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Entry version 88 (13 Feb 2019)
Sequence version 1 (08 Apr 2008)
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Protein
Submitted name:

Fibronectin 1a

Gene

fn1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • integrin binding Source: ZFIN

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-114608 Platelet degranulation
R-DRE-1474228 Degradation of the extracellular matrix
R-DRE-1474244 Extracellular matrix organization
R-DRE-1566977 Fibronectin matrix formation
R-DRE-202733 Cell surface interactions at the vascular wall
R-DRE-2129379 Molecules associated with elastic fibres
R-DRE-216083 Integrin cell surface interactions
R-DRE-3000171 Non-integrin membrane-ECM interactions
R-DRE-3000178 ECM proteoglycans
R-DRE-354192 Integrin alphaIIb beta3 signaling
R-DRE-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-DRE-372708 p130Cas linkage to MAPK signaling for integrins
R-DRE-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-DRE-5674135 MAP2K and MAPK activation
R-DRE-8874081 MET activates PTK2 signaling
R-DRE-8957275 Post-translational protein phosphorylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Fibronectin 1aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fn1aImported
Synonyms:fn1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-000426-1 fn1a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500275477722 – 2480Sequence analysisAdd BLAST2459

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi356 ↔ 382PROSITE-ProRule annotation
Disulfide bondi370 ↔ 397PROSITE-ProRule annotation
Disulfide bondi416 ↔ 442PROSITE-ProRule annotation
Disulfide bondi430 ↔ 457PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B0S602

PeptideAtlas

More...
PeptideAtlasi
B0S602

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000019815 Expressed in 46 organ(s), highest expression level in pharyngeal gill

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
B0S602 baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000112231

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
B0S602

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini44 – 83Fibronectin type-IInterPro annotationAdd BLAST40
Domaini88 – 131Fibronectin type-IInterPro annotationAdd BLAST44
Domaini132 – 175Fibronectin type-IInterPro annotationAdd BLAST44
Domaini177 – 221Fibronectin type-IInterPro annotationAdd BLAST45
Domaini222 – 266Fibronectin type-IInterPro annotationAdd BLAST45
Domaini301 – 340Fibronectin type-IInterPro annotationAdd BLAST40
Domaini351 – 399Fibronectin type-IIInterPro annotationAdd BLAST49
Domaini411 – 459Fibronectin type-IIInterPro annotationAdd BLAST49
Domaini464 – 508Fibronectin type-IInterPro annotationAdd BLAST45
Domaini513 – 555Fibronectin type-IInterPro annotationAdd BLAST43
Domaini556 – 599Fibronectin type-IInterPro annotationAdd BLAST44
Domaini607 – 706Fibronectin type-IIIInterPro annotationAdd BLAST100
Domaini711 – 808Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini809 – 900Fibronectin type-IIIInterPro annotationAdd BLAST92
Domaini907 – 998Fibronectin type-IIIInterPro annotationAdd BLAST92
Domaini999 – 1087Fibronectin type-IIIInterPro annotationAdd BLAST89
Domaini1088 – 1174Fibronectin type-IIIInterPro annotationAdd BLAST87
Domaini1175 – 1266Fibronectin type-IIIInterPro annotationAdd BLAST92
Domaini1268 – 1358Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini1359 – 1453Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini1454 – 1541Fibronectin type-IIIInterPro annotationAdd BLAST88
Domaini1542 – 1635Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini1636 – 1726Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini1727 – 1815Fibronectin type-IIIInterPro annotationAdd BLAST89
Domaini1816 – 1909Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini1910 – 1998Fibronectin type-IIIInterPro annotationAdd BLAST89
Domaini2001 – 2097Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini2195 – 2288Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini2297 – 2341Fibronectin type-IInterPro annotationAdd BLAST45
Domaini2342 – 2384Fibronectin type-IInterPro annotationAdd BLAST43
Domaini2386 – 2426Fibronectin type-IInterPro annotationAdd BLAST41

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IF4N Eukaryota
ENOG410Y2NH LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155126

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234344

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG005731

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B0S602

KEGG Orthology (KO)

More...
KOi
K05717

Identification of Orthologs from Complete Genome Data

More...
OMAi
YILRWKP

Database of Orthologous Groups

More...
OrthoDBi
6580at2759

TreeFam database of animal gene trees

More...
TreeFami
TF329915

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00061 FN1, 10 hits
cd00062 FN2, 2 hits
cd00063 FN3, 16 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.10.10, 2 hits
2.60.40.10, 17 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000083 Fibronectin_type1
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR013783 Ig-like_fold
IPR013806 Kringle-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00039 fn1, 11 hits
PF00040 fn2, 2 hits
PF00041 fn3, 16 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00058 FN1, 12 hits
SM00059 FN2, 2 hits
SM00060 FN3, 17 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 10 hits
SSF57440 SSF57440, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01253 FN1_1, 4 hits
PS51091 FN1_2, 12 hits
PS00023 FN2_1, 1 hit
PS51092 FN2_2, 2 hits
PS50853 FN3, 17 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

B0S602-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFGGPLGTAL AVALLACAVQ CMPKGTGKHK RQAQEHSVSS VSQDGCVMDG
60 70 80 90 100
QFYGAGEKWE RIYLGSTLLC TCHGVSKIEC KSKPDAEETC YDKVNSRSYR
110 120 130 140 150
VGETYERPKD GMIWDCTCIG SARGKISCTI ANRCHEGGHS YKIGDTWQRP
160 170 180 190 200
HDTGDYMLEC VCLGNGKGEW TCKPVAERCY DNTAGTSYMV GETWEKPYQG
210 220 230 240 250
WMIVDCTCLG EGSGRITCTS RNRCNDQDTR TSYRIGDTWS KTDSRGHVLQ
260 270 280 290 300
CLCTGNGRGE WKCERHASLH TTSLGTGSRV VTNVQPAVYH PQGVPEHPVE
310 320 330 340 350
GSCLTEAGVS YAPGMRWSKA QGSKQMLCTC LGNGVSCEES ESQSQVYGGT
360 370 380 390 400
SGGEPCAFPF VFMGKTFYSC TSEGRNDGQL WCSTSSDFEK DYKYSFCTSN
410 420 430 440 450
NVVVTTRGGN SNGALCQFPF LYNGRNYTDC TADGRRDGMK WCGTTYNFDK
460 470 480 490 500
EQRFGFCPMA AHEEVCTTNE GVMYRVGDQW DRRHDVLGHM MRCTCVGNGR
510 520 530 540 550
GEWSCIAYSQ LKDQCIVDNL TYEVNQTFTK RHDEGYTMNC TCFGQGRGRW
560 570 580 590 600
KCDAIDQCQE PETRVFYQIG ESWDKLIQGI HYRCYCYGNG IGELSCEPQH
610 620 630 640 650
SISGGHRPVQ VIISEAGNQP NSHPIQWNAP ASAHITQYIL KWRPKNTHIQ
660 670 680 690 700
WMEVTIPGHV NSYTIAGLKP GVTYEGQLIS ILRFGRRETT RFDFSTVHGS
710 720 730 740 750
LETSEGETTQ PPRMVDTSES VTEITSSSFV ISWVSASDTV SGFRVEYELS
760 770 780 790 800
EEGGQTGQPM ILDLPHSATS VNISELLPGR KYTVNVYEVT GEGEPNLILT
810 820 830 840 850
TSQTTAPDAP SDHEVEDVAD TSIRISWSKP LAPITGYRVV YTPSEEGSSG
860 870 880 890 900
SVELNLPEHS TSLTLGDLRP GVLYNISIFS VEENQESEPV FVQVTTAGEP
910 920 930 940 950
LAEEVPSPTD LQFYEVSDSK ITITWTSPSS EVSGYRVSVG EVGPDGLIEK
960 970 980 990 1000
EVPYPVTQNA YAEITHLQPG TLYRFFIFSL KSGEESEPLV GEQATKPDPP
1010 1020 1030 1040 1050
TDIYFSNITE DSAVIVWLPP TAQITGYRLF LTVEGSNPKQ LRIPGRLSQY
1060 1070 1080 1090 1100
TLLNLQPDTE YSATLHAERG NVLSEGSIAT FATTPPMGNA PYFSTDVTDT
1110 1120 1130 1140 1150
SIIVSWSPLP KIGYKLTVRP SQGGEAPRDV TSELGSVLIS GLTPGVEYTY
1160 1170 1180 1190 1200
SVQPVISGQE HGNPITRRVV TPLSPPTDLN LESNPNTGKL TVQWNDANIP
1210 1220 1230 1240 1250
DITGYRVTCT PTKGQQGNSL EEFVKAGQNS CTLENLSPGV EYNVSVFTVK
1260 1270 1280 1290 1300
DDMESVPVFT TVTPDVPKIT DLSFINVTDS TIGLSWSPLN STAVTGYRIT
1310 1320 1330 1340 1350
VLAAGDSVPI FVEFVEPTTG FYTVHGLEPG IDYDITVTTV TENGESEPIT
1360 1370 1380 1390 1400
ITQQTAVPAP YGLSFGEVTA DTMLVTWKAP QVPKSSDINQ YIIRYHPVDE
1410 1420 1430 1440 1450
DDETTERTVE GSENFVVLRH LVPNTEYLVS VICVYEGREG SPAIGTQRTV
1460 1470 1480 1490 1500
FDAPVGLQFS DVGTTSFTVR WQAPRAIISG YRIRYQMTSG GRAKEERLPP
1510 1520 1530 1540 1550
SRSHFTLTGL TPETEYSISV YAVSGSRDSL PLTGTQSTIS DAPTDLEVIS
1560 1570 1580 1590 1600
STPTSITVRW DAPSVTVRYY RITHGESGGS DAPLEFMVPG SQSTATIEDL
1610 1620 1630 1640 1650
RPGTDYTITV YAVTGRGDSP ASSTPIHVKH RTDIDSPSQM EVTDVKDNTI
1660 1670 1680 1690 1700
TVRWTPAAGP ISRYRVNATP LTGEGPVLHA ETTSDHTEIT FSGLMPAVEY
1710 1720 1730 1740 1750
SIKVYALGQD GESLPLVENV VTTVDKPKDL SFTDVESSSM RISWDSPDGV
1760 1770 1780 1790 1800
VSSYRVLYYS PEEGERELFP APHGDDESAV LHGLRPGTEY TVKVIALHDQ
1810 1820 1830 1840 1850
SPSTALVGTQ TTGIPGPTRL QFSQVGPTSF TVSWSSSDAS LTGYRVAVSP
1860 1870 1880 1890 1900
KSKSGPTKEE NITPDSTEFH ATGLMPGTDY EVEVYGVKNS LTSPRVKGEI
1910 1920 1930 1940 1950
TTPDNISPPR RVRISNVKDS SITLTWRSKT EAISGFLVEA TPTMGGHNPI
1960 1970 1980 1990 2000
QRTIEPDSRT YTIAGLEPGT NYKINIYTLN GNSRSEPFTL TATTAKPVIS
2010 2020 2030 2040 2050
PPTNLHFTSL ASTSISFTWE PPRSTITGYY VTYEEAGGIP KELTPRPQAA
2060 2070 2080 2090 2100
RTFASISGLI PGTEYIIKIV ALNGAQRSTP LIGKARTQLE IEQLPPQLPN
2110 2120 2130 2140 2150
PSRPHLEVLD VPEDNDNFNN HVHVLGPNRH NTLGQQGQHI YTEYQSFNLG
2160 2170 2180 2190 2200
NNGQQPHHPN HGEPLVYIPL PGADGQRVPV VKVNEGQEAG FPFGGLFNET
2210 2220 2230 2240 2250
NLPQESQTQT TIVWQPVPHT SEYVVWCDPI TEINEKSFQM RLPGTSTSAT
2260 2270 2280 2290 2300
LIGLTSGASY NVLVESVNGD QKQKVLQDVV TVGNSVPGAG VIPTGRDVCY
2310 2320 2330 2340 2350
DSFTATYHEV NTEWERMSET GFKLWCKCLG LGSGHFRCDS SKWCHDSGHN
2360 2370 2380 2390 2400
YRIGEKWDRR AENGHMMSCT CLGNGKGEFK CEPHESTCYD EGKLYQVGNQ
2410 2420 2430 2440 2450
WQKEYLGAIC TCTCYGGQQG WRCENCRRPG AEVDADLIQP PVRTDAFDRY
2460 2470 2480
RENALRKLNI QCPIECLRPD LLADAHSPHD
Length:2,480
Mass (Da):271,960
Last modified:April 8, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE2C29D4C0DC149EB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1RBP8F1RBP8_DANRE
Fibronectin 1a
fn1a fn1
2,480Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Q0R2A0A2R8Q0R2_DANRE
Fibronectin 1a
fn1a
44Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX323049 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_571595.2, NM_131520.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Dr.51894

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000124346; ENSDARP00000112231; ENSDARG00000019815

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100005469

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:100005469

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX323049 Genomic DNA No translation available.
RefSeqiNP_571595.2, NM_131520.2
UniGeneiDr.51894

3D structure databases

ProteinModelPortaliB0S602
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000112231

Proteomic databases

PaxDbiB0S602
PeptideAtlasiB0S602

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000124346; ENSDARP00000112231; ENSDARG00000019815
GeneIDi100005469
KEGGidre:100005469

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100005469
ZFINiZDB-GENE-000426-1 fn1a

Phylogenomic databases

eggNOGiENOG410IF4N Eukaryota
ENOG410Y2NH LUCA
GeneTreeiENSGT00940000155126
HOGENOMiHOG000234344
HOVERGENiHBG005731
InParanoidiB0S602
KOiK05717
OMAiYILRWKP
OrthoDBi6580at2759
TreeFamiTF329915

Enzyme and pathway databases

ReactomeiR-DRE-114608 Platelet degranulation
R-DRE-1474228 Degradation of the extracellular matrix
R-DRE-1474244 Extracellular matrix organization
R-DRE-1566977 Fibronectin matrix formation
R-DRE-202733 Cell surface interactions at the vascular wall
R-DRE-2129379 Molecules associated with elastic fibres
R-DRE-216083 Integrin cell surface interactions
R-DRE-3000171 Non-integrin membrane-ECM interactions
R-DRE-3000178 ECM proteoglycans
R-DRE-354192 Integrin alphaIIb beta3 signaling
R-DRE-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-DRE-372708 p130Cas linkage to MAPK signaling for integrins
R-DRE-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-DRE-5674135 MAP2K and MAPK activation
R-DRE-8874081 MET activates PTK2 signaling
R-DRE-8957275 Post-translational protein phosphorylation

Gene expression databases

BgeeiENSDARG00000019815 Expressed in 46 organ(s), highest expression level in pharyngeal gill
ExpressionAtlasiB0S602 baseline

Family and domain databases

CDDicd00061 FN1, 10 hits
cd00062 FN2, 2 hits
cd00063 FN3, 16 hits
Gene3Di2.10.10.10, 2 hits
2.60.40.10, 17 hits
InterProiView protein in InterPro
IPR000083 Fibronectin_type1
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR013783 Ig-like_fold
IPR013806 Kringle-like
PfamiView protein in Pfam
PF00039 fn1, 11 hits
PF00040 fn2, 2 hits
PF00041 fn3, 16 hits
SMARTiView protein in SMART
SM00058 FN1, 12 hits
SM00059 FN2, 2 hits
SM00060 FN3, 17 hits
SUPFAMiSSF49265 SSF49265, 10 hits
SSF57440 SSF57440, 2 hits
PROSITEiView protein in PROSITE
PS01253 FN1_1, 4 hits
PS51091 FN1_2, 12 hits
PS00023 FN2_1, 1 hit
PS51092 FN2_2, 2 hits
PS50853 FN3, 17 hits

ProtoNet; Automatic hierarchical classification of proteins

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB0S602_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B0S602
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: February 13, 2019
This is version 88 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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