UniProtKB - B0S6E3 (B0S6E3_DANRE)
Protein
Receptor protein serine/threonine kinase
Gene
tgfbr1a
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Catalytic activityi
- EC:2.7.11.30ARBA annotation
- ATP + L-threonyl-[receptor-protein] = ADP + H+ + O-phospho-L-threonyl-[receptor-protein]ARBA annotationEC:2.7.11.30ARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 229 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- activin binding Source: GO_Central
- activin receptor activity, type I Source: GO_Central
- ATP binding Source: UniProtKB-UniRule
- protein serine/threonine kinase activity Source: GO_Central
- SMAD binding Source: GO_Central
- transforming growth factor beta receptor activity, type I Source: GO_Central
GO - Biological processi
- activin receptor signaling pathway Source: GO_Central
- cellular response to growth factor stimulus Source: GO_Central
- heart development Source: GO_Central
- nervous system development Source: GO_Central
- protein phosphorylation Source: GO_Central
- transforming growth factor beta receptor signaling pathway Source: GO_Central
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseUniRule annotationARBA annotation, Transferase |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Receptor protein serine/threonine kinaseARBA annotation (EC:2.7.11.30ARBA annotation) |
Gene namesi | Name:tgfbr1aImported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-051120-75, tgfbr1a |
Subcellular locationi
Plasma Membrane
- activin receptor complex Source: GO_Central
- plasma membrane Source: GO_Central
Other locations
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 121 – 144 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | Sequence analysisAdd BLAST | 31 | |
ChainiPRO_5002754800 | 32 – 500 | Receptor protein serine/threonine kinaseSequence analysisAdd BLAST | 469 |
Proteomic databases
PaxDbi | B0S6E3 |
PeptideAtlasi | B0S6E3 |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000017494, Expressed in liver and 27 other tissues |
Interactioni
GO - Molecular functioni
- SMAD binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000111880 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 172 – 201 | GSInterPro annotationAdd BLAST | 30 | |
Domaini | 202 – 492 | Protein kinaseInterPro annotationAdd BLAST | 291 |
Sequence similaritiesi
Belongs to the protein kinase superfamily.UniRule annotation
Keywords - Domaini
SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | KOG2052, Eukaryota |
GeneTreei | ENSGT00940000156394 |
HOGENOMi | CLU_000288_8_1_1 |
InParanoidi | B0S6E3 |
OMAi | THIRECI |
TreeFami | TF314724 |
Family and domain databases
InterProi | View protein in InterPro IPR000472, Activin_recp IPR003605, GS_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR000333, TGFB_receptor |
PANTHERi | PTHR23255, PTHR23255, 1 hit |
Pfami | View protein in Pfam PF01064, Activin_recp, 1 hit PF00069, Pkinase, 1 hit PF08515, TGF_beta_GS, 1 hit |
SMARTi | View protein in SMART SM00467, GS, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51256, GS, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
B0S6E3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSAAMDVAS LTSRSLLLAL LVLSVTHEAQ GLLCYCERCV NRSCNTTGLC
60 70 80 90 100
FAVIAKSSGQ TVTQEHQCIQ QDDLYPRDRP FQCAPSNNGK HPYCCNTHMC
110 120 130 140 150
NKNPKVIPEL PEAEPQSMSP IALAAMIAVP ICVLSFVLVL LFYMCHNRSI
160 170 180 190 200
IHHRVPSEED PTMDHPFLAD GTTLKDLIYD MTTSGSGSGL PLLVQRTIAR
210 220 230 240 250
TIILQESIGK GRFGEVWRGR WRGEEVAVKI FSSREERSWF REAEIYQTVM
260 270 280 290 300
LRHENILGFI AADNKDNGTW TQLWLVSDYH EHGSLFDYLN RYTVTVEGMI
310 320 330 340 350
KLSLSTASGL AHLHMEIVGT QGKPAIAHRD LKSKNILVKK NGTCCIADLG
360 370 380 390 400
LAVRHDSATD TIDIAPNHRV GTKRYMAPEV LDDSINMRHF ESFKRADIYA
410 420 430 440 450
LGLVFWEIAR RCSIGGIHED YQLPYYDLVP SDPSVEDMKR VVCDQKLRPN
460 470 480 490 500
IPNRWQSCEA LRVMAKIMRE CWYANGGARL TALRVKKSLS QLSQQEGIKI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX511097 Genomic DNA No translation available. BX649335 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSDART00000121885; ENSDARP00000111880; ENSDARG00000017494 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX511097 Genomic DNA No translation available. BX649335 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000111880 |
Proteomic databases
PaxDbi | B0S6E3 |
PeptideAtlasi | B0S6E3 |
Genome annotation databases
Ensembli | ENSDART00000121885; ENSDARP00000111880; ENSDARG00000017494 |
Organism-specific databases
ZFINi | ZDB-GENE-051120-75, tgfbr1a |
Phylogenomic databases
eggNOGi | KOG2052, Eukaryota |
GeneTreei | ENSGT00940000156394 |
HOGENOMi | CLU_000288_8_1_1 |
InParanoidi | B0S6E3 |
OMAi | THIRECI |
TreeFami | TF314724 |
Gene expression databases
Bgeei | ENSDARG00000017494, Expressed in liver and 27 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR000472, Activin_recp IPR003605, GS_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR000333, TGFB_receptor |
PANTHERi | PTHR23255, PTHR23255, 1 hit |
Pfami | View protein in Pfam PF01064, Activin_recp, 1 hit PF00069, Pkinase, 1 hit PF08515, TGF_beta_GS, 1 hit |
SMARTi | View protein in SMART SM00467, GS, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51256, GS, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B0S6E3_DANRE | |
Accessioni | B0S6E3Primary (citable) accession number: B0S6E3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 8, 2008 |
Last sequence update: | April 8, 2008 | |
Last modified: | April 7, 2021 | |
This is version 97 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |