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Protein

Argininosuccinate lyase

Gene

argH

Organism
Clavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1) (Corynebacterium sepedonicum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

UniPathwayi
UPA00068;UER00114

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:CMS1237
OrganismiClavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1) (Corynebacterium sepedonicum)
Taxonomic identifieri31964 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrobacteriaceaeClavibacter
Proteomesi
  • UP000001318 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000738411 – 493Argininosuccinate lyaseAdd BLAST493

Interactioni

Protein-protein interaction databases

STRINGi31964.CMS_1237

Structurei

3D structure databases

ProteinModelPortaliB0RHD6
SMRiB0RHD6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CH7 Bacteria
COG0165 LUCA
KOiK01755
OMAiKKNPDVF
OrthoDBiPOG091H026A

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 1 hit
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

B0RHD6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTESTDPSSR AGEAGALWGG RFAGGPSPEL VALSRSTHFD WQLAPYDIAG
60 70 80 90 100
SRAHARALAA AGYLSDAERQ AMLQALDTLE DRVRSGALVA SEADEDVHGA
110 120 130 140 150
LERGLMDIAG PDLGGKLRAG RSRNDQIATL VRMYLRDHAA VIHAMLVQLV
160 170 180 190 200
DALAAQAEAA GGAIMPGRTH LQHAQPVLLA HHLLAHCWPL VRDLERLADW
210 220 230 240 250
DARADVSPYG SGALAGSTLG LDASAVARDL GFARSSENSI DGTAARDVVA
260 270 280 290 300
EFAFVLAQVG IDLSRLSEEI ILWNTREFGF VTLSDSFSTG SSIMPQKKNP
310 320 330 340 350
DIAELARGKS GRLIGNLSGL LATLKGLPLA YNRDLQEDKE PVFDSVQTLE
360 370 380 390 400
VLLPAFTGMI ATLRFDVDRM AELAPQGFSL ATDVAEWLVK HRVAFRDAHE
410 420 430 440 450
ITGELVKLAE SRGVGLEDLS DDDLRAVSPH LVPEVREVLS IDGSVASRDG
460 470 480 490
VGGTARVRVD EQRAELVRRV AELRARADAA AERRAAASAA ASA
Length:493
Mass (Da):52,529
Last modified:April 8, 2008 - v1
Checksum:i8825D1F88C5D85A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM849034 Genomic DNA Translation: CAQ01353.1
RefSeqiWP_012298631.1, NZ_MZMN01000003.1

Genome annotation databases

EnsemblBacteriaiCAQ01353; CAQ01353; CMS1237
GeneIDi29472179
KEGGicms:CMS1237

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM849034 Genomic DNA Translation: CAQ01353.1
RefSeqiWP_012298631.1, NZ_MZMN01000003.1

3D structure databases

ProteinModelPortaliB0RHD6
SMRiB0RHD6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi31964.CMS_1237

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAQ01353; CAQ01353; CMS1237
GeneIDi29472179
KEGGicms:CMS1237

Phylogenomic databases

eggNOGiENOG4105CH7 Bacteria
COG0165 LUCA
KOiK01755
OMAiKKNPDVF
OrthoDBiPOG091H026A

Enzyme and pathway databases

UniPathwayi
UPA00068;UER00114

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 1 hit
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARLY_CLAMS
AccessioniPrimary (citable) accession number: B0RHD6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: November 7, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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