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UniProtKB - B0R0V8 (B0R0V8_DANRE)
Protein
V-type proton ATPase subunit H
Gene
atp6v1h
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
UniRule annotationGO - Molecular functioni
- proton-transporting ATPase activity, rotational mechanism Source: UniProtKB-UniRule
GO - Biological processi
- bone development Source: ZFIN
- bone mineralization Source: ZFIN
- eye pigmentation Source: CACAO
- pigmentation Source: ZFIN
- positive regulation of neural retina development Source: CACAO
- retina development in camera-type eye Source: ZFIN
Keywordsi
Biological process | Hydrogen ion transportUniRule annotationARBA annotation, Ion transport, Transport |
Enzyme and pathway databases
Reactomei | R-DRE-1222556, ROS and RNS production in phagocytes R-DRE-77387, Insulin receptor recycling R-DRE-917977, Transferrin endocytosis and recycling R-DRE-9639288, Amino acids regulate mTORC1 R-DRE-983712, Ion channel transport |
Names & Taxonomyi
Protein namesi | Recommended name: V-type proton ATPase subunit HUniRule annotation |
Gene namesi | Name:atp6v1hImported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-021219-2, atp6v1h |
Subcellular locationi
Other locations
- vacuolar proton-transporting V-type ATPase, V1 domain Source: UniProtKB-UniRule
Expressioni
Gene expression databases
Bgeei | ENSDARG00000006370, Expressed in brain and 35 other tissues |
Interactioni
Subunit structurei
V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.
UniRule annotationProtein-protein interaction databases
STRINGi | 7955.ENSDARP00000089816 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 345 – 460 | V-ATPase_H_CInterPro annotationAdd BLAST | 116 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2759, Eukaryota |
GeneTreei | ENSGT00390000003289 |
OrthoDBi | 751335at2759 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit 1.25.40.150, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR004908, ATPase_V1-cplx_hsu IPR011987, ATPase_V1-cplx_hsu_C IPR038497, ATPase_V1-cplx_hsu_C_sf |
PANTHERi | PTHR10698, PTHR10698, 1 hit |
Pfami | View protein in Pfam PF11698, V-ATPase_H_C, 1 hit PF03224, V-ATPase_H_N, 1 hit |
PIRSFi | PIRSF032184, ATPase_V1_H, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
B0R0V8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDIRGAVDAA VPTNIIAAKA AEVRANKVNW QSYLQGQMIS GEDCEFIKKF
60 70 80 90 100
EVAGSEDKQA ILTNEGHQCA KTFLNLMAHI SKEQTVQYIL TLIDDTLQEN
110 120 130 140 150
HQRVNIFFDY AKKTKNTAWS YFLPMLNRQD LFTVHMAARI IAKLAAWGRD
160 170 180 190 200
LMEGSDLNYY FNWIKTQLSS QKLHGTGAEP GTGTISPSES SQYVQCVAGC
210 220 230 240 250
LQLMLRVNEY RFAWVEADGV NCITAVLSNK CGFQLQYQMI FCVWLLAFSP
260 270 280 290 300
QLCEQLRRYN VVPALSDILQ ESVKEKVTRI ILAAFRNLLE KSAERETRQE
310 320 330 340 350
YALAMIQCKV LKQLENLDQQ KYDDEDITDD IKFLLERLGE SVQDLSSFDE
360 370 380 390 400
YSSELKSGRL EWSPVHKSEK FWRENAVRLN EKNYELLKIL TRLLEVSDDP
410 420 430 440 450
QVIAVAAHDV GEYVRHYPRG KRVIEQLGGK QLVMNHMHHE DQLVRYNALL
460 470 480
AVQKLMVHNW EYLGKQLQST EQTTPAVAAR S
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ6PC35 | Q6PC35_DANRE | V-type proton ATPase subunit H | atp6v1h | 463 | Annotation score: | ||
F8W3K9 | F8W3K9_DANRE | ATPase H+-transporting V1 subunit H | atp6v1h | 103 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL929096 Genomic DNA No translation available. AL929271 Genomic DNA No translation available. |
RefSeqi | NP_001278637.1, NM_001291708.1 |
Genome annotation databases
Ensembli | ENSDART00000145681.2; ENSDARP00000113453.1; ENSDARG00000006370.9 ENSDART00000189233.1; ENSDARP00000146642.1; ENSDARG00000006370.9 |
GeneIDi | 286779 |
KEGGi | dre:286779 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL929096 Genomic DNA No translation available. AL929271 Genomic DNA No translation available. |
RefSeqi | NP_001278637.1, NM_001291708.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000089816 |
Genome annotation databases
Ensembli | ENSDART00000145681.2; ENSDARP00000113453.1; ENSDARG00000006370.9 ENSDART00000189233.1; ENSDARP00000146642.1; ENSDARG00000006370.9 |
GeneIDi | 286779 |
KEGGi | dre:286779 |
Organism-specific databases
CTDi | 51606 |
ZFINi | ZDB-GENE-021219-2, atp6v1h |
Phylogenomic databases
eggNOGi | KOG2759, Eukaryota |
GeneTreei | ENSGT00390000003289 |
OrthoDBi | 751335at2759 |
Enzyme and pathway databases
Reactomei | R-DRE-1222556, ROS and RNS production in phagocytes R-DRE-77387, Insulin receptor recycling R-DRE-917977, Transferrin endocytosis and recycling R-DRE-9639288, Amino acids regulate mTORC1 R-DRE-983712, Ion channel transport |
Gene expression databases
Bgeei | ENSDARG00000006370, Expressed in brain and 35 other tissues |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit 1.25.40.150, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR004908, ATPase_V1-cplx_hsu IPR011987, ATPase_V1-cplx_hsu_C IPR038497, ATPase_V1-cplx_hsu_C_sf |
PANTHERi | PTHR10698, PTHR10698, 1 hit |
Pfami | View protein in Pfam PF11698, V-ATPase_H_C, 1 hit PF03224, V-ATPase_H_N, 1 hit |
PIRSFi | PIRSF032184, ATPase_V1_H, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B0R0V8_DANRE | |
Accessioni | B0R0V8Primary (citable) accession number: B0R0V8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 8, 2008 |
Last sequence update: | April 8, 2008 | |
Last modified: | May 25, 2022 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |