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Entry version 112 (07 Oct 2020)
Sequence version 1 (08 Apr 2008)
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Protein
Submitted name:

Tenascin N

Gene

tnn

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • integrin binding Source: GO_Central

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Tenascin NImported
Submitted name:
Tenascin WImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tnnImported
Synonyms:tnwImported
ORF Names:DKEY-4I23.1-002Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-990415-262, tnn

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Extracellular matrixARBA annotation, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501508700728 – 844Sequence analysisAdd BLAST817

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi163 ↔ 173PROSITE-ProRule annotation
Disulfide bondi180 ↔ 189PROSITE-ProRule annotation
Disulfide bondi225 ↔ 235PROSITE-ProRule annotation
Disulfide bondi242 ↔ 251PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000024829, Expressed in embryo and 26 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini159 – 190EGF-likeInterPro annotationAdd BLAST32
Domaini221 – 252EGF-likeInterPro annotationAdd BLAST32
Domaini256 – 344Fibronectin type-IIIInterPro annotationAdd BLAST89
Domaini345 – 435Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini436 – 523Fibronectin type-IIIInterPro annotationAdd BLAST88
Domaini524 – 614Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini612 – 828Fibrinogen C-terminalInterPro annotationAdd BLAST217

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tenascin family.ARBA annotation

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, SignalSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000166882

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063, FN3, 4 hits
cd00087, FReD, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000742, EGF-like_dom
IPR041161, EGF_Tenascin
IPR036056, Fibrinogen-like_C
IPR002181, Fibrinogen_a/b/g_C_dom
IPR020837, Fibrinogen_CS
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18720, EGF_Tenascin, 3 hits
PF00147, Fibrinogen_C, 1 hit
PF00041, fn3, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 4 hits
SM00186, FBG, 1 hit
SM00060, FN3, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265, SSF49265, 2 hits
SSF56496, SSF56496, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022, EGF_1, 2 hits
PS01186, EGF_2, 2 hits
PS50026, EGF_3, 2 hits
PS00514, FIBRINOGEN_C_1, 1 hit
PS51406, FIBRINOGEN_C_2, 1 hit
PS50853, FN3, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

B0S6K6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVRLNRLKR GLFLLGTLFM VSHIVLSEEA VNAEKEVTFS HVYRIDSSCK
60 70 80 90 100
QGSQVGQLSQ DQASEGQLVT VNGENDIVFK HSIRLQPAGC GCADSEDFKA
110 120 130 140 150
LLYRVNGLEE EVNYLKSQCA QGCCKGGAGV DTSCSGHGTY QQDSCSCKCN
160 170 180 190 200
PGWEGPDCSI SSCPDECNDN GRCVDGRCVC YEGYTGHDCS QLTCPNDCKD
210 220 230 240 250
KGHCVDGKCV CFSGFSGEDC SIATCPNDCI GNGRCVDGQC ICDEGFFGID
260 270 280 290 300
CSMVLGPKGL RLIKVTDVSL LVEWESVRGA EYYILSYHPK GNKGAIKEVQ
310 320 330 340 350
VENTKNSYLI TGLKPGVTYI VQVYAVIRGI NSESDQITAT TEVSGIEGIK
360 370 380 390 400
VLSQTEDSIQ VDWKNPGIIV DYFKLTHASH DGQGGHENVV MSQEARTKHT
410 420 430 440 450
IVGLNPGTEY QIGVQAIKGE NEGKASFATG VTDIDAPTNL ATREVTENSA
460 470 480 490 500
TVTWDGVRAE IDGYMLTYSS AEGTSREIKV AAGATSYQLT SLKPGVLYTV
510 520 530 540 550
FLWAYKGSRS SRKSMTEAET EIDAPKNLKA TDVQTQTSTL TWKAPQANIE
560 570 580 590 600
GYILTYRAED GSMQTVEKTL TARENRFALS GLEMGKKYIV TLIAYRGSKR
610 620 630 640 650
SKIVETTFST VGLAYQFPMD CTQIMRNGNM ESGVYTIYVN NNRSRTMQVY
660 670 680 690 700
CDMKTDGGGW IVFQRRNTGK VDFMKKWRDY MKGFGELTEE FWLGLDKIHE
710 720 730 740 750
LTNTPTQYEA RFDLGSGSDR KYAVYDNFKV APSKQKFKLT IGSYKGNAGD
760 770 780 790 800
AMTYHQGAPF STVDSDNDIA LGNCALTHQG AWWYKNCHLA NLNGRFGDNR
810 820 830 840
HSMGVNWEPW KGHLQSLDFA EIKIRPVGAA GRQKRSLKRR VAAY
Length:844
Mass (Da):92,870
Last modified:April 8, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4119D4EFD930F73B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0S6K5B0S6K5_DANRE
Tenascin N
tnn tnw, DKEY-4I23.1-001
932Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1QSR3F1QSR3_DANRE
Tenascin N
tnn tnw
1,020Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FP236741 Genomic DNA No translation available.
BX537326 Genomic DNA Translation: CAQ14535.1

NCBI Reference Sequences

More...
RefSeqi
XP_005171322.1, XM_005171265.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000029006; ENSDARP00000033045; ENSDARG00000024829

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
30234

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP236741 Genomic DNA No translation available.
BX537326 Genomic DNA Translation: CAQ14535.1
RefSeqiXP_005171322.1, XM_005171265.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSDART00000029006; ENSDARP00000033045; ENSDARG00000024829
GeneIDi30234

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
63923
ZFINiZDB-GENE-990415-262, tnn

Phylogenomic databases

GeneTreeiENSGT00940000166882

Gene expression databases

BgeeiENSDARG00000024829, Expressed in embryo and 26 other tissues

Family and domain databases

CDDicd00063, FN3, 4 hits
cd00087, FReD, 1 hit
Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR000742, EGF-like_dom
IPR041161, EGF_Tenascin
IPR036056, Fibrinogen-like_C
IPR002181, Fibrinogen_a/b/g_C_dom
IPR020837, Fibrinogen_CS
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
PfamiView protein in Pfam
PF18720, EGF_Tenascin, 3 hits
PF00147, Fibrinogen_C, 1 hit
PF00041, fn3, 4 hits
SMARTiView protein in SMART
SM00181, EGF, 4 hits
SM00186, FBG, 1 hit
SM00060, FN3, 4 hits
SUPFAMiSSF49265, SSF49265, 2 hits
SSF56496, SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00022, EGF_1, 2 hits
PS01186, EGF_2, 2 hits
PS50026, EGF_3, 2 hits
PS00514, FIBRINOGEN_C_1, 1 hit
PS51406, FIBRINOGEN_C_2, 1 hit
PS50853, FN3, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB0S6K6_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B0S6K6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: October 7, 2020
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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