Novel protein similar to vertebrate furin (Paired basic amino acid cleaving enzyme) (FURIN)

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• serine-type endopeptidase activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cartilage development Source: ZFIN <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Zebrafish furin mutants reveal intricacies in regulating Endothelin1 signaling in craniofacial patterning."
    Walker M.B., Miller C.T., Coffin Talbot J., Stock D.W., Kimmel C.B.
    Dev Biol 295:194-205(2006) [PubMed] [Europe PMC] [Abstract]
• cartilage morphogenesis Source: ZFINInferred from mutant phenotypeⁱ
  • "Jaw and branchial arch mutants in zebrafish II: anterior arches and cartilage differentiation."
    Piotrowski T., Schilling T.F., Brand M., Jiang Y.J., Heisenberg C.P., Beuchle D., Grandel H., van Eeden F.J., Furutani-Seiki M., Granato M., Haffter P., Hammerschmidt M., Kane D.A., Kelsh R.N., Mullins M.C., Odenthal J., Warga R.M., Nusslein-Volhard C.
    Development 123:345-356(1996) [PubMed] [Europe PMC] [Abstract]
• determination of digestive tract left/right asymmetry Source: ZFINInferred from mutant phenotypeⁱ
  • "Nodal signaling range is regulated by proprotein convertase-mediated maturation."
    Tessadori F., Noel E.S., Rens E.G., Magliozzi R., Evers-van Gogh I.J., Guardavaccaro D., Merks R.M., Bakkers J.
    Dev Cell 32:631-639(2015) [PubMed] [Europe PMC] [Abstract]
• determination of heart left/right asymmetry Source: ZFINInferred from mutant phenotypeⁱ
  • "Nodal signaling range is regulated by proprotein convertase-mediated maturation."
    Tessadori F., Noel E.S., Rens E.G., Magliozzi R., Evers-van Gogh I.J., Guardavaccaro D., Merks R.M., Bakkers J.
    Dev Cell 32:631-639(2015) [PubMed] [Europe PMC] [Abstract]
• determination of left/right asymmetry in lateral mesoderm Source: ZFINInferred from mutant phenotypeⁱ
  • "Nodal signaling range is regulated by proprotein convertase-mediated maturation."
    Tessadori F., Noel E.S., Rens E.G., Magliozzi R., Evers-van Gogh I.J., Guardavaccaro D., Merks R.M., Bakkers J.
    Dev Cell 32:631-639(2015) [PubMed] [Europe PMC] [Abstract]
• embryonic viscerocranium morphogenesis Source: ZFINInferred from mutant phenotypeⁱ
  • "Alcama mediates Edn1 signaling during zebrafish cartilage morphogenesis."
    Choudhry P., Joshi D., Funke B., Trede N.
    Dev Biol 349:483-493(2011) [PubMed] [Europe PMC] [Abstract]
• fin morphogenesis Source: ZFINInferred from mutant phenotypeⁱ
  • "Genetic analysis of fin development in zebrafish identifies furin and hemicentin1 as potential novel fraser syndrome disease genes."
    Carney T.J., Feitosa N.M., Sonntag C., Slanchev K., Kluger J., Kiyozumi D., Gebauer J.M., Coffin Talbot J., Kimmel C.B., Sekiguchi K., Wagener R., Schwarz H., Ingham P.W., Hammerschmidt M.
    PLoS Genet 6:e1000907-e1000907(2010) [PubMed] [Europe PMC] [Abstract]
• heart jogging Source: ZFINInferred from mutant phenotypeⁱ
  • "Nodal signaling range is regulated by proprotein convertase-mediated maturation."
    Tessadori F., Noel E.S., Rens E.G., Magliozzi R., Evers-van Gogh I.J., Guardavaccaro D., Merks R.M., Bakkers J.
    Dev Cell 32:631-639(2015) [PubMed] [Europe PMC] [Abstract]
• heart looping Source: ZFINInferred from mutant phenotypeⁱ
  • "Dominant-negative ALK2 allele associates with congenital heart defects."
    Smith K.A., Joziasse I.C., Chocron S., van Dinther M., Guryev V., Verhoeven M.C., Rehmann H., van der Smagt J.J., Doevendans P.A., Cuppen E., Mulder B.J., Ten Dijke P., Bakkers J.
    Circulation 119:3062-3069(2009) [PubMed] [Europe PMC] [Abstract]
  • "Nodal signaling range is regulated by proprotein convertase-mediated maturation."
    Tessadori F., Noel E.S., Rens E.G., Magliozzi R., Evers-van Gogh I.J., Guardavaccaro D., Merks R.M., Bakkers J.
    Dev Cell 32:631-639(2015) [PubMed] [Europe PMC] [Abstract]
• peptide hormone processing Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein processing Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• response to bacterium Source: ZFINInferred from mutant phenotypeⁱ
  • "The proprotein convertase subtilisin/kexin furinA regulates zebrafish host response against Mycobacterium marinum."
    Ojanen M.J., Turpeinen H., Cordova Z.M., Hammaren M.M., Harjula S.K., Parikka M., Ramet M., Pesu M.
    Infect Immun 83:1431-1442(2015) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Keywords - PTMⁱ

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Fragment.

        10         20         30         40         50
MDLRLASLTL GTLLVLLTSG PQPSIGQKVY TNTWAVHIEG GEEEADRIAR 
        60         70         80         90        100
KHSFVNHGNV FGDYYHFRHR TVVKRSLSEH RGTHIRLHTE PQVMWAEQQV 
       110        120        130        140        150
VKRRKKRDVY YEPTDPKFAQ QWYLYNQDHL DLNVKNAWKQ GVTGQGVVVS 
       160        170        180        190        200
ILDDGIEKNH PDLVQNYDPD ASYDVNDGDP DPQPRYTQLN DNRHGTRCAG 
       210        220        230        240        250
EVAAVADNDI CGVGVAYNAR IGGVRMLDGE VTDVVEAQSL SLNPQHIDIY 
       260        270        280        290        300
SASWGPEDDG KTVDGPAKLA KEAFQRGVIE GRGGRGSIFV WASGNGGRMK 
       310        320        330        340        350
DSCNCDGYTN SIYTLSISSS TQNGNVPWYS EACSSTLAST YSSGGVNEKQ 
       360        370        380        390        400
IVTTDLRQKC TDSHTGTSAS APLAAGIIAL ALEANKNLTW RDMQHLVVRT 
       410        420        430        440        450
SNPAHLTTND WKINGVGRRV SHSYGYGLLD AGAIVALAKN WTNVGPQHKC 
       460        470        480        490        500
VLSLVSEPRN IGSYLVINKT VDACTGMANF VSSLEHVQAQ LTLSYNRRGN 
       510        520        530        540        550
LAIYLISPQG TRSTLLPPRP HDYSSEGFND WAFMTTHSWD EDPRGEWTLE 
       560
IKNVAGTSDY                                             

Experimental Info

Sequence databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein family/group databases

Organism-specific databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ