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Protein

Acetate kinase

Gene

ackA

Organism
Clavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1) (Corynebacterium sepedonicum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. Phosphate acetyltransferase (CMS0153)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8MagnesiumUniRule annotation1
Binding sitei15ATPUniRule annotation1
Binding sitei89SubstrateUniRule annotation1
Active sitei146Proton donor/acceptorUniRule annotation1
Sitei178Transition state stabilizerUniRule annotation1
Sitei239Transition state stabilizerUniRule annotation1
Metal bindingi382MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi206 – 210ATPUniRule annotation5
Nucleotide bindingi280 – 282ATPUniRule annotation3
Nucleotide bindingi328 – 332ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00340; UER00458

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:CMS0154
OrganismiClavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1) (Corynebacterium sepedonicum)
Taxonomic identifieri31964 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrobacteriaceaeClavibacter
Proteomesi
  • UP000001318 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000741821 – 396Acetate kinaseAdd BLAST396

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi31964.CMS_0154

Structurei

3D structure databases

ProteinModelPortaliB0RIG4
SMRiB0RIG4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6H Bacteria
COG0282 LUCA
KOiK00925
OMAiWKALTGT
OrthoDBiPOG091H02K4

Family and domain databases

HAMAPiMF_00020 Acetate_kinase, 1 hit
InterProiView protein in InterPro
IPR004372 Ac/propionate_kinase
IPR000890 Aliphatic_acid_kin_short-chain
IPR023865 Aliphatic_acid_kinase_CS
PANTHERiPTHR21060 PTHR21060, 1 hit
PfamiView protein in Pfam
PF00871 Acetate_kinase, 1 hit
PIRSFiPIRSF000722 Acetate_prop_kin, 1 hit
PRINTSiPR00471 ACETATEKNASE
TIGRFAMsiTIGR00016 ackA, 1 hit
PROSITEiView protein in PROSITE
PS01075 ACETATE_KINASE_1, 1 hit
PS01076 ACETATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

B0RIG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVVLVVNSG SSSFKYQLIE MDTETVLASG LVERIGEEVG STRHKAGGDS
60 70 80 90 100
WERELPIADH TAGFQAMLDA FADHGPSLEE GPPVAIGHRV VHGGDVFVEP
110 120 130 140 150
TVVTEKVKAD IDDLSALAPL HNPGALQGIQ AAQTAFPDVA HVAVFDTAFH
160 170 180 190 200
QTLPAEAYTY AIDRELAAAH RIRRYGFHGT SHKYVSEAAA RLLGKPLEET
210 220 230 240 250
RIIVLHLGNG ASAAAVQGGR SIDTSMGLTP LEGLVMGTRS GDIDPAILFH
260 270 280 290 300
LARHTDLGLD DLETLLNRKS GLLGLTGLGD MRDVQRAAAD GDEDAQTALG
310 320 330 340 350
VYRHRIRHYV GAYAAQLGGV DAVVFTAGVG ENNPLVRRRS LAGLEFMGIG
360 370 380 390
IDDDRNELIS SEARFVSPDG SPVAVLVIPT DEELEIARQS LAATGN
Length:396
Mass (Da):42,037
Last modified:April 8, 2008 - v1
Checksum:i089C8DB332A27D12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM849034 Genomic DNA Translation: CAQ00278.1
RefSeqiWP_012297635.1, NZ_MZMN01000003.1

Genome annotation databases

EnsemblBacteriaiCAQ00278; CAQ00278; CMS0154
GeneIDi29470619
KEGGicms:CMS0154

Similar proteinsi

Entry informationi

Entry nameiACKA_CLAMS
AccessioniPrimary (citable) accession number: B0RIG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: July 18, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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