
R-DRE-983168 Antigen processing: Ubiquitination & Proteasome degradation

Gene expression databases

BgeeiENSDARG00000055470 Expressed in multi-cellular organism and 20 other tissues
ExpressionAtlasiB0S729 baseline

Family and domain databases

InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
SMARTiView protein in SMART
SM00028 TPR, 5 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 5 hits
PS50293 TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB0S729_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B0S729
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: February 26, 2020
This is version 83 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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